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Whooping cough (pertussis) is a highly contagious respiratory tract infection. In many people, it's marked by a severe hacking cough followed by a high-pitched intake of breath that sounds like "whoop."Before the vaccine was developed, whooping cough was considered a childhood disease. Now whooping cough primarily affects children too young to have completed the full course of vaccinations and teenagers and adults whose immunity has faded.Deaths associated with whooping cough are rare but most commonly occur in infants. That's why it's so important for pregnant women — and other people who will have close contact with an infant — to be vaccinated against whooping cough.

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ON THIS PAGE: You will find out more about body changes and other things that can signal a problem that may need medical care. To see other pages, use the menu.Children with a Wilms tumor may experience the following symptoms or signs. Sometimes, children with a Wilms tumor do not have any of these changes. Or, the cause of a symptom may be another medical condition that is not cancer.Usually, a Wilms tumor is found before it spreads to other parts of the body. A parent or relative may notice a large lump or feel a hard mass in the child’s belly or notice that the belly is much larger than usual. In some cases, a rapid change to a larger diaper size alerts parents to the presence of a tumor. A few children have abdominal pain. However, most of the time the tumor grows without causing pain, and the child feels and appears healthy.


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A wrist fracture is a medical term for a broken wrist. The wrist is made up of eight small bones which connect with the two long forearm bones called the radius and ulna. Although a broken wrist can happen in any of these 10 bones, by far the most common bone to break is the radius. This is called a distal radius fracture by hand surgeons (Figure 1).Some wrist fractures are stable. “Non-displaced” breaks, in which the bones do not move out of place initially, can be stable. Some “displaced” breaks (which need to be put back into the right place, called “reduction” or “setting”) also can be stable enough to treat in a cast or splint. Other fractures are unstable. In unstable fractures, even if the bones are put back into position and a cast is placed, the bone pieces tend to move or shift into a bad position before they solidly heal. This can make the wrist appear crooked.Some fractures are more severe than others. Fractures that break apart the smooth joint surface or fractures that shatter into many pieces (comminuted fractures) may make the bone unstable. These severe types of fractures often require surgery to restore and hold their alignment. An open fracture occurs when a fragment of bone breaks and is forced out through the skin. This can cause an increased risk of infection in the bone.

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X-linked agammaglobulinemia (XLA) is a condition that affects the immune system and occurs almost exclusively in males. People with XLA have very few B cells, which are specialized white blood cells that help protect the body against infection. B cells can mature into the cells that produce special proteins called antibodies or immunoglobulins. Antibodies attach to specific foreign particles and germs, marking them for destruction. Individuals with XLA are more susceptible to infections because their body makes very few antibodies.Children with XLA are usually healthy for the first 1 or 2 months of life because they are protected by antibodies acquired before birth from their mother. After this time, the maternal antibodies are cleared from the body, and the affected child begins to develop recurrent infections. In children with XLA, infections generally take longer to get better and then they come back again, even with antibiotic medications. The most common bacterial infections that occur in people with XLA are lung infections (pneumonia and bronchitis), ear infections (otitis), pink eye (conjunctivitis), and sinus infections (sinusitis). Infections that cause chronic diarrhea are also common. Recurrent infections can lead to organ damage. People with XLA can develop severe, life-threatening bacterial infections; however, affected individuals are not particularly vulnerable to infections caused by viruses. With treatment to replace antibodies, infections can usually be prevented, improving the quality of life for people with XLA.


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Plague is a serious bacterial infection that's transmitted by fleas. Known as the Black Death during medieval times, today plague occurs in fewer than 5,000 people a year worldwide. It can be deadly if not treated promptly with antibiotics.The organism that causes plague, Yersinia pestis, lives in small rodents found most commonly in rural and semirural areas of Africa, Asia and the United States. The organism is transmitted to humans who are bitten by fleas that have fed on infected rodents or by humans handling infected animals.The most common form of plague results in swollen and tender lymph nodes — called buboes — in the groin, armpits or neck. The rarest and deadliest form of plague affects the lungs, and it can be spread from person to person.


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Zika (Zee-ka) virus disease is a mosquito-borne viral infection that primarily occurs in tropical and subtropical areas of the world. Most people infected with Zika virus have no signs and symptoms, while others report mild fever, rash and muscle pain. Other signs and symptoms may include headache, red eyes (conjunctivitis) and a general feeling of discomfort.


Zika virus infections during pregnancy have been linked to miscarriage and can cause microcephaly, a potentially fatal congenital brain condition. Zika virus also may cause other neurological disorders such as Guillain-Barre syndrome.


Researchers are working on a Zika virus vaccine. For now the best prevention is to prevent mosquito bites and reduce mosquito habitats.

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A double uterus is a rare congenital abnormality. In a female fetus, the uterus starts out as two small tubes. As the fetus develops, the tubes normally join to create one larger, hollow organ — the uterus.


Sometimes, however, the tubes don't join completely. Instead, each one develops into a separate structure. A double uterus may have one opening (cervix) into one vagina, or each uterine cavity may have a cervix. In many cases, a thin wall of tissue runs down the length of the vagina, dividing it into two separate openings.


Women who have a double uterus often have successful pregnancies. But the condition can increase the risk of miscarriage or premature birth.

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A drug allergy is the abnormal reaction of your immune system to a medication. Any medication — over-the-counter, prescription or herbal — is capable of inducing a drug allergy. However, a drug allergy is more likely with certain medications.


The most common signs and symptoms of drug allergy are hives, rash or fever. A drug allergy may cause serious reactions, including a life-threatening condition that affects multiple body systems (anaphylaxis).


A drug allergy is not the same as a drug side effect, a known possible reaction listed on a drug label. A drug allergy is also different from drug toxicity caused by an overdose of medication.

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Dumping syndrome is a condition that can develop after surgery to remove all or part of your stomach or after surgery to bypass your stomach to help you lose weight. Also called rapid gastric emptying, dumping syndrome occurs when food, especially sugar, moves from your stomach into your small bowel too quickly.


Most people with dumping syndrome develop signs and symptoms, such as abdominal cramps and diarrhea, 10 to 30 minutes after eating. Other people have symptoms one to three hours after eating, and still others have both early and late symptoms.


Generally, you can help prevent dumping syndrome by changing your diet after surgery. Changes might include eating smaller meals and limiting high-sugar foods. In more-serious cases of dumping syndrome, you may need medications or surgery.

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Dust mite allergy is an allergic reaction to tiny bugs that commonly live in house dust. Signs of dust mite allergy include those common to hay fever, such as sneezing and runny nose. Many people with dust mite allergy also experience signs of asthma, such as wheezing and difficulty breathing.


Dust mites, close relatives of ticks and spiders, are too small to see without a microscope. Dust mites eat skin cells shed by people, and they thrive in warm, humid environments. In most homes, such items as bedding, upholstered furniture and carpeting provide an ideal environment for dust mites.


By taking steps to reduce the number of dust mites in your home, you may get control of dust mite allergy. Medications or other treatments are sometimes necessary to relieve symptoms and manage asthma.

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 Central nervous system (CNS) embryonal tumors form in embryonic cells that remain in the brain after birth. CNS embryonal tumors tend to spread through the cerebrospinal fluid (CSF) to other parts of the brain and spinal cord.

The tumors may be malignant (cancer) or benign (not cancer). Most CNS embryonal tumors in children are malignant. Malignant brain tumors are likely to grow quickly and spread into other parts of the brain. When a tumor grows into or presses on an area of the brain, it may stop that part of the brain from working the way it should. Benign brain tumors grow and press on nearby areas of the brain. They rarely spread to other parts of the brain. Both benign and malignant brain tumors can cause signs or symptoms and need treatment.

Although cancer is rare in children, brain tumors are the third most common type of childhood cancer, after leukemia and lymphoma. This summary is about the treatment of primary brain tumors (tumors that begin in the brain). The treatment of metastatic brain tumors, which begin in other parts of the body and spread to the brain, is not discussed in this summary. For information about the different types of brain and spinal cord tumors, see the PDQ summary on Childhood Brain and Spinal Cord Tumors Treatment Overview.

Brain tumors occur in both children and adults. Treatment for adults may be different from treatment for children. See the PDQ summary on Adult Central Nervous System Tumors Treatment for more information on the treatment of adults.

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Epidermolysis bullosa (ep-ih-dur-MOL-uh-sis buhl-LOE-sah) is a group of rare diseases that cause fragile, blistering skin. The blisters may appear in response to minor injury, even from heat, rubbing, scratching or adhesive tape. In severe cases, the blisters may occur inside the body, such as the lining of the mouth or the stomach.


Most types of epidermolysis bullosa are inherited. The condition usually shows up in infancy or early childhood. Some people don't develop signs and symptoms until adolescence or early adulthood.


Epidermolysis bullosa has no cure, though mild forms may improve with age. Treatment focuses on caring for blisters and preventing new ones.

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Congestive Heart Failure (Heart Failure) – Pipeline Review, H2 2017, provides an overview of the Congestive Heart Failure (Heart Failure) (Cardiovascular) pipeline landscape.

Heart failure is also known as congestive heart failure (CHF). CHF is a condition in which the heart is no longer able to pump out enough oxygen-rich blood. Symptoms include cough, fatigue, weakness, faintness, loss of appetite, swollen (enlarged) liver or abdomen, swollen feet and ankles and weight gain. The predisposing factors include high blood pressure, diabetes, sleep apnea, alcohol use and irregular heartbeats. Treatment includes surgery, vasodilator, beta blockers and diuretics.

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Esthesioneuroblastoma (es-THEE-zee-o-NOO-row-blas-TOE-muh) is a rare type of cancer that begins in the upper portion of the nasal cavity.


The area where esthesioneuroblastoma begins is separated from the brain by a bone that contains tiny holes that allow the nerves that control smell (olfactory nerves) to pass through. Esthesioneuroblastoma is also called olfactory neuroblastoma.


Esthesioneuroblastoma, which can occur at any age in adults, generally begins as a tumor in the nasal cavity and may grow or extend into the sinus, eyes and brain. People with esthesioneuroblastoma can lose their sense of smell, have frequent nosebleeds and experience difficulty breathing through their nostrils as the tumor grows.


Esthesioneuroblastoma can also spread to the lymph nodes in the neck and the parotid glands. In advanced cases, esthesioneuroblastoma can spread to other parts of the brain and other parts of the body, such as the lungs, liver and bones.


Esthesioneuroblastoma treatment usually includes surgery. Often, radiation and chemotherapy are recommended, as well.

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Factitious disorder is a serious mental disorder in which someone deceives others by appearing sick, by purposely getting sick or by self-injury. Factitious disorder also can happen when family members or caregivers falsely present others, such as children, as being ill, injured or impaired.


Factitious disorder symptoms can range from mild (slight exaggeration of symptoms) to severe (previously called Munchausen syndrome). The person may make up symptoms or even tamper with medical tests to convince others that treatment, such as high-risk surgery, is needed.


Factitious disorder is not the same as inventing medical problems for practical benefit, such as getting out of work or winning a lawsuit. Although people with factitious disorder know they are causing their symptoms or illnesses, they may not understand the reasons for their behaviors or recognize themselves as having a problem.


Factitious disorder is challenging to identify and hard to treat. However, medical and psychiatric help are critical for preventing serious injury and even death caused by the self-harm typical of this disorder.

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A febrile seizure is a convulsion in a child that may be caused by a spike in body temperature, often from an infection. Your child's having a febrile seizure can be alarming, and the few minutes it lasts can seem like an eternity.


Febrile seizures represent a unique response of a child's brain to fever, usually the first day of a fever. Fortunately, they're usually harmless and typically don't indicate an ongoing problem. You can help by keeping your child safe during a febrile seizure and by comforting him or her afterward.

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A sexual problem, or sexual dysfunction, refers to a problem during any phase of the sexual response cycle that prevents the individual or couple from experiencing satisfaction from the sexual activity. The sexual response cycle has four phases: excitement, plateau, orgasm, and resolution.


While research suggests that sexual dysfunction is common (43% of women and 31% of men report some degree of difficulty), it is a topic that many people are hesitant or embarrassed to discuss. Fortunately, most cases of sexual dysfunction are treatable, so it is important to share your concerns with your partner and doctor.

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Fibromuscular dysplasia is a condition that causes narrowing (stenosis) and enlargement (aneurysm) of the medium-sized arteries in your body. Reduced blood flow from narrowed arteries to the organs can affect the function of the organs.


Fibromuscular dysplasia appears most commonly in the arteries leading to the kidneys. Fibromuscular dysplasia can also affect the arteries leading to your brain, heart, abdomen, arms and legs.


Fibromuscular dysplasia can cause a number of complications, such as high blood pressure or tears of the artery (arterial dissection), if left untreated. Arterial dissection, or spontaneous coronary artery dissection (SCAD), can limit blood flow to the organ supplied by the injured artery.

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Fibrous dysplasia is an uncommon bone disorder in which scar-like (fibrous) tissue develops in place of normal bone. This irregular tissue can weaken the affected bone and cause it to deform or fracture.


In most cases, fibrous dysplasia occurs at a single site in one bone, but can occur at multiple sites in multiple bones. Single bone involvement usually occurs in adolescents and young adults. People who have more than one affected bone typically develop symptoms before the age of 10.


Although fibrous dysplasia is a genetic disorder, it's caused by a gene mutation that's not passed from parent to child. There's no cure for the disorder. Treatment, which may include surgery, focuses on relieving pain and repairing or stabilizing bones.

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Folliculitis is an inflammatory condition affecting hair follicles. It appears as a small red tender bump occasionally surmounted with dot of pus surrounding a hair. Older lesions that have lost the pus appear as red bumps surrounding the opening of the follicle absent the hair. One to hundreds of follicles can be affected anywhere that hair is present. Actually, acne vulgaris, the facial rash that teenagers develop, is a type of folliculitis.


Depending on the cause and severity of folliculitis, it may require no treatment and resolve spontaneously, or it may require treatment with powerful antibiotics or other drugs.

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Frozen shoulder is the common name for adhesive capsulitis, which is a shoulder condition that limits your range of motion. When the tissues in your shoulder joint become thicker and tighter, scar tissue develops over time. As a result, your shoulder joint doesn’t have enough space to rotate properly. Common symptoms include swelling, pain, and stiffness. You’re more likely to have the condition if you’re between the ages of 40 and 60.

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Gaucher (go-SHAY) disease is the result of a buildup of certain fatty substances in certain organs, particularly your spleen and liver. This causes these organs to enlarge and can affect their function.


The fatty substances also can build up in bone tissue, weakening the bone and increasing the risk of fractures. If the bone marrow is affected, it can interfere with your blood's ability to clot.


An enzyme that breaks down these fatty substances doesn't work properly in people with Gaucher disease. Treatment often includes enzyme replacement therapy.


An inherited disorder, Gaucher disease is most common in Jewish people of Eastern and Central European descent (Ashkenazi). Symptoms can appear at any age.

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Geographic tongue is the name of a condition that gets its name from its map-like appearance on the upper surface and sides of the tongue. It may occur in other areas of your mouth, as well.


You'll be relieved to know that geographic tongue is a harmless, benign condition that isn't linked to any infection or cancer. Two other names for geographic tongue are benign migratory glossitis and erythema migrans.


Affecting about 1% to 3% of people, geographic tongue can show up at any age. However, it tends to affect middle-aged or older adults more often. It appears to be more common in women than in men.

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Germ cell tumors are growths that form from reproductive cells. Tumors may be cancerous or noncancerous. Most germ cell tumors that are cancerous occur as cancer of the testicles (testicular cancer) or cancer of the ovaries (ovarian cancer).


