All Tests

B-type natriuretic peptide (BNP) is a hormone produced by your heart. N-terminal (NT)-pro hormone BNP (NT-proBNP) is a non-active prohormone that is released from the same molecule that produces BNP. Both BNP and NT-proBNP are released in response to changes in pressure inside the heart. These changes can be related to heart failure and other cardiac problems. Levels goes up when heart failure develops or gets worse, and levels goes down when heart failure is stable. In most cases, BNP and NT-proBNP levels are higher in patients with heart failure than people who have normal heart function.

BNP

< 100 pg/mL - HF unlikely

>400 pg/mL - HF likely

100-400 pg/mL - Use clinical judgment

NT-proBNP

< 300 ng/mL - HF unlikely

Age < 50 years, NT-proBNP >450 pg/mL - HF likely

Age 50-75 years, NT-proBNP >900 pg/mL – HF likely

Age >75 years, NT-proBNP >1800 – HF likely

In patients with a prior diagnosis of heart failure, knowledge of optivolemic natriuretic peptide values is important when interpreting elevated levels of these molecules.

Males

< or =45 years: 10-51 pg/mL

46 years: 10-53 pg/mL

47 years: 10-55 pg/mL

48 years: 10-56 pg/mL

49 years: 10-58 pg/mL

50 years: 10-59 pg/mL

51 years: 10-61 pg/mL

52 years: 10-62 pg/mL

53 years: 10-64 pg/mL

54 years: 10-67 pg/mL

55 years: 10-68 pg/mL

56 years: 10-70 pg/mL

57 years: 10-71 pg/mL

58 years: 10-73 pg/mL

59 years: 10-76 pg/mL

60 years: 10-77 pg/mL

61 years: 10-79 pg/mL

62 years: 10-82 pg/mL

63 years: 10-83 pg/m

64 years: 10-85 pg/mL

65 years: 10-88 pg/mL

66 years: 10-89 pg/mL

67 years: 10-92 pg/mL

68 years: 10-95 pg/mL

69 years: 10-97 pg/mL

70 years: 10-100 pg/mL

71 years: 10-103 pg/mL

72 years: 10-104 pg/mL

73 years: 10-107 pg/mL

74 years: 10-110 pg/mL

75 years: 10-113 pg/mL

76 years: 10-116 pg/mL

77 years: 10-119 pg/mL

78 years: 10-122 pg/mL

79 years: 10-125 pg/mL

80 years: 10-128 pg/mL

81 years: 10-131 pg/mL

82 years: 10-135 pg/mL

> or =83 years: 10-138 pg/mL

Females

< or =46 years: 10-140 pg/mL

47 years: 10-141 pg/mL

48 years: 10-144 pg/mL

49 years: 10-146 pg/mL

50 years: 10-149 pg/mL

51 years: 10-150 pg/mL

52 years: 10-152 pg/mL

53 years: 10-155 pg/mL

54 years: 10-157 pg/mL

55 years: 10-160 pg/mL

56 years: 10-162 pg/mL

57 years: 10-166 pg/mL

58 years: 10-168 pg/mL

59 years: 10-171 pg/mL

60 years: 10-173 pg/mL

61 years: 10-177 pg/mL

62 years: 10-179 pg/mL

63 years: 10-183 pg/mL

64 years: 10-185 pg/mL

65 years: 10-189 pg/mL

66 years: 10-193 pg/mL

67 years: 10-196 pg/mL

68 years: 10-199 pg/mL

69 years: 10-202 pg/mL

70 years: 10-206 pg/mL

71 years: 10-210 pg/mL

72 years: 10-214 pg/mL

73 years: 10-218 pg/mL

74 years: 10-222 pg/mL

75 years: 10-227 pg/mL

76 years: 10-230 pg/mL

77 years: 10-235 pg/mL

78 years: 10-239 pg/mL

79 years: 10-244 pg/mL

80 years: 10-248 pg/mL

81 years: 10-253 pg/mL

82 years: 10-258 pg/mL

> or =83 years: 10-263 pg/mL