Some germ cell tumors occur in other areas of the body, such as the abdomen, brain and chest, though it's not clear why. Germ cell tumors that occur in places other than the testicles and ovaries (extragonadal germ cell tumors) are very rare.


Germ cell tumors tend to respond to treatment and many can be cured, even when diagnosed at a late stage.

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Glomerulonephritis (gloe-mer-u-low-nuh-FRY-tis) is inflammation of the tiny filters in your kidneys (glomeruli). Glomeruli remove excess fluid, electrolytes and waste from your bloodstream and pass them into your urine. Glomerulonephritis can come on suddenly (acute) or gradually (chronic).


Glomerulonephritis occurs on its own or as part of another disease, such as lupus or diabetes. Severe or prolonged inflammation associated with glomerulonephritis can damage your kidneys. Treatment depends on the type of glomerulonephritis you have.

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A grand mal seizure causes a loss of consciousness and violent muscle contractions. It's the type of seizure most people picture when they think about seizures.


A grand mal seizure — also known as a generalized tonic-clonic seizure — is caused by abnormal electrical activity throughout the brain. Usually, a grand mal seizure is caused by epilepsy. But sometimes, this type of seizure can be triggered by other health problems, such as extremely low blood sugar, a high fever or a stroke.


Many people who have a grand mal seizure never have another one and don't need treatment. But someone who has recurrent seizures may need treatment with daily anti-seizure medications to control and prevent future grand mal seizures.


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Granuloma annulare (gran-u-LOW-muh an-u-LAR-e) is a skin condition that most commonly consists of raised, reddish or skin-colored bumps (lesions) that form ring patterns — usually on your hands and feet.


No one knows exactly what causes granuloma annulare. But it may be triggered by minor skin injuries and certain medications. Some types of granuloma annulare affect adults, and others typically affect children.


In most cases, granuloma annulare isn't itchy or painful, so no treatment is necessary. The lesions usually disappear on their own within two years. If you're bothered by how your skin looks, your doctor can prescribe medications that will speed the disappearance of the lesions.

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Greenstick fractures occur when the force applied to a bone results in bending of the bone such that the structural integrity of the convex surface is overcome. The fact that the integrity of the cortex has been overcome results in fracture of the convex surface. However, the bending force applied does not break the bone completely and the concave surface of the bent bone remains intact.


This can occur following an angulated longitudinal force applied down the bone (e.g. an indirect trauma following a fall on an outstretched arm), or after a force applied perpendicular to the bone (e.g. a direct blow).


This fracture is very different, and much less common, than the torus fracture that results in buckling of the cortex on the concave side of the bend and an intact concave surface.

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The hamstrings are the tendons that attach the large muscles at the back of the thigh to bone. The hamstring muscles are the large muscles that pull on these tendons. It has become common in layman's terminology (and by some medical personnel) to refer to the long muscles at the back of the thigh as the "hamstrings" or "hamstring muscles." Academic anatomists refer to them as the posterior thigh muscles, and more specifically as the semimembranosus, the semitendinosus, and the biceps femoris muscles. These muscles span the thigh, crossing both the hip and the knee. They originate or begin at just below the buttocks, arising from the bone on which we sit (the ischium). They connect by means of their tendons onto the upper parts of the lower leg bones (the tibia and the fibula).


The origin of the word hamstring comes from the old English hamm, meaning thigh. String refers to the characteristic appearance and feel of the tendons just above the back of the knee. Although the tendons are sometimes involved in injuries, this article will refer to the "hamstrings" as the large muscle group at the back of the thigh because the most frequent problems involve this muscle group.

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Heat exhaustion is a condition whose symptoms may include heavy sweating and a rapid pulse, a result of your body overheating. It's one of three heat-related syndromes, with heat cramps being the mildest and heatstroke being the most severe.


Causes of heat exhaustion include exposure to high temperatures, particularly when combined with high humidity, and strenuous physical activity. Without prompt treatment, heat exhaustion can lead to heatstroke, a life-threatening condition. Fortunately, heat exhaustion is preventable.

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A cough is a common reflex action that clears the throat of mucus or foreign irritants. Coughing to clear the throat is typically an infrequent action, although a number of conditions can cause more frequent bouts of coughing.


In general, a cough that lasts for less than three weeks is an acute cough.


A cough that lasts between 3 and 8 weeks, improving by the end of that period, is a subacute cough.


A persistent cough that lasts more than eight weeks is a chronic cough.


Most cough episodes will clear up, or at least significantly improve, within two weeks. If you cough up blood or have a “barking” cough, talk to your doctor. Any cough that hasn’t improved after a few weeks may be serious, and you should see a doctor.

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Hidradenitis suppurativa (hi-drad-uh-NIE-tis sup-yoo-ruh-TIE-vuh) is rare, long-term skin condition that features small, painful lumps under the skin. They typically develop where the skin rubs together, such as the armpits, the groin, between the buttocks and under the breasts. The lumps may break open and smell or cause tunnels under the skin.


Hidradenitis suppurativa tends to start after puberty. It can persist for many years and worsen over time, with serious effects on your daily life and emotional well-being. Early diagnosis and treatment can help manage the symptoms, keep new lumps from forming and prevent complications, such as scar

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A hip fracture is a serious injury, with complications that can be life-threatening. The risk of hip fracture rises with age.


Older people are at a higher risk of hip fracture because bones tend to weaken with age (osteoporosis). Multiple medications, poor vision and balance problems also make older people more likely to trip and fall — one of the most common causes of hip fracture.


A hip fracture almost always requires surgical repair or replacement, followed by months of physical therapy. Taking steps to maintain bone density and avoid falls can help prevent hip fracture.

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Hirsutism (HUR-soot-iz-um) is a condition of unwanted, male-pattern hair growth in women. Hirsutism results in excessive amounts of dark, course hair on body areas where men typically grow hair — face, chest and back.


The amount of body hair you have is largely determined by your genetic makeup. There's a wide range of normal hair distribution, thickness and color due to differences in heredity. However, hirsutism is a medical condition that can arise from excess male hormones called androgens, primarily testosterone. It can also be due to a family trait.

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Hunter syndrome is a very rare, inherited genetic disorder caused by a missing or malfunctioning enzyme. Because the body doesn't have enough of the enzyme to break down certain complex molecules, the molecules build up in harmful amounts.


In Hunter syndrome, the buildup of massive amounts of these harmful substances eventually causes permanent, progressive damage affecting appearance, mental development, organ function and physical abilities.


Hunter syndrome appears in children as young as 18 months. It mainly occurs in boys, although very rarely it has been observed in girls.


There's no cure for Hunter syndrome. Treatment of Hunter syndrome involves management of symptoms and complications.

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Huntington's disease (HD) is a neurological condition. It is an inherited disease that happens due to faulty genes. Toxic proteins collect in the brain and cause damage, leading to neurological symptoms.


As parts of the brain deteriorate, this affects movement, behavior, and cognition. It becomes harder to walk, think, reason, swallow, and talk. Eventually, the person will need full-time care. The complications are usually fatal.


There is currently no cure, but treatment can help with symptoms.

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The term hydrocephalus is derived from the Greek words "hydro" meaning water and "cephalus" meaning head. As the name implies, it is a condition in which the primary characteristic is excessive accumulation of fluid in the brain. Although hydrocephalus was once known as "water on the brain," the "water" is actually cerebrospinal fluid (CSF)--a clear fluid that surrounds the brain and spinal cord. The excessive accumulation of CSF results in an abnormal widening of spaces in the brain called ventricles. This widening creates potentially harmful pressure on the tissues of the brain.


The ventricular system is made up of four ventricles connected by narrow passages.. Normally, CSF flows through the ventricles, exits into cisterns (closed spaces that serve as reservoirs) at the base of the brain, bathes the surfaces of the brain and spinal cord, and then reabsorbs into the bloodstream.


CSF has three important life-sustaining functions: 1) to keep the brain tissue buoyant, acting as a cushion or "shock absorber"; 2) to act as the vehicle for delivering nutrients to the brain and removing waste; and 3) to flow between the cranium and spine and compensate for changes in intracranial blood volume (the amount of blood within the brain).


The balance between production and absorption of CSF is critically important. Because CSF is made continuously, medical conditions that block its normal flow or absorption will result in an over-accumulation of CSF. The resulting pressure of the fluid against brain tissue is what causes hydrocephalus.

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Hypopituitarism is a rare disorder in which your pituitary gland either fails to produce one or more of its hormones or doesn't produce enough of them.


The pituitary gland is a small bean-shaped gland situated at the base of your brain, behind your nose and between your ears. Despite its size, this gland secretes hormones that influence nearly every part of your body.


In hypopituitarism, you have a short supply of one or more of these pituitary hormones. This deficiency can affect any number of your body's routine functions, such as growth, blood pressure and reproduction.


You'll likely need medications for the rest of your life to treat hypopituitarism, but your symptoms can be controlled.


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Ichthyosis (ick-thee-OH-sis) is a group of skin diseases that causes extremely dry, thick, and scaly skin. The skin often looks like it has fish scales.


There are more than 20 different types of ichthyosis. The most common type is ichthyosis vulgaris (vul-GAR-ris). About 95% of people who develop ichthyosis get this type.


The other types are rare and include harlequin ichthyosis, lamellar type, and x-linked ichthyosis.

Of all the types, ichthyosis vulgaris is the mildest. It often begins in childhood.

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Jaundice is particularly common in premature babies - boys more often than girls. It usually appears within the baby's first week of life.


In an otherwise healthy baby born at full term, infant jaundice is rarely a cause for alarm; it tends to go away on its own. However, if treatment is necessary, infants tend to respond to non-invasive therapy.


In rare cases, untreated infant jaundice may lead to brain damage and even death.

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Infant reflux occurs when food backs up (refluxes) from a baby's stomach, causing the baby to spit up. Sometimes called gastroesophageal reflux (GER), the condition is rarely serious and becomes less common as a baby gets older. It's unusual for infant reflux to continue after age 18 months.


Reflux occurs in healthy infants multiple times a day. As long as your baby is healthy, content and growing well, the reflux is not a cause for concern.


Rarely, infant reflux can be a sign of a medical problem, such as an allergy, a blockage in the digestive system or gastroesophageal reflux disease (GERD).

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Infectious diseases kill more people worldwide than any other single cause. Infectious diseases are caused by germs. Germs are tiny living things that are found everywhere - in air, soil and water. You can get infected by touching, eating, drinking or breathing something that contains a germ. Germs can also spread through animal and insect bites, kissing and sexual contact. Vaccines, proper hand washing and medicines can help prevent infections.

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You can also catch flu by touching an infected person, for instance, shaking hands. Adults are contagious 1-2 days before getting symptoms and up to 7 days after becoming ill. This means that you can spread the influenza virus before you even know you are infected.


In this article, we explain the symptoms of flu, how it is treated, how it differs from a cold, and the best ways to prevent flu occurring.

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An inguinal hernia occurs in the abdomen near the groin area. They develop when fatty or intestinal tissues push through a weakness in the abdominal wall near the right or left inguinal canal. Each inguinal canal resides at the base of the abdomen.


Both men and woman have inguinal canals. In men, the testes usually descend through their canal by around a few weeks before birth. In women, each canal is the location of passage for the round ligament of the uterus. If you have a hernia in or near this passageway, it results in a protruding bulge. It may be painful during movement.


Many people don’t seek treatment for this type of hernia because it may be small or not cause any symptoms. Prompt medical treatment can help prevent further protrusion and discomfort.

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Interstitial (in-tur-STISH-ul) lung disease describes a large group of disorders, most of which cause progressive scarring of lung tissue. The scarring associated with interstitial lung disease eventually affects your ability to breathe and get enough oxygen into your bloodstream.


Interstitial lung disease can be caused by long-term exposure to hazardous materials, such as asbestos. Some types of autoimmune diseases, such as rheumatoid arthritis, also can cause interstitial lung disease. In some cases, however, the causes remain unknown.


Once lung scarring occurs, it's generally irreversible. Medications may slow the damage of interstitial lung disease, but many people never regain full use of their lungs. Lung transplant is an option for some people who have interstitial lung disease.

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Digested food particles must travel through 25 feet or more of intestines as part of normal digestion. These digested wastes are constantly in motion. However, intestinal obstruction can put a stop to this. An intestinal obstruction occurs when your small or large intestine is blocked. The blockage can be partial or total, and it prevents passage of fluids and digested food.


If intestinal obstruction happens, food, fluids, gastric acids, and gas build up behind the site of the blockage. If enough pressure builds up, your intestine can rupture, leaking harmful intestinal contents and bacteria into your abdominal cavity. This is a life-threatening complication.


There are many potential causes of intestinal obstruction. Often, this condition can’t be prevented. Early diagnosis and treatment are crucial. An untreated intestinal obstruction can be fatal.

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Intussusception (in-tuh-suh-SEP-shun) is the most common abdominal emergency affecting children under 2 years old. It happens when one portion of the bowel slides into the next, much like the pieces of a telescope.


When this "telescoping" happens, the flow of fluids and food through the bowel can become blocked, the intestine can swell and bleed, and the blood supply to the affected part of the intestine can get cut off. Eventually, this can cause part of the bowel to die.


Intussusception happens in 1 to 4 out of every 1,000 infants and is most common in babies 5 to 9 months old, though older children also can have it. Boys get intussusception more often than girls.

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Invasive lobular carcinoma is a type of breast cancer that begins in the milk-producing glands (lobules) of the breast.


Invasive cancer means the cancer cells have broken out of the lobule where they began and have the potential to spread to the lymph nodes and other areas of the body.


Invasive lobular carcinoma makes up a small portion of all breast cancers. The most common type of breast cancer begins in the breast ducts (invasive ductal carcinoma).


Invasive lobular carcinoma typically doesn't form a lump, which is common in breast cancer. Instead, there is a change in the breast that feels like a thickening or fullness in one part of the breast and is different from the surrounding breast tissue.

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Juvenile-onset fibromyalgia (JFM) is a poorly understood chronic pain condition most commonly affecting adolescent girls. The condition is characterized by widespread musculoskeletal pain and other associated symptoms, including fatigue, nonrestorative sleep, headaches, irritable bowel symptoms, dysautonomia and mood disorders such as anxiety and/or depression. In the past few years, there has been a greater focus on understanding JFM in adolescents. Research studies have provided insight into the clinical characteristics of this condition and its effect on both short-term and long-term psychosocial and physical functioning. The importance of early and effective intervention is being recognized, as research has shown that symptoms of JFM tend to persist and do not resolve over time as was previously believed. Efforts to improve treatments for JFM are underway, and new evidence strongly points to the potential benefits of cognitive–behavioural therapy on improving mood and daily functioning. Research into pharmacotherapy and other nonpharmacological options is in progress. Advancements in the understanding of adult fibromyalgia have paved the way for future studies on diagnosis, assessment and management of JFM. This Review focuses on our current knowledge of the condition, provides an update of the latest research advances, and highlights areas for further study.

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We see through the cornea, which is the clear outer lens or "windshield" of the eye. Normally, the cornea has a dome shape, like a ball. Sometimes, however, the structure of the cornea is just not strong enough to hold this round shape and the cornea bulges outward like a cone. This condition is called keratoconus.

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A bursa is a closed, fluid-filled sac that functions as a gliding surface to reduce friction between tissues of the body. Bursae is plural for bursa. The major bursae are located adjacent to the tendons near the large joints, such as the shoulders, elbows, hips, and knees. When a bursa becomes inflamed, the condition is known as bursitis. Most commonly, bursitis is caused by local soft-tissue trauma or strain injury, and there is no infection (aseptic bursitis). On rare occasions, particularly when the immune system is suppressed, the bursa can become infected with bacteria. This condition is called septic bursitis.

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Lichen nitidus is an unusual/ rare non-infectious skin condition most commonly seen in children. It occurs in the form of hundreds and hundreds of tiny grids of bumps over the skin. They are often found in tight groups that appear like a big patch.


The arms and the folds of the skin are most commonly affected, but they can occur anywhere in the body. In fairer skinned people, these bumps are slightly reddish in color, whereas in darker skinned people, the bumps may vary between lighter or darker in color than the normal skin.

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Lichen sclerosus (LIE-kun skluh-ROW-sus) is an uncommon condition that creates patchy, white skin that's thinner than normal. Lichen sclerosus can affect skin anywhere on your body. But it most often involves skin of the vulva, foreskin of the penis or skin around the anus.


Anyone can get lichen sclerosus but postmenopausal women have a high risk.


Sometimes lichen sclerosus improves on its own, and you won't need any treatment. If you do need treatment, your doctor can suggest options to return a more normal appearance to your skin and decrease the tendency for scarring.

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Each strand of hair is made up of the medulla, cortex, and cuticle.[4] The innermost region, the medulla, is not always present and is an open, unstructured region.[5] The highly structural and organized cortex, or middle layer of the hair, is the primary source of mechanical strength and water uptake. The cortex contains melanin, which colors the fiber based on the number, distribution and types of melanin granules. The shape of the follicle determines the shape of the cortex, and the shape of the fiber is related to how straight or curly the hair is. People with straight hair have round hair fibers. Oval and other shaped fibers are generally more wavy or curly. The cuticle is the outer covering. Its complex structure slides as the hair swells and is covered with a single molecular layer of lipid that makes the hair repel water.[4] The diameter of human hair varies from 0.017 to 0.18 millimeters (0.00067 to 0.00709 in).[6] There are two million small, tubular glands and sweat glands that produce watery fluids that cool the body by evaporation. The glands at the opening of the hair produce a fatty secretion that lubricates the hair.[7]


Hair growth begins inside the hair follicle. The only "living" portion of the hair is found in the follicle. The hair that is visible is the hair shaft, which exhibits no biochemical activity and is considered "dead". The base of a hair's root (the "bulb") contains the cells that produce the hair shaft.[8] Other structures of the hair follicle include the oil producing sebaceous gland which lubricates the hair and the arrector pili muscles, which are responsible for causing hairs to stand up. In humans with little body hair, the effect results in goose bumps.

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Answer: Low sperm count implies that the fluids (semen) you ejaculate in the course of an orgasm consist of lesser sperm when compared with normal.


A low sperm count can be referred to as oligospermia. A total lack of sperm is known as Azoospermia. Your own sperm count is regarded as less than normal when you have less than fifteen million sperm per millilitre of semen.


Having a low sperm count reduces the chances that one of your own sperm will certainly fertilize the partner’s egg, leading to pregnancy. Nevertheless, numerous males that have a low sperm count will still be in a position to father a baby.

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Lupus nephritis is inflammation of the kidney that is caused by systemic lupus erythematous (SLE). Also called lupus, SLE is an autoimmune disease. With lupus, the body's immune system targets its own body tissues. Lupus nephritis happens when lupus involves the kidneys.


Up to 60% of lupus patients will develop lupus nephritis. When the kidneys are inflamed, they can't function normally and can leak protein. If not controlled, lupus nephritis can lead to kidney failure.

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Mammary duct ectasia (ek-TAY-zhuh) occurs when a milk duct beneath your nipple widens, the duct walls thicken and the duct fills with fluid. The milk duct may become blocked or clogged with a thick, sticky substance. The condition often causes no symptoms, but some women may have nipple discharge, breast tenderness or inflammation of the clogged duct (periductal mastitis).

Mammary duct ectasia most often occurs in women of perimenopausal age — around 45 to 55 years — but it can happen after menopause, too. The condition sometimes improves without treatment. If symptoms persist, you may need antibiotics or possibly surgery to remove the affected milk duct.Though it's normal to worry about any changes in your breasts, mammary duct ectasia and periductal mastisis aren't risk factors for breast cancer


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MEdulloblastoma is a cancerous tumor—also called cerebellar primitive neuroectodermal tumor (PNET)—that starts in the region of the brain at the base of the skull, called the posterior fossa. These tumors tend to spread to other parts of the brain and to the spinal cord


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Membranous nephropathy (MEM-bruh-nus nuh-FROP-uh-thee) occurs when the small blood vessels in the kidney (glomeruli), which filter wastes from the blood, become damaged and thickened. As a result, proteins leak from the damaged blood vessels into the urine (proteinuria). For many, loss of these proteins eventually causes signs and symptoms known as nephrotic syndrome.In mild cases, membranous nephropathy may get better on its own, without any treatment. As protein leakage increases, so does the risk of long-term kidney damage. In many, the disease ultimately leads to kidney failure. There's no absolute cure for membranous nephropathy, but successful treatment can lead to remission of proteinuria and a good long-term outlook.


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Migraine with aura (also called classic migraine) is a headache that strikes after or along with sensory disturbances called aura. These disturbances can include flashes of light, blind spots and other vision changes or tingling in your hand or face.Treatments for migraine with aura and migraine without aura (also called common migraine) are usually the same. You can try to prevent migraine with aura with the same medications and self-care measures used to prevent migraine.

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Dandruff is a skin condition that affects mainly the scalp. Symptoms include flaking and sometimes mild itchiness.It can result in social or self-esteem problems. A more severe form of the condition, which includes inflammation of the skin, is known as seborrheic dermatitis.


The cause is unclear but believed to involve a number of genetic and environmental factors. The condition may worsen in the winter.It is not due to poor hygiene. The underlying mechanism involves the over growth of skin cells.Diagnosis is based on symptoms.


There is no known cure.The typical treatment is with antifungal cream such as ketoconazole. Dandruff affects about half of adults. Onset is usually at puberty. Males are more often affected than females.Rates decrease after the age of 50.


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Molluscum contagiosum is an infection caused by a poxvirus (molluscum contagiosum virus). The result of the infection is usually a benign, mild skin disease characterized by lesions (growths) that may appear anywhere on the body. Within 6-12 months, Molluscum contagiosum typically resolves without scarring but may take as long as 4 years.The lesions, known as Mollusca, are small, raised, and usually white, pink, or flesh-colored with a dimple or pit in the center. They often have a pearly appearance. They’re usually smooth and firm. In most people, the lesions range from about the size of a pinhead to as large as a pencil eraser (2 to 5 millimeters in diameter). They may become itchy, sore, red, and/or swollen.Mollusca may occur anywhere on the body including the face, neck, arms, legs, abdomen, and genital area, alone or in groups. The lesions are rarely found on the palms of the hands or the soles of the feet.


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Infectious mononucleosis (mono) is often called the kissing disease. The virus that causes mono is transmitted through saliva, so you can get it through kissing, but you can also be exposed through a cough or sneeze, or by sharing a glass or food utensils with someone who has mono. However, mononucleosis isn't as contagious as some infections, such as the common cold.You're most likely to get mononucleosis with all the signs and symptoms if you're an adolescent or young adult. Young children usually have few symptoms, and the infection often goes unrecognized.If you have mononucleosis, it's important to be careful of certain complications such as an enlarged spleen. Rest and adequate fluids are key to recovery.

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Mouth cancer, also known as oral cancer, is where a tumour develops in the lining of the mouth. It may be on the surface of the tongue, the insides of the cheeks, the roof of the mouth (palate), or the lips or gums.Tumours can also develop in the glands that produce saliva, the tonsils at the back of the mouth, and the part of the throat connecting your mouth to your windpipe (pharynx). However, these are less common.

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Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Plasma cells help you fight infections by making antibodies that recognize and attack germs.Multiple myeloma causes cancer cells to accumulate in the bone marrow, where they crowd out healthy blood cells. Rather than produce helpful antibodies, the cancer cells produce abnormal proteins that can cause complications.Treatment for multiple myeloma isn't always necessary for people who aren't experiencing any signs or symptoms. For people with multiple myeloma who require treatment, a number of treatments are available to help control the disease.

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Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system).In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged.Signs and symptoms of MS vary widely and depend on the amount of nerve damage and which nerves are affected. Some people with severe MS may lose the ability to walk independently or at all, while others may experience long periods of remission without any new symptoms.There's no cure for multiple sclerosis. However, treatments can help speed recovery from attacks, modify the course of the disease and manage symptoms.

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Myoclonus refers to a sudden, brief, and involuntary muscle jerk. Healthy people can have myoclonus in the form of hiccups and “sleep starts”, which are the sudden jerky sensations that can occur as people fall asleep. Myoclonus can also occur due to underlying neurological disorders such as epilepsy, metabolic conditions, or adverse reactions to medications. Importantly, myoclonus is a symptom, not a diagnosis of a disease.Sudden positive muscle contractions are called positive myoclonus, whereas muscle relaxation is called negative myoclonus. Myoclonus can vary in frequency, and can occur alone or in a sequence. There are several underlying conditions that can give rise to myoclonus symptoms. Doctors aim to isolate and treat the underlying cause of myoclonus symptoms. When the underlying cause cannot be treated or cured, the aim of treatment is to alleviate severe myoclonus

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Neurodermatitis is a skin condition that begins with an itch.The itch can develop anywhere on the surface of the body. Most commonly, though, an itchy patch develops on an arm, leg, or the back of the neck. It also commonly develops in the anal and genital areas. When it appears in the genital area, it often appears on the scrotum or vulva.The itch can be so intense that a person scratches or rubs the itchy patch frequently. The itch can also come and go. For most people, the area feels itchiest when they are relaxing or sleeping. The itch causes people to scratch or rub the area while sleeping — and it can awaken someone from a sound sleep.Quite often, the itch begins during an especially stressful time in someone’s life. Even when the stress subsides, the itch usually continues. Scratching or rubbing can change the appearance of that itchy patch.

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Neuroendocrine tumors are abnormal growths that begin in specialized cells called neuroendocrine cells. Neuroendocrine cells have traits similar to nerve cells and to hormone-producing cells.Neuroendocrine tumors are rare and can occur anywhere in the body. Most neuroendocrine tumors occur in the lungs, appendix, small intestine, rectum and pancreas.Neuroendocrine tumors can be noncancerous (benign) or cancerous (malignant).Diagnosis and treatment of neuroendocrine tumors depend on the type of tumor, its location, whether it produces excess hormones, how aggressive it is and whether it has spread to other parts of the body

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Neurofibromatosis is a genetic disorder that causes tumors to form on nerve tissue. These tumors can develop anywhere in your nervous system, including your brain, spinal cord and nerves. Neurofibromatosis is usually diagnosed in childhood or early adulthood.The tumors are usually noncancerous (benign), but sometimes can become cancerous (malignant). Symptoms are often mild. However, complications of neurofibromatosis can include hearing loss, learning impairment, heart and blood vessel (cardiovascular) problems, loss of vision, and severe pain.Neurofibromatosis treatment aims to maximize healthy growth and development and to manage complications as soon as they arise. When neurofibromatosis causes large tumors or tumors that press on a nerve, surgery can help ease symptoms. Some people may benefit from other therapies, such as stereotactic radiosurgery or medications to control pain.

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Nonulcer stomach pain is a term for recurring signs and symptoms of indigestion that have no obvious cause. Nonulcer stomach pain is also called functional dyspepsia (dis-PEP-see-uh) or nonulcer dyspepsia.Nonulcer stomach pain is common and can be long lasting. The condition can cause signs and symptoms that resemble those of an ulcer, such as pain or discomfort in your upper abdomen, often accompanied by bloating, belching and nausea.

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Norovirus infection can cause the sudden onset of severe vomiting and diarrhea. The virus is highly contagious and commonly spread through food or water that is contaminated during preparation or contaminated surfaces. You can also be infected through close contact with an infected person.Diarrhea, abdominal pain and vomiting typically begin 12 to 48 hours after exposure. Norovirus symptoms last one to three days, and most people recover completely without treatment. However, for some people — especially infants, older adults and people with underlying disease — vomiting and diarrhea can be severely dehydrating and require medical attention.Norovirus infection occurs most frequently in closed and crowded environments such as hospitals, nursing homes, child care centers, schools and cruise ships.

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Occupational asthma is asthma that's caused or worsened by breathing in chemical fumes, gases, dust or other substances on the job. Like other types of asthma, occupational asthma can cause chest tightness, wheezing and shortness of breath.When treated early, occupational asthma may be reversible. Long-term exposure to allergy-causing substances can cause worsening symptoms and lifelong asthma.Treatment for occupational asthma is similar to treatment for other types of asthma, and it generally includes taking medications to reduce symptoms. But the only sure way to eliminate your symptoms and prevent lung damage due to occupational asthma is to avoid whatever's triggering it.

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Ocular rosacea is inflammation that causes redness, burning and itching of the eyes. It often develops in people who have rosacea, a chronic skin condition that affects the face. Sometimes ocular, or eye, rosacea is the first sign that you may later develop the facial type.Ocular rosacea (roe-ZAY-she-uh) primarily affects adults between the ages of 30 and 50. It seems to develop in people who tend to blush and flush easily.Medications and a good eye-care routine can help control the signs and symptoms. But treatment doesn't cure ocular rosacea. It often recurs after an apparent remission.

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Optic neuritis is an inflammation that damages the optic nerve, a bundle of nerve fibers that transmits visual information from your eye to your brain. Pain and temporary vision loss in one eye are common symptoms of optic neuritis.

Optic neuritis is linked to multiple sclerosis (MS), a disease that causes inflammation and damage to nerves in your brain and spinal cord. Signs and symptoms of optic neuritis can be the first indication of multiple sclerosis, or they can occur later in the course of MS. Besides MS, optic neuritis can occur with other infections or immune diseases, such as lupus.

Most people who have a single episode of optic neuritis eventually recover their vision. Treatment with steroid medications may speed up vision recovery after optic neuritis.

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Lichen planus is an itchy skin rash that is caused by an immune response. It can occur anywhere on your skin.oral lichen planusIn cases of oral lichen planus, the mucous membranes inside your mouth are the only area affected. Oral lichen planus presents symptoms different from other cases of lichen planus. Instead of a rash, people may experience swollen tissues, white patches, and open sores.Oral lichen planus isn’t contagious, and it can’t be spread to another person.

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Oral thrush — also called oral candidiasis (kan-dih-DIE-uh-sis) — is a condition in which the fungus Candida albicans accumulates on the lining of your mouth. Candida is a normal organism in your mouth, but sometimes it can overgrow and cause symptoms.Oral thrush causes creamy white lesions, usually on your tongue or inner cheeks. Sometimes oral thrush may spread to the roof of your mouth, your gums or tonsils, or the back of your throat.Although oral thrush can affect anyone, it's more likely to occur in babies and older adults because they have reduced immunity; in other people with suppressed immune systems or certain health conditions; or people who take certain medications. Oral thrush is a minor problem if you're healthy, but if you have a weakened immune system, symptoms may be more severe and difficult to control.


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Both benign (non-cancerous) and cancerous salivary gland tumors may develop anywhere in the salivary glands, but the majority of them are parotid tumors. In fact, as many as 80% of salivary gland tumors begin in the parotid glands. 15% occur in the submandibular glands, and 5% form in the sublingual and minor glands. While most salivary gland tumors occur in the parotid glands, only 20% of them are cancerous. With this in mind, we want to stress that it is important that you come see us if you are find a mass in your parotid gland so we can perform a biopsy. This will allow us to determine whether a growth is cancerous or not, and in turn come up with a treatment plan that may require parotid surgery on the tumor.

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Parvovirus infection is a common and highly contagious childhood ailment — sometimes called slapped-cheek disease because of the distinctive face rash that develops. Parvovirus infection has also been known as fifth disease because, historically, it was one of five common childhood illnesses characterized by a rash.In most children, parvovirus infection is mild and requires little treatment. However, in some adults, the infection can be serious. Parvovirus infection in some pregnant women can lead to serious health problems for the fetus. Parvovirus infection is also more serious for people with some kinds of anemia or who have a compromised immune system.

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Many schools have declared that they are “nut-free,” meaning that the onetime staple of kids’ lunchboxes — a peanut butter and jelly sandwich — is nowhere to be found on school grounds these days. That’s because peanuts can cause a life-threatening reaction in some people. Peanuts are one of the food allergens most commonly associated with anaphylaxis, a sudden and potentially deadly condition that requires immediate attention and treatment.In recent years, awareness about peanut allergy in children has risen, as has the number of peanut allergy cases reported. In May 2010, a study noted that the rate of peanut allergies in children, as reported in a telephone survey, had more than tripled between 1997 and 2008.There are several misconceptions about peanut allergies. A peanut is a legume (belonging to the same family as soybeans, peas and lentils), not a tree nut. And while it was previously believed that an allergy to peanuts was lifelong, research by the National Institutes of Health shows that about 20 percent of individuals with a peanut allergy eventually outgrow it.


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Pectus carinatum, sometimes called pigeon chest, is a non-life-threatening condition. It’s marked by an abnormally outward protruding breastbone caused by rapid cartilage growth forcing the chest cavity outward. Occasionally, symptoms are present from birth or early childhood, but it’s most commonly diagnosed around 11 or 12 years of age.For most children, pectus carinatum is an aesthetic issue only. This condition frequently results in an asymmetrical chest. In more severe cases, symptoms may also include difficulty breathing during physical activities, recurring respiratory infections, and asthma.While its cause is unknown, it appears to be more common in boys, and there seems to be a hereditary component. If needed, treatment for pectus carinatum usually includes wearing a brace for children whose bones are still developing. But it can also include surgery for severe cases.

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Pectus excavatum is a condition in which a person's breastbone is sunken into his or her chest. In severe cases, pectus excavatum can look as if the center of the chest has been scooped out, leaving a deep dent.While the sunken breastbone is often noticeable shortly after birth, the severity of pectus excavatum typically worsens during the adolescent growth spurt.Also called funnel chest, pectus excavatum is more common in boys than in girls. Severe cases of pectus excavatum can eventually interfere with the function of the heart and lungs. But even mild cases of pectus excavatum can make children feel self-conscious about their appearance. Surgery can correct the deformity.

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Pediatric brain tumors are masses or growths of abnormal cells that occur in a child's brain or the tissue and structures that are near it. Many different types of pediatric brain tumors exist — some are noncancerous (benign) and some are cancerous (malignant).Treatment and chance of recovery (prognosis) depend on the type of tumor, its location within the brain, whether it has spread, and your child's age and general health. Because new treatments and technologies are continually being developed, several options may be available at different points in treatment.Treatment for brain tumors in children is typically quite different from treatment for adult brain tumors, so it's very important to enlist the expertise and experience of pediatric specialists in neurology and cancer.

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Pemphigus is a group of rare skin disorders that cause blisters and sores on the skin or mucous membranes, such as in the mouth or on the genitals.The two main types are pemphigus vulgaris and pemphigus foliaceus. Pemphigus vulgaris usually starts in your mouth. It can be painful. Pemphigus foliaceus affects the skin and tends to be more itchy than painful. Pemphigus can occur at any age, but it's most often seen in people who are middle-aged or older.Pemphigus is not to be confused with bullous pemphigoid, another blistering skin condition. Usually a chronic condition, pemphigus is best controlled by early diagnosis and treatment. Treatment may include medications and therapies similar to those used for severe burns

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An “ulcer” is an open sore. The word “peptic” means that the cause of the problem is due to acid. Most of the time when a gastroenterologist is referring to an “ulcer” the doctor means a peptic ulcer.The two most common types of peptic ulcer are called “gastric ulcers” and “duodenal ulcers”. These names refer to the location where the ulcer is found. Gastric ulcers are located in the stomach (see Figure 1). Duodenal ulcers are found at the beginning of the small intestine (also called the small bowel) known as the duodenum. A person may have both gastric and duodenal ulcers at the same time.

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Dark underarms can be defined as the dark coloration of skin in the underarm region compared to the rest of the body. It is a problem many individuals find embarrassing. Ascertaining the reason can help to alleviate the problem effectively. 

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Pericardial effusion (per-e-KAHR-dee-ul uh-FU-zhun) is the accumulation of too much fluid in the double-layered, sac-like structure around the heart (pericardium).The space between the layers normally contains a thin layer of fluid. But if the pericardium is diseased or injured, the resulting inflammation can lead to excess fluid. Fluid can also build up around the heart without inflammation, such as from bleeding after a chest trauma.Pericardial effusion puts pressure on the heart, affecting the heart's function. If untreated, it can lead to heart failure or death

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Perimenopause means "around menopause" and refers to the time during which your body makes the natural transition to menopause, marking the end of the reproductive years. Perimenopause is also called the menopausal transition.Women start perimenopause at different ages. You may notice signs of progression toward menopause, such as menstrual irregularity, sometime in your 40s. But some women notice changes as early as their mid-30s.

The level of estrogen — the main female hormone — in your body rises and falls unevenly during perimenopause. Your menstrual cycles may lengthen or shorten, and you may begin having menstrual cycles in which your ovaries don't release an egg (ovulate). You may also experience menopause-like symptoms, such as hot flashes, sleep problems and vaginal dryness. Treatments are available to help ease these symptoms.Once you've gone through 12 consecutive months without a menstrual period, you've officially reached menopause, and the perimenopause period is over.

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njuries to peripheral nerves are extremely common in many types of upper limb trauma. Injury to peripheral nerves can cause extreme dysfunction in the hand for the patient disrupting their professional and leisure activities. It is therefore vital that adequate treatment is available to repair peripheral nerves to prevent permanent financial loss for the patient as well as the healthcare economy. Galen was the first to describe the concept of the nerve but it was Paulus Aegineta in the 7th century who documented the first nerve repair and wound closure as a military surgeon. Since this time immense research has taken place to understand nerve pathology and physiology. Currently surgical repair involves either reconstruction with direct end-to-end anastomosis or by the insertion of nerve grafts. Despite the long history and major microsurgical research and improvement peripheral nerve repair remains a challenge to surgeons and still has suboptimal outcomes. This review aims to discuss the pathophysiology of nerve injuries including the limitations of surgical repair at a biological level. We will subsequently describe the current techniques, problems and advances in the surgical management of nerve injuries.


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Peripheral nerve tumors are growths in or near the strands of tissue (nerves) that transmit signals from your brain to the rest of your body. These nerves control your muscles so that you can walk, blink, swallow, pick things up and do other activities.Peripheral nerve tumors can occur anywhere in the body. Most of them aren't cancerous (malignant), but they can lead to pain, nerve damage and loss of function in the affected area.Treatment of peripheral nerve tumors usually involves surgery to remove the tumor. Sometimes the tumor can't be removed without damaging nearby healthy tissue and nerves. In these cases, other treatments may be recommended.Several types of peripheral nerve tumors occur. These tumors affect nerves by growing within them (intraneural tumors) or by pressing against them (extraneural tumors).

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Peripheral neuropathy, a result of damage to your peripheral nerves, often causes weakness, numbness and pain, usually in your hands and feet. It can also affect other areas of your body.

Your peripheral nervous system sends information from your brain and spinal cord (central nervous system) to the rest of your body. Peripheral neuropathy can result from traumatic injuries, infections, metabolic problems, inherited causes and exposure to toxins. One of the most common causes is diabetes mellitus.

People with peripheral neuropathy generally describe the pain as stabbing, burning or tingling. In many cases, symptoms improve, especially if caused by a treatable condition. Medications can reduce the pain of peripheral neuropathy.


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Phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. Phenylalanine is a building block of proteins (an amino acid) that is obtained through the diet. It is found in all proteins and in some artificial sweeteners. If PKU is not treated, phenylalanine can build up to harmful levels in the body, causing intellectual disability and other serious health problems.The signs and symptoms of PKU vary from mild to severe. The most severe form of this disorder is known as classic PKU. Infants with classic PKU appear normal until they are a few months old. Without treatment, these children develop permanent intellectual disability. Seizures, delayed development, behavioral problems, and psychiatric disorders are also common. Untreated individuals may have a musty or mouse-like odor as a side effect of excess phenylalanine in the body. Children with classic PKU tend to have lighter skin and hair than unaffected family members and are also likely to have skin disorders such as eczema.


Less severe forms of this condition, sometimes called variant PKU and non-PKU hyperphenylalaninemia, have a smaller risk of brain damage. People with very mild cases may not require treatment with a low-phenylalanine diet.Babies born to mothers who have PKU and uncontrolled phenylalanine levels (women who no longer follow a low-phenylalanine diet) have a significant risk of intellectual disability because they are exposed to very high levels of phenylalanine before birth. These infants may also have a low birth weight and grow more slowly than other children. Other characteristic medical problems include heart defects or other heart problems, an abnormally small head size (microcephaly), and behavioral problems. Women with PKU and uncontrolled phenylalanine levels also have an increased risk of pregnancy loss.


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Pink eye (conjunctivitis) is an inflammation or infection of the transparent membrane (conjunctiva) that lines your eyelid and covers the white part of your eyeball. When small blood vessels in the conjunctiva become inflamed, they're more visible. This is what causes the whites of your eyes to appear reddish or pink.

Pink eye is commonly caused by a bacterial or viral infection, an allergic reaction, or — in babies — an incompletely opened tear duct.Though pink eye can be irritating, it rarely affects your vision. Treatments can help ease the discomfort of pink eye. Because pink eye can be contagious, early diagnosis and treatment can help limit its spread.

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Pituitary tumors are abnormal growths that develop in your pituitary gland. Some pituitary tumors result in too many of the hormones that regulate important functions of your body. Some pituitary tumors can cause your pituitary gland to produce lower levels of hormones.Most pituitary tumors are noncancerous (benign) growths (adenomas). Adenomas remain in your pituitary gland or surrounding tissues and don't spread to other parts of your body.There are various options for treating pituitary tumors, including removing the tumor, controlling its growth and managing your hormone levels with medications. Your doctor may recommend observation — or a ''wait and see'' approach.



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A placental abruption is a serious condition in which the placenta partially or completely separates from your uterus before your baby's born.The condition can deprive your baby of oxygen and nutrients, and cause severe bleeding that can be dangerous to you both. A placental abruption also increases the risk that your baby will have growth problems (if the abruption is small and goes unnoticed), be born prematurely, or be stillborn.Placental abruption happens in about one in 150 pregnancies. It's most common in the third trimester but can happen any time after 20 weeks.


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When you breathe, the thin tissues that line your lungs and chest wall, called the pleura, rub together. Typically this isn’t a problem, because the tissue is satiny and generates no friction. However, when this tissue is inflamed or infected, it becomes irritated and swollen, causing significant pain. This condition is known as pleurisy or pleuritis.This condition has a grim fame. It caused the death of a number of historical figures, including Catherine de Medici and Benjamin Franklin.Pleurisy is no longer a common condition. Over the years, antibiotics have been extremely successful in treating and preventing the bacterial infections that historically were the main causes of pleurisy. Nowadays, most cases of pleurisy are the result of a viral infection and deaths from this illness are quite rare.


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Pneumonitis is a general term for inflammation of lung tissue. Chronic inflammation of lung tissue can lead to irreversible scarring (pulmonary fibrosis). Pneumonitis is not a specific disease but a sign of an underlying problem.Acute chemical pneumonitis causes swelling of the lung tissue, movement of fluid into the air spaces in the lung and reduced ability to absorb oxygen and remove carbon dioxide. In severe cases, death may result from hypoxia.Chronic pneumonitis may follow low levels of exposure to the irritant over long periods of time, causing inflammation which may lead to fibrosis, resulting in decreased gas exchange and stiffening of the lung, and ultimately leading to respiratory failure and death.


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A pneumothorax (noo-moe-THOR-aks) is a collapsed lung. A pneumothorax occurs when air leaks into the space between your lung and chest wall. This air pushes on the outside of your lung and makes it collapse. In most cases, only a portion of the lung collapses.A pneumothorax can be caused by a blunt or penetrating chest injury, certain medical procedures, or damage from underlying lung disease. Or it may occur for no obvious reason. Symptoms usually include sudden chest pain and shortness of breath. On some occasions, a collapsed lung can be a life-threatening event.Treatment for a pneumothorax usually involves inserting a flexible tube or needle between the ribs to remove the excess air. However, a small pneumothorax may heal on its own.

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Polymyalgia rheumatica (sometimes referred to as PMR) is a common cause of widespread aching and stiffness that affects adults over the age of 50, especially Caucasians. Because polymyalgia rheumatica does not often cause swollen joints, it may be hard to recognize. It may occur with another health problem, giant cell arteritis.


The average age when symptoms start is 70, so people who have PMR may be in their 80s or even older. The disease affects women somewhat more often than men. It is more frequent in whites than nonwhites, but all races can get PMR.

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Postherpetic neuralgia (also termed PHN) is a condition of recurring or persistent pain in an area of the body that has undergone an outbreak of herpes zoster virus (HZ), also known as the varicella zoster virus, commonly termed shingles. It usually begins after shingles lesions (blisters) begin to crust over and heal but may occur in some patients who do not produce lesions. Some investigators suggest the pain has to be present for three months to be termed PHN.


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Postpartum preeclampsia is a rare condition that can develop soon after birth (usually within the first 48 to 72 hours after delivery) and is marked by high blood pressure and excess protein in the urine. In rare cases, preeclampsia onset can be delayed up to about one month postpartum; it is usually called late postpartum preeclampsia if the onset is more than 48 hours postpartum. "It takes time for the uterus to shed its lining after birth, so this process may be behind the delay that's sometimes seen in late onset preeclampsia after delivery," says James N. Martin, M.D., past president of the American College of Obstetricians and Gynecologists. It's also possible this condition begins during pregnancy but doesn't show signs or symptoms until after the baby has arrived.


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Postpartum thyroiditis is an exacerbation of an underlying autoimmune thyroiditis, aggravated by the immunological rebound that follows the partial immunosuppression of pregnancy (1–3). Women who express human leukocyte antigen haplotypes DR-3, DR-4, and DR-5 have an increased risk for postpartum thyroiditis. In women who develop postpartum thyroiditis, CD4+/CD8+ and CD4 + 2H4+ ratios are elevated throughout pregnancy and the postpartum (4). Histologically, thyroid aspirates reveal either a lymphocytic infiltrate or diffuse destruction, changes similar to those seen in both Hashimoto’s thyroiditis (2, 3, 5) and painless sporadic silent thyroiditis (6). In essence, the immunological rebound that follows the end of pregnancy precipitates the clinical expression of Hashimoto’s disease, which before pregnancy was clinically silent

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After a patient has had a total proctocolectomy (removal by surgery of the large intestine and rectum), a procedure called ileal pouch-anal anastomosis (IPAA) is performed. In an IPAA, the ileum, or lowest part of the small intestine, is connected to the anus to create a structure (pouch) that can store and eliminate stools.


The surgeon creates a J-pouch (which resembles the letter J) to provide for the storage area. Other pouch shapes (S and K) are also possible. The pouch helps improve the patient’s quality of life and reduces the risk of growths that could develop into cancer. However, after this surgery, some patients may get pouchitis.


Pouchitis is an inflammation (swelling) of the pouch that occurs when the pouch becomes irritated and inflamed. The inflammation can cause increased bowel frequency (having to go to the bathroom more often), abdominal cramping or bloating, lower abdominal pain, or sometimes blood in the stool. This condition should be evaluated and managed by an experienced gastroenterologist.

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Precocious puberty is when a child's body begins changing into that of an adult (puberty) too soon. Puberty that begins before age 8 in girls and before age 9 in boys is considered precocious puberty.


Puberty includes rapid growth of bones and muscles, changes in body shape and size, and development of the body's ability to reproduce.


The cause of precocious puberty often can't be found. Rarely, certain conditions, such as infections, hormone disorders, tumors, brain abnormalities or injuries, may cause precocious puberty. Treatment for precocious puberty typically includes medication to delay further development.

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A premature baby is one who is born too early, before 37 weeks. Premature babies may have more health problems and may need to stay in the hospital longer than babies born later. 


They also may have long-term health problems that can affect their whole lives. About 1 in 10 babies is born prematurely each year in the United States. 


The earlier in pregnancy a baby is born, the more likely he is to have health problems. Some premature babies have to spend time in a hospital’s neonatal intensive care unit (also called NICU). This is the part of a hospital that takes care of sick newborns. But thanks to advances in medical care, even babies born very prematurely are more likely to survive today than ever before.

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Premature ejaculation is uncontrolled ejaculation either before or shortly after sexual penetration. It happens with minimal sexual stimulation and before the person wishes. It may result in unsatisfactory sex for both partners. This can increase the anxiety that may add to the problem. It is one of the most common forms of male sexual dysfunction. It has probably affected every man at some point in his life.


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Premature ovarian failure — also known as primary ovarian insufficiency — is a loss of normal function of your ovaries before age 40. If your ovaries fail, they don't produce normal amounts of the hormone estrogen or release eggs regularly. Infertility is a common result.


Premature ovarian failure is sometimes referred to as premature menopause, but the two conditions aren't the same. Women with premature ovarian failure can have irregular or occasional periods for years and might even become pregnant. Women with premature menopause stop having periods and can't become pregnant.


Restoring estrogen levels in women with premature ovarian failure helps prevent some complications, such as osteoporosis, that occur as a result of low estrogen.

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Abusing some prescription drugs can lead to addiction. These include opioids, sedatives, tranquilizers, and stimulants.


Every medicine has some risk of side effects. Doctors take this into account when prescribing medicines. People who abuse these drugs may not understand the risks. The medicines may not be safe for them, especially at higher doses or when taken with other medicines.

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When your child has a primary immunodeficiency disease (PIDD), his body has a harder time fighting germs that make people sick. He may get a lot of infections in his ears, lungs, skin, or other areas that take a long time to go away.

Most cases happen in babies or young children, but sometimes it doesn't show up until adulthood. There are many different types -- more than 200 -- and they affect different parts of the immune system. All make it more likely that he'll get sick from infections.

Everyone with a PIDD has a different experience. If your child has it, in most cases he'll be able to go to school and make friends like other kids. As an adult with a PIDD, he'll be able to work and have an active, normal life.

If your child's PIDD is mild, he may need to take medicines to treat the infections he gets.

Doctors treat some of the more serious types of PIDD with doses of antibodies to fight infections. He'll get these antibodies through an IV in his veins. The treatment takes several hours, and he'll need one every few weeks.

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Pseudobulbar affect (PBA) is a condition that’s characterized by episodes of sudden uncontrollable and inappropriate laughing or crying. Pseudobulbar affect typically occurs in people with certain neurological conditions or injuries, which might affect the way the brain controls emotion.

If you have pseudobulbar affect you'll experience emotions normally, but you'll sometimes express them in an exaggerated or inappropriate way. As a result, the condition can be embarrassing and disruptive to your daily life.

Pseudobulbar affect often goes undiagnosed or is mistaken for mood disorders. Once diagnosed, however, pseudobulbar affect can be managed with medication.

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Pseudogout is a type of inflammation of joints (arthritis) that is caused by deposits of crystals, called calcium pyrophosphate, in and around the joints. Pseudogout literally means "false gout." It derives its name from its similarity to gout.

Pseudogout has many similarities to true gout, which also can cause arthritis. However, the crystal that incites the inflammation of gout is monosodium urate. The crystals that cause pseudogout and gout each have distinct appearances when joint fluid containing them is viewed under a microscope. This makes it possible to precisely identify the cause of the joint inflammation when joint fluid is available.

Pseudogout has been reported to occasionally coexist with gout. This means that the two types of crystals can sometimes be found in the same joint fluid. Researchers have also noted that the cartilage of patients who had both forms of crystals in their joint fluid was often visibly calcified, as seen on X-ray images.

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Pseudomembranous colitis (PMC) is inflammation in your colon that happens when there's too much of certain bacteria in your system. The most common bacterium that causes PMC isClostridium difficile, or C. diff.

PMC is also called antibiotic-associated colitis or C. difficilecolitis. Most of the time, it's a side effect of taking antibiotics.

People in hospitals or nursing homes also can get PMC, especially if they've just had surgery or are receiving treatment for cancer.

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Pseudotumor cerebri is a condition in which the pressure around your brain increases, causing headaches and vision problems. The name means “false brain tumor” because its symptoms are similar to those caused by brain tumors. It’s also known as idiopathic intracranial hypertension. This condition is treatable, but it can return in some cases.

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Pulmonary atresia is a form of heart disease in which the pulmonary valve does not form properly. It is present from birth (congenital heart disease). The pulmonary valve is an opening on the right side of the heart that regulates blood flow from the right ventricle (right side pumping chamber) to the lungs.


In pulmonary atresia, a solid sheet of tissue forms where the valve opening should be, and the valve stays closed. Because of this defect, blood from the right side of the heart cannot go to the lungs to pick up oxygen.

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Edema, in general, means swelling. This typically occurs when fluid from inside blood vessels seeps outside the blood vessel into the surrounding tissues, causing swelling. This can happen either because of too much pressure in the blood vessels or not enough proteins in the bloodstream to hold on to the fluid in the plasma (the part of the blood that does not contain any blood cells).


Pulmonary edema is the term used when edema happens in the lungs. The immediate area outside of the small blood vessels in the lungs is occupied by very tiny air sacs called the alveoli. This is where oxygen from the air is picked up by the blood passing by, and carbon dioxide in the blood is passed into the alveoli to be exhaled out. Alveoli normally have a thin wall that allows for this air exchange, and fluids are usually kept out of the alveoli unless these walls lose their integrity.

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Pulmonary embolism is a blockage in one of the pulmonary arteries in your lungs. In most cases, pulmonary embolism is caused by blood clots that travel to the lungs from the legs or, rarely, other parts of the body (deep vein thrombosis).


Because the clots block blood flow to the lungs, pulmonary embolism can be life-threatening. However, prompt treatment greatly reduces the risk of death. Taking measures to prevent blood clots in your legs will help protect you against pulmonary embolism.


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The pulmonic valve is one of two valves that allow blood to leave the heart via the arteries. It is a one-way valve, meaning that blood cannot flow back into the heart through it. The valve is opened by the increased blood pressure of the ventricular systole (contraction of the muscular tissue), pushing blood out of the heart and into the artery. It closes when the pressure drops inside the heart. It is located in the right ventricle of the heart. The pulmonic valve opens into the pulmonary artery. The frequency of this cycle depends upon the heart rate. Pulmonary stenosis is a condition where the blood flow out of the heart is obstructed at the pulmonic valve. The most common cause of this is congenital heart disease, although rheumatic heart disease and a malignant carcinoid tumor can also initiate the problem. The condition is treated by surgical repair or replacement of the pulmonic valve.

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Pulmonary valve stenosis is a condition in which a deformity on or near your pulmonary valve narrows the pulmonary valve opening and slows the blood flow. The pulmonary valve is located between the lower right heart chamber (right ventricle) and the pulmonary arteries. Adults occasionally have pulmonary valve stenosis as a complication of another illness, but mostly, pulmonary valve stenosis develops before birth as a congenital heart defect.


Pulmonary valve stenosis ranges from mild and without symptoms to severe. Mild pulmonary stenosis doesn't usually worsen over time, but moderate and severe cases may worsen and require surgery. Fortunately, treatment is generally highly successful, and most people with pulmonary valve stenosis can expect to lead normal lives.

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Pyoderma gangrenosum is an uncommon, ulcerative cutaneous condition of uncertain etiology. It is associated with systemic diseases in at least 50% of patients who are affected. [1, 2] The diagnosis is made by excluding other causes of similar-appearing cutaneous ulcerations, including infection, malignancy, vasculitis, collagen vascular diseases, diabetes, and trauma. In a process termed pathergy, new ulcerations may occur after trauma or injury to the skin in 30% of patients who already have pyoderma gangrenosum. (See Presentation, DDx, and Workup.)Patients with pyoderma gangrenosum may have involvement of other organ systems that manifests as sterile neutrophilic infiltrates. Culture-negative pulmonary infiltrates are the most common extracutaneous manifestation. [3] Other organs systems that may be involved include the heart, the central nervous system, the gastrointestinal (GI) tract, the eyes, [4, 5] the liver, the spleen, the bones, and the lymph nodes. (See Presentation and Workup.)n Therapy for pyoderma gangrenosum involves the use of anti-inflammatory agents, including antibiotics, corticosteroids, immunosuppressive agents, and biologic agents. The prognosis is generally good; however, the disease can recur and residual scarring is common. (See Prognosis, Treatment, and Medication.)


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Ramsay Hunt syndrome happens when shingles affects nerves in your face close to either one of your ears. Shingles affecting either ear is a condition caused by a virus called herpes zoster oticus. The general varicella-zoster virus also causes chicken pox, which is most common in children. If you’ve had chicken pox in your life, the virus can reactivate later in your life and cause shingles. Both shingles and chicken pox are most recognizable by a rash that appears in the affected area of the body. Unlike chicken pox, a shingles rash near the facial nerves by your ears can cause other complications, including facial paralysis and ear pain. When this happens, it’s called Ramsay Hunt syndrome. If you get a rash on your face and also start noticing symptoms such as facial muscle weakness, see your doctor as soon as you can. Early treatment can help make sure you don’t experience any complications from Ramsay Hunt syndrome.

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Raynaud's (ray-NOHZ) disease causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. In Raynaud's disease, smaller arteries that supply blood to your skin narrow, limiting blood circulation to affected areas (vasospasm). Women are more likely than men to have Raynaud's disease, also known as Raynaud or Raynaud's phenomenon or syndrome. It appears to be more common in people who live in colder climates. Treatment of Raynaud's disease depends on its severity and whether you have other health conditions. For most people, Raynaud's disease isn't disabling, but it can affect your quality of life.

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When the occasional headache strikes, most of us take an over-the-counter (OTC) analgesic, such as acetaminophen, ibuprofen, aspirin, or a pain-relief medication containing caffeine. While OTC analgesics can help relieve headache pain they must be taken correctly — or they could actually make your headaches worse. The overuse or misuse of analgesic drugs — exceeding labeling instructions (such as taking the medications three or more days per week) or not following your healthcare provider’s advice — can cause you to "rebound" into another headache. When the pain reliever wears off, you may experience a withdrawal reaction, prompting you to take more medication. This only leads to another headache and the desire to take yet more medication. So the cycle continues until you start to suffer from chronic daily headaches, with more frequent headaches and more severe pain.

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A rectovaginal fistula (RVF) is an epithelial-lined tract between the rectum and vagina. For thousands of years, women simply tolerated the distressing symptoms generated by RVFs. Today, there is no need for such tolerance, because most RVFs can be surgically corrected via a number of approaches. [1] A small percentage, however, cannot be corrected, because of patient comorbidity or disease-related factors; in these cases, patients can be helped only by fecal diversion. [2]  This article discusses only acquired RVFs. Most RVFs are located at or just above the dentate line. Fistulas below the dentate line are not true RVFs but, rather, anovaginal fistulas; the treatment required for these differs from that required for RVFs.

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Ejaculation is the ejection of semen out of the urethra (passageway inside the penis) when a man has an orgasm. Under normal circumstances, ejaculation propels semen forward through a man's urethra and out the tip of his penis. This is because a tiny sphincter (circular muscle) at the entrance to the bladder shuts the opening to the bladder and prevents semen from entering. Retrograde ejaculation is when the semen travels backwards into the bladder.


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Rheumatic fever is one of the complications associated with strep throat. It’s a relatively serious illness that can cause stroke, permanent damage to your heart, and death if it’s left untreated. The condition usually appears in children between the ages of 5 and 15, even though older children and adults have been known to contract the fever as well. It’s still common in places like sub-Saharan Africa, south central Asia, and certain populations in Australia and New Zealand.


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The rotator cuff is a group of muscles and tendons that surround the shoulder joint, keeping the head of your upper arm bone firmly within the shallow socket of the shoulder. A rotator cuff injury can cause a dull ache in the shoulder, which often worsens when you try to sleep on the involved side.Rotator cuff injuries occur most often in people who repeatedly perform overhead motions in their jobs or sports. Examples include painters, carpenters, and people who play baseball or tennis. The risk of rotator cuff injury also increases with age.Many people recover from rotator cuff disease with physical therapy exercises that improve flexibility and strength of the muscles surrounding the shoulder joint.Sometimes, rotator cuff tears may occur as a result of a single injury. In those circumstances, medical care should be provided as soon as possible. Extensive rotator cuff tears may require surgical repair, transfer of alternative tendons or joint replacement


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Rubella is an acute, contagious viral infection. While rubella virus infection usually causes a mild fever and rash illness in children and adults, infection during pregnancy, especially during the first trimester, can result in miscarriage, fetal death, stillbirth, or infants with congenital malformations, known as congenital rubella syndrome (CRS). The rubella virus is transmitted by airborne droplets when infected people sneeze or cough. Humans are the only known host.


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Rumination syndrome, or Merycism, is a rare disorder that affects children and some adults. If your child has this condition, he or she will usually eat meals normally. But after about an hour or two, undigested food comes back up into his or her mouth from the esophagus. Your child will either rechew and reswallow the food, or spit it out. Typically this happens at every meal, day after day. Rumination is a reflex, not a conscious decision.


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The spleen is an organ of the lymphatic system located on the left side of your stomach (abdomen) under the rib cage and diaphragm in a region that is referred to as the left upper quadrant. In humans the spleen is about the size of a fist and its primary roles are filtering the body’s blood and helps to fight infection. It also serves a role in storing and releasing certain types of immune cells that mediate tissue inflammation. [1]Rupturing a spleen describes an emergency situation in which your spleen has developed a disruption in its surface or blood supply. This is serious condition that can occur during a direct blow or trauma and without emergency treatment a ruptured spleen can cause life threatening internal bleeding. [2]


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Salivary gland tumors are rare types of tumors that begin in the salivary glands.


Salivary gland tumors can begin in any of the salivary glands in your mouth, neck or throat. Salivary glands make saliva, which aids in digestion, keeps your mouth moist and supports healthy teeth.


You have three pairs of major salivary glands under and behind your jaw — parotid, sublingual and submandibular. Many other tiny salivary glands are in your lips, inside your cheeks, and throughout your mouth and throat.


Salivary gland tumors most commonly occur in the parotid gland, accounting for nearly 85 percent of all salivary gland tumors. Approximately 25 percent of parotid tumors are cancerous (malignant).


Treatment for salivary gland tumors often involves surgery. Treatments for salivary gland tumors may also include radiation therapy and chemotherapy.

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Sebaceous glands are part of epidermal appendages. Neoplasms of the sebaceous glands may be benign, such as sebaceous hyperplasia or sebaceous gland adenomas. The malignant sebaceous gland carcinoma most commonly arises in the periocular area. Fewer than 120 cases of sebaceous cell carcinoma have been reported at extraocular sites. The most common site of origin is the meibomian glands of the eyelids, leading to the term meibomian gland carcinoma. However, this neoplasm can occur in other sebaceous glands, such as in the caruncle, the glands of Zeis, and in the eyebrow. Sebaceous cell carcinoma is a lethal eyelid malignancy and can masquerade as benign conditions. Error or delay in diagnosis is common, and this tumor carries a significant mortality rate with metastasis.


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A seizure happens because of abnormal electrical activity in the brain. It may go nearly unnoticed. Or, in some severe cases, it may cause unconsciousness and convulsions, when your body shakes uncontrollably. Seizures usually come on suddenly. How long and severe they are can vary. A seizure can happen to you just once, or over and over. If they keep coming back, that's epilepsy, or a seizure disorder. Less than one in 10 people who have a seizure get epilepsy.


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Nonsuicidal self-injury, often simply called self-injury, is the act of deliberately harming the surface of your own body, such as cutting or burning yourself. It's typically not meant as a suicide attempt. Rather, this type of self-injury is an unhealthy way to cope with emotional pain, intense anger and frustration. While self-injury may bring a momentary sense of calm and a release of tension, it's usually followed by guilt and shame and the return of painful emotions. Although life-threatening injuries are usually not intended, with self-injury comes the possibility of more serious and even fatal self-aggressive actions.


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A separated shoulder is an injury to the ligaments that hold your collarbone (clavicle) to your shoulder blade. In a mild separated shoulder, the ligaments might just be stretched. In severe injuries, ligaments might be torn. In most people, a separated shoulder doesn't usually require surgery. Instead, conservative treatment — such as rest, ice and pain relievers — is often enough to relieve the pain. Most people regain full shoulder function within a few weeks after having a separated shoulder.


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The colon is a long tube-like structure approximately 6 feet in length that stores and then eliminates waste material left over after digestion of food in the small intestine takes place. It is thought that pressure within the colon causes bulging pockets of tissue (sacs) that push out from the colonic walls as a person ages. A small bulging sac pushing outward from the colon wall is called a diverticulum. More than one bulging sac is referred to in the plural as diverticula. Diverticula can occur throughout the colon but are most common near the end of the left colon, referred to as the sigmoid colon, in Western countries. In Asia, the diverticula occur mostly on the right side of the colon. The condition of having these diverticula in the colon is called diverticulosis.


Diverticula are common in the Western world but are rare in areas such as Asia and Africa. Diverticula increase with age. They are uncommon before the age of 40, but are seen in more than 74% of people over the age of 80 years in the U.S. A person with diverticulosis usually has few or no symptoms. The most common symptoms associated with diverticulosis are abdominal pain, constipation, and diarrhea. In some of these patients the symptoms may be due to the concomitant presence of irritable bowel syndrome (IBS) or abnormalities in the function of the muscles of the sigmoid colon (in which case it is referred to as diverticular disease); simple diverticula should cause no symptoms. Occasionally, bleeding originates from a diverticulum, and it is referred to as diverticular bleeding.

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The sinus node is a specialized group of cells in the upper chamber of the heart, the right atrium, that creates electrical signals that regulate the pace and rhythm of the heartbeat. Normally, the sinus node produces a regular, steady pattern of signals. With SSS, the pattern is irregular. The normal heart beat should increase with activity and decrease with rest and sleep.  With SSS, this function is disrupted, with a heart beat that is too slow for the patient's level of activity.


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Your sinuses are air-filled spaces inside your forehead, cheekbones, and behind the bridge of your nose. When they get inflamed -- usually because of an allergic reaction or an infection -- they swell, make more mucus, and the channels that drain them can get blocked. The build-up of pressure in your sinuses causes pain that feels like a headache.


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Obstructive sleep apnea is a potentially serious sleep disorder. It causes breathing to repeatedly stop and start during sleep.There are several types of sleep apnea, but the most common is obstructive sleep apnea. This type of apnea occurs when your throat muscles intermittently relax and block your airway during sleep. A noticeable sign of obstructive sleep apnea is snoring. Treatments for obstructive sleep apnea are available. One treatment involves using a device that keep your airway open while you sleep. Another option is a mouthpiece to thrust your jaw forward during sleep. In more severe cases, surgery may be an option too


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Soft tissue sarcomas are a group of cancers that grow in parts of your body like your muscles, deep layers of skin, or in fat. They also can form on blood vessels, nerves, or connective tissues, which support organs and other kinds of tissues.Soft tissue sarcomas account for less than 1% of all cases of cancer. But there are dozens of different types, and they can happen in children and adults.About 12,000 people are diagnosed with one of these cancers every year.

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Solitary fibrous tumors are rare growths of soft tissue cells that can form nearly anywhere in the body.Solitary fibrous tumors most often occur in the lining around the outside of the lungs (pleural solitary fibrous tumors). Solitary fibrous tumors have also been found in the head and neck, breast, kidney, prostate, spinal cord, and other sites.Most solitary fibrous tumors are noncancerous (benign), but in rare cases, solitary fibrous tumors can be cancerous (malignant). Solitary fibrous tumors tend to grow slowly and may not cause signs and symptoms until they become very large.

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A fold of fat that some people have under their chin and that looks like a second chin

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A spinal cord injury is damage to the spinal cord. It’s an extremely serious type of physical trauma that’s likely to have a lasting and significant impact on most aspects of daily life.The spinal cord is a bundle of nerves and other tissue that the vertebrae of the spine contains and protects. The vertebrae are the bones stacked on top of each other that make up the spine. The spine contains many nerves, and extends from the brain’s base down the back, ending close to the buttocks.The spinal cord is responsible for sending messages from the brain to all parts of the body. It also sends messages from the body to the brain. We’re able to perceive pain and move our limbs because of messages sent through the spinal cord.If the spinal cord sustains an injury, some or all of these impulses may not be able to “get through.” The result is a complete or total loss of sensation and mobility below the injury. A spinal cord injury closer to the neck will typically cause paralysis throughout a larger part of the body than one in the lower back area.

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A spinal tumor is a growth that develops within your spinal canal or within the bones of your spine. A spinal cord tumor, also called an intradural tumor, is a spinal tumor that that begins within the spinal cord or the covering of the spinal cord (dura). A tumor that affects the bones of the spine (vertebrae) is called a vertebral tumor.Spinal cord tumors may be classified as one of three different types depending on where they occur relative to the protective membranes of the spinal cord.

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Stress fractures are tiny cracks in a bone. They're caused by repetitive force, often from overuse — such as repeatedly jumping up and down or running long distances. Stress fractures can also arise from normal use of a bone that's weakened by a condition such as osteoporosis.Stress fractures are most common in the weight-bearing bones of the lower leg and foot. Track and field athletes and military recruits who carry heavy packs over long distances are particularly susceptible, but anyone can have a stress fracture. If you start a new exercise program, for example, you might develop stress fractures if you do too much too soon.

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Stuttering affects the fluency of speech. It begins during childhood and, in some cases, lasts throughout life. The disorder is characterized by disruptions in the production of speech sounds, also called "disfluencies." Most people produce brief disfluencies from time to time. For instance, some words are repeated and others are preceded by "um" or "uh." Disfluencies are not necessarily a problem; however, they can impede communication when a person produces too many of them.In most cases, stuttering has an impact on at least some daily activities. The specific activities that a person finds challenging to perform vary across individuals. For some people, communication difficulties only happen during specific activities, for example, talking on the telephone or talking before large groups. For most others, however, communication difficulties occur across a number of activities at home, school, or work. Some people may limit their participation in certain activities. Such "participation restrictions" often occur because the person is concerned about how others might react to disfluent speech. Other people may try to hide their disfluent speech from others by rearranging the words in their sentence (circumlocution), pretending to forget what they wanted to say, or declining to speak. Other people may find that they are excluded from participating in certain activities because of stuttering. Clearly, the impact of stuttering on daily life can be affected by how the person and others react to the disorder.

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The subarachnoid space is the area between the brain and the skull. It is normally filled with cerebrospinal fluid (CSF), which acts as a floating cushion to protect the brain (see Anatomy of the Brain When blood is released into the subarachnoid space, it irritates the lining of the brain, increases pressure on the brain, and damages brain cells. At the same time, the area of brain that previously received oxygen-rich blood from the affected artery is now deprived of blood, resulting in a stroke. SAH is frequently a sign of a ruptured aneurysm


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Sudden Cardiac Arrest (SCA) occurs when the heart stops beating, abruptly and without warning. If this happens, blood stops flowing to the brain and other vital organs. In addition, if the heartbeat is not restored with an electrical shock immediately, death follows within minutes. SCA accounts for more than 350,000 deaths in the U.S. each year.SCA accounts for more than 350,000 deaths in the U.S. each year and is one of the leading causes of death in the United States each year. In fact, SCA claims one life every 90 seconds, taking more lives each year than breast cancer, lung cancer or AIDS. Unfortunately, 95 percent of people who experience SCA die as a result, mainly because treatment within minutes is not accessible.

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Sun allergy is a term often used to describe a number of conditions in which an itchy red rash occurs on skin that's been exposed to sunlight. The most common form of sun allergy is polymorphic light eruption, also known as sun poisoning.Some people have a hereditary type of sun allergy, while others develop signs and symptoms only when triggered by another factor — such as certain types of medications or skin exposure to plants such as limes or wild parsnip.Mild cases of sun allergy may resolve without treatment. More severe cases may require steroid creams or pills. People who have a severe sun allergy may need to take preventative measures and wear sun-protective clothing.

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An arrhythmia is an abnormality in the timing or pattern of the heartbeat. Arrhythmias may cause the heart to beat too rapidly, too slowly, or irregularly. They are common and may cause a wide variety of symptoms, such as a racing, skipping or fluttering sensation (called palpitations) in your chest.Cardiac arrhythmias also may cause light-headedness, fainting, chest pain, shortness of breath, fatigue or no symptoms at all. Many types of arrhythmia are merely nuisances, other types may be serious problems because they cause the patient to develop heart failure, pass out or even die suddenly when the heart beats too slowly or too rapidly to pump blood to the body.Supraventricular tachycardia is a series of rapid heartbeats that begin in or involve the upper chambers (atria) of the heart. SVT can cause the heart to beat very rapidly or erratically. As a result, the heart may beat inefficiently, and the body may receive an inadequate blood supply. There are three major types of SVT including:

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Tachycardia is a common type of heart rhythm disorder (arrhythmia) in which the heart beats faster than normal while at rest.It's normal for your heart rate to rise during exercise or as a physiological response to stress, trauma or illness (sinus tachycardia). But in tachycardia (tak-ih-KAHR-dee-uh), the heart beats faster than normal in the upper or lower chambers of the heart or both while at rest.Your heart rate is controlled by electrical signals sent across heart tissues. Tachycardia occurs when an abnormality in the heart produces rapid electrical signals that quicken the heart rate, which is normally about 60 to 100 beats a minute at rest.In some cases, tachycardia may cause no symptoms or complications. But if left untreated, tachycardia can disrupt normal heart function and lead to serious complications, including:


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Drug addiction is a chronic, often relapsing brain disease that causes compulsive drug seeking and use, despite harmful consequences to the drug addict and those around them. Drug addiction is a brain disease because the abuse of drugs leads to changes in the structure and function of the brain. Although it is true that for most people the initial decision to take drugs is voluntary, over time the changes in the brain caused by repeated drug abuse can impair a person's self-control and ability to make sound decisions, and at the same time create an intense impulse to take drugs.


It is because of these changes in the brain that it is so challenging for a person to stop abusing drugs. Fortunately, there are treatments that help people to counteract addiction's powerful disruptive effects and regain control of their lives. Research shows that combining addiction treatment medications, when appropriate, with behavioral therapy is the best way to ensure success for most patients. Treatment approaches that are tailored to each patient's drug abuse patterns and any concurrent medical, psychiatric, and social problems can help achieve  sustained recovery and a life without drugs.


As with other chronic diseases, such as diabetes, asthma, or heart disease, drug addiction can be managed effectively. Yet, it is not uncommon for a person to relapse and begin abusing drugs again. Relapse does not signal failure; rather, it indicates that treatment should be reinstated or adjusted, or that alternate treatment is needed to help the person regain control and recover.

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Takotsubo cardiomyopathy is a weakening of the left ventricle, the heart's main pumping chamber, usually as the result of severe emotional or physical stress, such as a sudden illness, the loss of a loved one, a serious accident, or a natural disaster such as an earthquake. (For additional examples, see "Stressors associated with takotsubo cardiomyopathy.") That's why the condition is also called stress-induced cardiomyopathy, or broken-heart syndrome. The main symptoms are chest pain and shortness of breath.

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The features of seizures beginning in the temporal lobe can be extremely varied, but certain patterns are common. There may be a mixture of different feelings, emotions, thoughts, and experiences, which may be familiar or completely foreign. In some cases, a series of old memories resurfaces. In others, the person may feel as if everything – including home and family – appears strange. Hallucinations of voices, music, people, smells, or tastes may occur. These features are called “auras” or “warnings.” They may last for just a few seconds or may continue as long as a minute or two.Experiences during temporal lobe seizures vary in intensity and quality. Sometimes the seizures are so mild that the person barely notices. In other cases, the person may be consumed with fright, intellectual fascination, or even pleasure.The experiences and sensations that accompany these seizures are often impossible to describe, even for the most eloquent adult. And of course it is even more difficult to get an accurate picture of what people are feeling.

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The temporomandibular joint (TMJ) is the joint that connects your mandible (lower jaw) to your skull. The joint can be found on both sides of your head in front of your ears. It allows your jaw to open and close, enabling you to speak and eat.This abbreviation is also used to refer to a group of health problems related to your jaw. These disorders can cause tenderness at the joint, facial pain, and difficulty moving the joint. According to the National Institute of Dental and Craniofacial Research, as many as 10 million Americans suffer from TMJ. TMJ is more common among women than men. These disorders are treatable, but there are many different possible causes. This can make diagnosis difficult.Keep reading to learn more about TMJ. You should discuss any concerns with your doctor.

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The cause of the majority of cases is the bell clapper deformity, an anatomic abnormality that is present in some males. This anatomical condition allows the spermatic cord to twist more easily, resulting in compromise of the blood supply to the testicle. This can occur spontaneously or may be associated with trauma. There is no way to detect this deformity. In significant number of men who have this anatomical abnormality will have it in both testicles.

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Tetanus is a serious bacterial infection that affects the nervous system and causes muscles throughout the body to tighten. It’s also called lockjaw because the infection often causes muscle contractions in the jaw and neck. However, it can eventually spread to other parts of the body.Tetanus infection can be life-threatening without treatment. Approximately 10 to 20 percent of tetanus infections are fatal, according to the Centers for Disease Control and Prevention (CDC).Tetanus is a medical emergency that requires immediate treatment in a hospital. Fortunately, tetanus is preventable through the use of a vaccine. However, this vaccine does not last forever. Tetanus booster shots are needed every 10 years to ensure immunity.Because of the easy availability of the vaccine, tetanus is rare in the United States. It’s more common in other countries that don’t yet have strong immunization programs.

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Dry mouth: The condition of not having enough saliva to keep the mouth wet. This is due to inadequate function of the salivary glands. Everyone has dry mouth once in a while when they are nervous, upset or under stress. But if someone has a dry mouth most all of the time, it can be uncomfortable and lead to serious health problems.
Dry mouth can cause difficulties in tasting, chewing, swallowing, and speaking. If it goes untreated, severe dry mouth can also lead to increased levels of tooth decay and infections of the mouth such as thrush. Severe dry mouth is not a normal part of aging. It can be a clue to systemic diseases such as Sjogren syndrome, systemic lupus erythematosus, rheumatoid arthritis, scleroderma, sarcoidosis, amyloidosis, and hypothyroidism. Some medications can also cause dry mouth.

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A thoracic aortic aneurysm is a weakened area in the upper part of the aorta. The aorta is the major blood vessel that feeds blood to the body.A thoracic aortic aneurysm may also be called thoracic aneurysm and aortic dissection (TAAD) because an aneurysm can lead to a tear in the artery wall (dissection) that can cause life-threatening bleeding. Small and slow-growing thoracic aortic aneurysms may not ever rupture, but large, fast-growing aneurysms may rupture.Depending on the size and growth rate of your thoracic aortic aneurysm, treatment may vary from watchful waiting to emergency surgery. Ideally, surgery for a thoracic aortic aneurysm can be planned if necessary.

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The term ‘thoracic outlet syndrome’ describes compression of the neurovascular structures as they exit through the thoracic outlet (cervicothoracobrachial region). The thoracic outlet is marked by the anterior scalene muscle anteriorly, the middle scalene posteriorly, and the first rib inferiorly. This condition has emerged as one of the most controversial topics in musculoskeletal medicine and rehabilitation [2]. This controversy extends to almost every aspect of the pathology including the definition, incidence, pathoanatomical contributions, diagnosis, and treatment.The term ‘TOS’ does not specify the structure being compressed. Investigators namely identify two main categories of TOS: the vascular form (arterial or venous), which raises few diagnostic problems, and the neurological form, which occurs in more than 95-99% of all cases of TOS. Therefore the syndrome should be differentiated by using the terms arterial TOS (ATOS), venous TOS (VTOS) or neurogenic 

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A joint is where bones connect and move.  Arthritis is thinning of the cartilage, which is the smooth covering of the joint.  The body reacts to loss of the joint surface by forming bone spurs (osteophytes) Thumb arthritis is a genetic predisposition: like graying and thinning of the hair, it comes with age and it shows up earlier in some families.  Unlike thinning of the hair, women tend to get thumb arthritis sooner than men do.


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A thunderclap headache is a severe headache that starts suddenly. This type of headache pain doesn’t gradually build in intensity. Instead, it’s an intense and very painful headache as soon as it starts. In fact, it’s frequently described as the worse headache of one’s life.A thunderclap headache may be a sign of a condition that can be life-threatening. It may be connected to some sort of bleeding in your brain. It’s important that you seek medical attention if you think you may be experiencing one. It may also have a benign cause that’s not life-threatening but should still be checked immediately to find out what’s causing it.


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There are two parts to your tongue: the oral tongue and the base of the tongue. Cancer can develop in either part.The oral tongue is the part you see when you poke your tongue out at someone. This is the front two thirds of your tongue. Cancers that develop in this part of the tongue come under a group of cancers called mouth (oral) cancer.The base of the tongue is the back third of the tongue. This part is very near your throat (pharynx). Cancers that develop in this part are called oropharyngeal cancers (pronounced oar-o-farin-gee-al

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Tuberous sclerosis complex (TSC) is a genetic disorder affecting cellular differentiation, proliferation, and migration early in development, resulting in a variety of hamartomatous lesions that may affect virtually every organ system of the body.The best-known cutaneous manifestation of TSC is adenoma sebaceum, which often does not appear until late childhood or early adolescence. This lesion is an angiofibroma (ie, cutaneous hamartoma) and is not related to excessive sebum or acne. Flat, reddish macular lesions develop first, which can be mistaken for freckles early on. See the image below.

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Turner syndrome is a chromosomal condition that affects development in females. The most common feature of Turner syndrome is short stature, which becomes evident by about age 5. An early loss of ovarian function (ovarian hypofunction or premature ovarian failure) is also very common. The ovaries develop normally at first, but egg cells (oocytes) usually die prematurely and most ovarian tissue degenerates before birth. Many affected girls do not undergo puberty unless they receive hormone therapy, and most are unable to conceive (infertile). A small percentage of females with Turner syndrome retain normal ovarian function through young adulthood.About 30 percent of females with Turner syndrome have extra folds of skin on the neck (webbed neck), a low hairline at the back of the neck, puffiness or swelling (lymphedema) of the hands and feet, skeletal abnormalities, or kidney problems. One third to one half of individuals with Turner syndrome are born with a heart defect, such as a narrowing of the large artery leaving the heart (coarctation of the aorta) or abnormalities of the valve that connects the aorta with the heart (the aortic valve). Complications associated with these heart defects can be life-threatening.Most girls and women with Turner syndrome have normal intelligence. Developmental delays, nonverbal learning disabilities, and behavioral problems are possible, although these characteristics vary among affected individuals.


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Tricuspid valve disease affects the valve that connects the upper and lower chambers (atrium and ventricle) on the right side of your heart.Aurora Health Care’s teams are the region’s leaders in diagnosing and treating heart valve diseases. We offer customized treatment using the most advanced, minimally invasive procedures, whether the condition is congenital (a birth defect) or develops later in life.

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Trichotillomania (trik-o-til-o-MAY-nee-uh), also called hair-pulling disorder, is a mental disorder that involves recurrent, irresistible urges to pull out hair from your scalp, eyebrows or other areas of your body, despite trying to stop.Hair pulling from the scalp often leaves patchy bald spots, which causes significant distress and can interfere with social or work functioning. People with trichotillomania may go to great lengths to disguise the loss of hair.For some people, trichotillomania may be mild and generally manageable. For others, the compulsive urge to pull hair is overwhelming. Some treatment options have helped many people reduce their hair pulling or stop entirely.

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Tricuspid atresia is a condition seen in newborns in which they’re born without an important part of the heart called “the tricuspid valve.” This valve plays a part in the heart’s essential function, which is to pump blood between the lungs and body.In some newborns, the tricuspid valve is missing or hasn’t properly developed. Tricuspid atresia is a rare heart disorder that’s congenital, or present at birth. It’s a serious condition, and it can be life-threatening.

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Traumatic brain injury (TBI) is a complex injury with a broad spectrum of symptoms and disabilities. The impact on a person and his or her family can be devastating. The purpose of this site is to educate and empower caregivers and survivors of traumatic brain injuries. This site aims to ease the transition from shock and despair at the time of a brain injury to coping and problem solving. Bookmark this site for the latest medical breakthroughs and brain research, the highest quality treatment for brain damage, the symptoms of brain injuries and the nation's best traumatic brain injury rehabilitation centers and resource information.


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Tourette syndrome (TS) is a neurological disorder characterized by repetitive, stereotyped, involuntary movements and vocalizations called tics. The disorder is named for Dr. Georges Gilles de la Tourette, the pioneering French neurologist who in 1885 first described the condition in an 86-year-old French noblewoman.The early symptoms of TS are typically noticed first in childhood, with the average onset between the ages of 3 and 9 years. TS occurs in people from all ethnic groups; males are affected about three to four times more often than females. It is estimated that 200,000 Americans have the most severe form of TS, and as many as one in 100 exhibit milder and less complex symptoms such as chronic motor or vocal tics. Although TS can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst tic symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood.


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Uterine fibroids are benign tumors that originate in the uterus (womb). Although they are composed of the same smooth muscle fibers as the uterine wall (myometrium), they are much denser than normal myometrium. Uterine fibroids are usually round.Uterine fibroids are often described based upon their location within the uterus. Subserosal fibroids are located beneath the serosa (the lining membrane on the outside of the uterus). These often appear localized on the outside surface of the uterus or may be attached to the outside surface by a pedicle. Submucosal (submucous) fibroids are located inside the uterine cavity beneath the inner lining of the uterus. Intramural fibroids are located within the muscular wall of the uterus.

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Uterine polyps are soft red outgrowths from the lining of the womb (the endometrium), usually less than 1 cm in diameter, which often flatten to fit the cavity of the uterus.The stalk of the polyp (or pedicle) is usually short, but sometimes it grows long enough for the polyp to project from the cervix (the lower opening of the womb). Polyps are prone to bleeding, and a uterine polyp that develops near the fallopian tubes may obstruct the opening of the tubes, possibly leading to difficulty with becoming pregnant. Uterine polyps can develop in pre- or post-menopausal women. Very rarely, polyps can be cancerous.


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The uterus (the womb, in which a fetus develops) is normally held in place inside the pelvis with various muscles and ligaments. Sometimes, because of childbirth or difficult labor and vaginal delivery, these tissues are weakened. As a woman ages and with age-related decrease in the concentration of the hormone estrogen, her uterus can move downward into the vaginal canal, causing the condition known as a prolapsed uterus.Muscle weakness or relaxation may allow the uterus to sag or come completely out of the body. Prolapsed uterus can be described in the following stages

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Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation. Currently, the most widely used first-line treatment options for this malignancy are resection, radiation therapy, and enucleation. There are two main types of radiation therapy: plaque brachytherapy (iodine-125, ruthenium-106, or palladium-103, or cobalt-60) and teletherapy (proton beam, helium ion, or stereotactic radiosurgery using cyber knife, gamma knife, or linear accelerator). The alternative to radiation is enucleation. Although these therapies achieve satisfactory local disease control, long-term survival rate for patients with uveal melanoma remains guarded, with risk for liver metastasis. There have been advances in early diagnosis over the past few years, and with the hope survival rates could improve as smaller tumors are treated. As in many other cancer indications, both early detection and early treatment could be critical for a positive long-term survival outcome in uveal melanoma. These observations call attention to an unmet medical need for the early treatment of small melanocytic lesions or small melanomas in the eye to achieve local disease control and vision preservation with the possibility to prevent metastases and improve overall patient survival.

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A urinary tract infection (UTI) is an infection in any part of your urinary system — your kidneys, ureters, bladder and urethra. Most infections involve the lower urinary tract — the bladder and the urethra.Women are at greater risk of developing a UTI than are men. Infection limited to your bladder can be painful and annoying. However, serious consequences can occur if a UTI spreads to your kidneys.Doctors typically treat urinary tract infections with antibiotics. But you can take steps to reduce your chances of getting a UTI in the first place

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An umbilical hernia creates a soft swelling or bulge near the navel (umbilicus). If your baby has an umbilical hernia, you may notice the bulge only when he or she cries, coughs or strains. The bulge may disappear when your baby is calm or lies on his or her back.Umbilical hernias in children are usually painless. Umbilical hernias that appear during adulthood may cause abdominal discomfort.

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Puffiness under the eyes can be bothersome, but it’s usually just a cosmetic concern. While rare, undereye puffiness can be a symptom of some kidney and thyroid conditions. If you occasionally wake up with puffiness under the eyes, consider what you did the day before to look for lifestyle causes such as staying up late or eating too much salt. Consider talking to your doctor about possible treatments for chronic undereye puffiness.

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Unstable angina belongs to the spectrum of clinical presentations referred to collectively as acute coronary syndromes (ACSs), which also includes ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI). [1, 2] Unstable angina is considered to be an ACS in which there is myocardial ischemia without detectable myocardial necrosis (ie, cardiac biomarkers of myocardial necrosis —such as creatine kinase MB isozyme, troponin, myoglobin—are not released into the circulation). See the image below.

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Cancer of the ureter (ureteral cancer) is a type of cancer that begins in the cells that line the inside of the tubes (ureters) that connect your kidneys to your bladder. Ureters are part of the urinary tract, and they carry urine produced by the kidneys to the bladder.Ureteral cancer is uncommon. It occurs most often in older adults and in people who have previously been treated for bladder cancer.Ureteral cancer is closely related to bladder cancer. The cells that line the ureters are the same type of cells that line the inside of the bladder. People diagnosed with ureteral cancer have a greatly increased risk of bladder cancer, so your doctor will recommend tests to look for signs of bladder cancer.Treatment for ureteral cancer typically involves surgery. In certain cases, chemotherapy may be recommended.

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Ureteral obstructions are blockages in your urinary tract, which includes your kidneys, bladder, the tubes that carry urine from your kidneys to your bladder (ureters), and the tube that connects your bladder to the outside of your body (urethra). Blockages can develop for many reasons, including gastrointestinal problems. Ureteral obstructions are more common in men, especially as they get older and their prostate gland enlarges.Obstructions can be cured with surgery, but they need to be treated promptly. If they’re not, they can lead to severe illness, kidney damage and life-threatening infections.

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The idea behind functional training is that each exercise should be more natural and carry over into daily life. Functional training exercises tend to activate more muscles and therefore consume more energy. These multidimensional exercises also tend to improve your natural movement skills and enhance your general mobility.See how many of the below functional training exercises you can incorporate into your workouts for a more practical and fat burning workout.


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Zumba is an exercise fitness program created by Colombian dancer and cyclist/choreographer Alberto "Beto" "Power Pedal" Perez during the 1990s.[1] Zumba is a trademark owned by Zumba Fitness, LLC. The Brazilian pop singer Claudia Leitte has become the international ambassador to Zumba Fitness. Zumba involves dance and aerobic movements performed to energetic music. The choreography incorporates hip-hop, soca, samba, salsa, merengue and mambo. Squats and lunges are also included.[3] Zumba Fitness, the owner of the Zumba program, does not charge licensing fees to gyms or fitness centers.[4] Approximately 15 million people take weekly Zumba classes in over 200,000 locations across 180 countries


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Those who are looking to feel the burn, baby! Looking to strengthen and tone your legs and glutes? Step right up.We combine the awesome toning and strengthening power of Step aerobics, with the fun fitness-party that only Zumba® brings to the dance-floor.Zumba® Step increase cardio and calorie burning, while adding moves that define and sculpt your core and legs.


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This beginner level workout features basic choreography. Gin Miller, the inventor of step aerobics, leads this video. In an article appearing on the IDEA Health and Fitness Association website, Miller says "Everbody Steps" is a top seller. It's a solid, complete introduction to step workouts. You burn fat while learning the step basics from Miller, an IDEA Instructor of the Year with 12 years of step experience. Miller makes the moves understandable and explains common step-aerobic terminology in laymen's terms. The video has six distinct segments that allow you to advance at your own pace and stop when you want. The workout begins with the simplest steps and the easiest patterns and progresses into classic step-aerobic combinations, such as straddles, turns and transitions.


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Look around. There are countless articles in magazines and online about gaining size and strength. Everyone wants to get strong, and everyone wants to add muscle, but most don’t achieve the goal. Why? A number of reasons, including ridiculous exercise selection, poor programming, and—from what I’ve seen as a coach for almost 25 years—bad form.If you’re willing to do the hard work and make the commitment to using perfect form, I’ve got the ultimate plan for you: an eight-week guide to getting stronger than you ever thought you could.It’s a simple plan based on compound movements, high-repetition heavy lifting, and maximum-effort training. Throw in the right assistance work and you’ve got a plan for success.


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At the foundation of fusion yoga is a community of people coming together to practice yoga as a way to be free of pain, to think more clearly, and to have a better relationship with the world.  Fusion yoga is a supporting, exciting, and empowering experience for yoga practitioners of every level. Whether you're new or highly experienced, you'll find a class offering that meets your needs.  Our yoga classes are meant to challenge you mentally and physically.  All classes ask you to look within- to tap into your own innate needs, potential and expression as you cultivate your own experience.


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Gym workouts can help you burn calories and lose fat, gain strength, tone muscle groups and develop an overall sense of well-being. To add a twist to your regular workout routine, get together with one or more others at your gym and play a few gym workout games. Be sure all game participants stay hydrated before, during and after the workout. Consult your physician before beginning an exercise program.


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A nine-to-five job shackled to your cubicle leaves you with hardly any stamina to hit the gym in the evenings. Add to that, lack of motivation and it can only spell doom for your waistline. In such a scenario, can a party workout be that much-needed boost The party workout is redefining the concept of the workout, which brings the dance club into the gym. Fitness clubs host disco-lit classes of boot-camp style routines set to pumping music played by DJs. It's the latest fitness fad hitting New York gyms, and is generally wrapped up with post-workout 'pretend'tinis made from vitamin water! While it sounds like the perfect fix for those who want a club experience minus the calories of cocktails, can it really work for you? We get experts to comment.


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 Inactivity is taking its toll on human beings. As fitness professionals, we are keenly aware that society is fascinated with the human body—with losing fat, specifically—and yet, getting people to exercise is still a major obstacle. Obesity, a significant and growing health problem, has been associated with heart disease, diabetes, hyperlipidemia, hypertension and hyperinsulinemia, among other conditions. The numbers speak louder than words. Overweight is defined as having a body mass index (BMI) of 25 to 29.9, obesity as having a BMI equal to or greater than 30. Fifty-five to 60 percent of adults over the age of 18 have a BMI of at least 25; approximately 22 percent have a BMI of 30 or higher (Jakicic et al. 2001).


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An echocardiogram (echo) is a graphic outline of the heart's movement. During an echo test, ultrasound (high-frequency sound waves) from a hand-held wand placed on your chest provides pictures of the heart's valves and chambers and helps the sonographer evaluate the pumping action of the heart. Echo is often combined with Doppler ultrasound and color Doppler to evaluate blood flow across the heart's valves.

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This test is the same as a treadmill exercise test. This test checks the function of the heart during and after physical activity. In addition, an IV will be started and, at the peak of exercise, the patient will be injected with a mild isotope. The patient will then be escorted to the scanning room adjacent to the stress lab for approximately 30 minutes. From there, the patient will be free to leave and will return 3 hours later for a repeat scan.


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A brainstem auditory evoked response (BAER) test measures how your brain processes the sounds you hear. The BAER test records your brainwaves in response to clicks or other audio tones that are played for you. The test is also called a brainstem auditory evoked potentials (BAEP) or auditory brainstem response (ABR) test.


A BAER test can help to diagnose hearing loss and nervous system disorders, especially in newborns, young children, and others who may not be able to participate in a standard hearing test.


BAER tests are often administered to canines and are the only scientifically reliable way to test a dog’s ability to hear with one or both ears.

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We reviewed the records of 52 amyotrophic lateral sclerosis (ALS) patients examined between 1995 and 2000 who had needle electromyography (EMG) of their respiratory muscles, including the diaphragm, at or near the time of their diagnosis. With respiratory function testing, patients with abnormal diaphragmatic EMG at diagnosis (Group 1, n=23) had significantly lower forced vital capacity (FVC), lower daytime arterial PO(2) and higher PCO(2) measurements (p<0.05) than patients with normal diaphragmatic EMG (Group 2, n=29). Twenty-eight percent of the patients without symptoms or signs of respiratory insufficiency at the time they were examined had an abnormal diaphragm EMG. Mean survival of Groups 1 and 2 were similar. However, sub-analysis of patients within each group, comparing those treated with non-invasive positive pressure ventilation (NIPPV) with those not treated, showed that treated patients in Group 1 (abnormal diaphragm EMG) survived significantly longer (p<0.05) than untreated patients. They also started NIPPV earlier than treated patients in Group 2. We conclude that respiratory muscle EMG was simply and safely performed on ALS patients at or around the time of diagnosis. The procedure can detect sub-clinical respiratory muscle dysfunction. The technique used for EMG of the respiratory muscles, its pitfalls and contraindications are also reviewed.

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This course shows you videos of the commonly studied muscles in the upper extremity, insertional activity and muscle activation and motor unit analysis techniques to help you gain a working understanding of the technical skills you need to perform needle EMG examinations. The video will focus on muscle localization and needle insertion techniques, what results you should expect, how to study the shape, amplitude and duration of motor unit waveforms, pitfalls and common errors you should watch for. Muscles studied include the First Dorsal Interosseous (FDI), the Abductor Pollicis Brevis (APB), the Flexor Carpi Radialis (FCR) the Brachio-Radialis (BR), the Triceps (TRI), the Deltoid (DEL) and the Cervical Paraspinals.

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A nerve conduction study (NCS) involves activating nerves electrically with small safe pulses over several points on the skin, usually on the limbs, and measuring the responses obtained. Usually, the response or signal is measured from the nerve itself or from a muscle supplied by the nerve being activated. This gives information about the state of health of the nerve, muscle and neuromuscular junction (the portion responsible for communication between the nerve and muscle). A commercial device is normally employed to measure the signals.

Electromyography (also known as needle EMG) involves the measuring of electrical activity within muscles by way of a needle electrode. It is rather similar to having an electrical microphone at the tip of the needle. Muscles are electrically active organs, and the signals and patterns of signals can lend additional information regarding the state of the muscle as well as the nerve supplying it.

In Australia, the person responsible for these tests is a neurologist, who frequently has had further training in the subspecialty of clinical neurophysiology.
A doctor may recommend that you undergo this test. There are a wide variety of conditions that are assessed with this technique. Quite frequently, the examination is requested because the patient is experiencing symptoms that suggest some problem with the nerves (numbness, tingling, weakness or pain) or muscles (weakness or pain), even though the physical examination is normal. Indeed, in many cases, there is no abnormality seen and the test can then be reassuring, but it cannot detect all conditions. In general terms, the test is useful for detecting if there is a significant abnormality, but this is also often easier when there is a definite clinical abnormality. In such cases, the test can help clarify what the problem is, although usually, unless the nerve problem is a common entrapment (site of compression), other tests may be required to ascertain the exact nature of the problem.
There are several types of nerves but generally speaking, the two major types are motor and sensory nerves. Motor nerves carry signals from the brain to the muscle to enable contraction and movement, and sensory nerves relay information to the brain. When the nerve is stimulated with metal electrodes (metallic patch/es that can conduct signals), a response can be measured by surface (on the skin) electrodes some distance away in sensory nerves overlying the nerve itself. For the motor nerves, the response is usually detected over the muscle that is activated by that nerve. In this fashion, results can reveal information about the size and speed of the electrically conducted impulse. The size usually reveals the number of nerve fibres present and the speed, the integrity of the myelin (insulating membrane around the nerve ‘axon’ or cable). This is why the word ‘conduction’ is used.
You will be given instructions on how to prepare for the test. You should not use creams or emollients on your hands and feet (the most common sites of your nerve tests) on the day of the test, and preferably since your last shower or bath. Generally speaking, there are no other preparations of note.

Please advise the neurologist performing the test if you have a pacemaker or other similar devices. If you are taking warfarin, heparin or some other medication to thin your blood, and if you are having a needle EMG test, you should advise both your GP and the neurologist. A measurement of how thin your blood is may be important before that test can be performed.
The NCS procedure is usually very safe and is non-invasive. Firstly, you will be told how to position yourself and the skin area will be prepared. Then some electrodes will be attached to your skin and you will be forewarned when to expect the stimulation. Many people are understandably anxious about the intensities of the small safe electrical pulses that are passed via the skin, but usually relax quickly when they know what to expect. It is faily important that you remain relaxed for the recordings to minimise the ‘noise’ (interference) in the recordings from excessive muscular activity.
Here, a small needle is inserted through the skin into a muscle belly. Sterilisation of the skin and a local anaesthetic is not generally required. Usually the consultation and procedure takes about 30-45 minutes in all. More complicated assessments may demand more time.
Following the test, you will be allowed to put on your garments and shoes. It should be noted that the final interpretation of the clinical meaning of the test rests with the clinician who ordered the test. This is because they can put together the whole picture. For this reason, the neurologist performing the test can only give you limited information about the meaning of the results, and may not even be able to provide any information on the next step or any possible treatments because they are unaware of all the other clinical information.


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Proximal conduction studies by F-wave technique, with conventional distal motor and sensory conduction were performed along the ulnar nerves of 20 patients each with cervical spondylotic radiculopathy and/or myelopathy and with classical motor neurone disease (MND). Such F-wave parameters as shortest F-latency, F-conduction velocity, conduction time and F-ratio were calculated. Twenty-five age- and sex-matched healthy volunteers acted as controls. Proximal slowing associated with sensory conduction abnormalities and normal distal motor conduction favored cervical spondylosis (CS). Distal slowing with a normal proximal motor and sensory conduction was associated with motor neurone disease.


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Somatosensory Evoked Potentials (SSEPs) are electrical responses recorded from the nervous system following electrical stimulation of a peripheral nerve.  For example, stimulation of the median nerve at the wrist produces electrical activity that travels along the sensory pathway on its way to the brain. This activity can be recorded with electrodes positioned along that pathway.


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Visual Evoked Potential/ Response (VEP/VER) measures the electrical signal generated at visual cortex in response to visual stimulation. The visual cortex is primarily activated by the central visual field and there is a large presentation of the macula at occipital cortex. VEP depends on integrity of visual pathway including eye, optic nerve, chiasma, optic tract, optic radiation and cerebral cortex. Standard International Society for Clinical Electrophysiology of Vision (ISCEV) protocols[1] assess the anterior visual pathway (eye, optic nerve anterior to the optic chiasma). For dysfunctions of posterior visual pathway extended multi-channel protocols are needed.


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A barium enema is a type of X-ray imaging test that allows doctors to examine your lower intestinal tract. It involves delivering a contrast solution that contains the metallic element barium into your rectum while a technician takes X-ray images of the area. The barium solution will be delivered using an enema — a process in which your doctor pushes a liquid into your rectum through your anus.


The barium solution helps to improve the quality of the X-ray images by highlighting certain areas of tissue. The X-ray used in this procedure is known as fluoroscopy. It allows the radiologist to see your internal organs in motion by tracking the flow of the barium solution through your intestinal tract.


The test doesn’t require painkillers or sedation, but there may be moments of slight discomfort.

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Barium tests are used to help see the outline of the upper parts of the gut (gastrointestinal tract) such as the gullet (oesophagus), stomach and upper gut (small intestines). The gut (gastrointestinal tract) does not show up very well on ordinary X-ray pictures. However, if you drink a white liquid that contains a chemical called barium sulfate, the outline of the upper parts of the gut (oesophagus, stomach and small intestines) shows up clearly on X-ray pictures. This is because X-rays do not pass through barium.

Depending on what part of your gut is being looked at, you may have one or more of the tests listed below. In each test, the barium coats the lining of the gut being tested. Therefore, abnormalities in the lining or structure of the gut can be seen on the X-ray pictures. In each of the following tests, several X-ray pictures are taken using low-dose X-rays. The total amount of radiation for each test is quite small and thought to be safe. The X-ray machine is usually linked to a TV monitor. Still pictures, or a video recording of X-ray pictures taken in quick succession, can be taken if necessary.

In this test you drink some barium liquid. The barium liquid is often fruit-flavoured so it is pleasant to drink. You stand in front of an X-ray machine whilst X-ray pictures are taken as you swallow. This test aims to look for problems in the gullet (oesophagus). These include a narrowing (stricture), hiatus hernias, tumours, reflux from the stomach, disorders of swallowing, etc. You will usually be asked not to eat or drink for a few hours before this test. A barium swallow test takes about 10 minutes.

This is similar to a barium swallow (above). However, it aims to look for problems in the stomach and the first part of the gut (small intestine), known as the duodenum. These problems may include ulcers, small fleshy lumps (polyps), tumours, etc. You drink some barium liquid but you then lie on a couch whilst X-ray pictures are taken over your tummy (abdomen). It may take a little longer to do than a barium swallow.

So that the barium coats all around the lining of the stomach, the doctor doing the test (radiologist) may do one or more of the following:

Ask you to swallow some bicarbonate powder and citric acid before swallowing the barium. These 'fizz up' when they mix in the stomach and make some gas. (You may have to resist the urge to burp.) The gas expands the stomach and duodenum and also pushes the barium to coat the lining of the stomach and duodenum. This makes the X-ray pictures much clearer. It is the shape and contours of the lining of the stomach and duodenum which need to be seen most clearly on the pictures.

Ask you to turn over on to your stomach on the couch. Various X-ray pictures may be taken whilst you are in different positions. You may be given an injection of a drug that makes the muscles in the stomach and gut relax.You will usually be asked not to eat anything for several hours before this test. (Food particles in the gut can make it difficult to interpret the X-rays.) However, you may be allowed sips of water up to two hours before the test.


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A barium meal is a diagnostic test used to detect abnormalities of the esophagus, stomach and small bowel using X-ray imaging. X-rays can only highlight bone and other radio-opaque tissues and would not usually enable visualization of soft tissue. However, infusion of the contrast medium barium sulfate, a radioopaque salt, coats the lining of the digestive tract, allowing accurate X-ray imaging of this part of the abdomen.

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Have your dinners planned for the week within seconds!  As a Scramble member, each week you receive a suggested meal plan with:


Five family-friendly dinners complete with main course and one to two easy, healthy side dishes

Meals feature seasonal fruits and vegetables for great flavors and savings

All meals have full nutritional information by meal and by individual dish

An organized shopping list with items listed by grocery store section


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A barium swallow is an imaging test that uses X-rays to look at your upper gastrointestinal (GI) tract. Your upper GI tract includes the back of your mouth and throat (pharynx) and your esophagus.


You may have just a barium swallow. Or this test may be done as part of an upper GI series. This series looks at your esophagus, stomach, and the first part of the small intestine (duodenum).


X-rays use a small amount of radiation to create images of your bones and internal organs. X-rays are most often used to find bone or joint problems, or to check the heart and lungs. A barium swallow is one type of X-ray.


Fluoroscopy is often used during a barium swallow. Fluoroscopy is a kind of X-ray “movie.”


The test also uses barium. Barium is a substance that makes certain area of the body show up more clearly on an X-ray. The radiologist will be able to see size and shape of the pharynx and esophagus. He or she will also be able see how you swallow. These details might not be seen on a standard X-ray. Barium is used only for imaging tests for the GI tract.

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A carotid Doppler test is generally an outpatient procedure, states Johns Hopkins Medicine. During the test, the patient must lie on his back with his neck bent back slightly. A technician applies a gel to the skin, presses a device called a transducer against the neck, and moves it around the area of the carotid artery. The technician then repeats the process on the other side of the neck. Carotid Doppler tests do not expose patients to radiation, and they usually do not cause any discomfort.


Patients who have carotid artery blockage or narrowing sometimes experience symptoms such as dizziness, confusion, drowsiness or headache that prompt a doctor to perform a carotid Doppler test, states Johns Hopkins Medicine. Other symptoms that may indicate problems with blood flow in the carotid arteries include momentary blindness in one eye or temporary problems speaking or moving. Carotid Doppler is sometimes performed as part of an evaluation prior to major cardiac surgery.

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A Doppler ultrasound is a noninvasive test that can be used to estimate the blood flow through your blood vessels by bouncing high-frequency sound waves (ultrasound) off circulating red blood cells. A regular ultrasound uses sound waves to produce images, but can't show blood flow.


A Doppler ultrasound may help diagnose many conditions, including:


Blood clots

Poorly functioning valves in your leg veins, which can cause blood or other fluids to pool in your legs (venous insufficiency)

Heart valve defects and congenital heart disease

A blocked artery (arterial occlusion)

Decreased blood circulation into your legs (peripheral artery disease)

Bulging arteries (aneurysms)

Narrowing of an artery, such as in your neck (carotid artery stenosis)

A Doppler ultrasound can estimate how fast blood flows by measuring the rate of change in its pitch (frequency). During a Doppler ultrasound, a technician trained in ultrasound imaging (sonographer) presses a small hand-held device (transducer), about the size of a bar of soap, against your skin over the area of your body being examined, moving from one area to another as necessary.


This test may be done as an alternative to more-invasive procedures, such as angiography, which involves injecting dye into the blood vessels so that they show up clearly on X-ray images.


A Doppler ultrasound test may also help your doctor check for injuries to your arteries or to monitor certain treatments to your veins and arteries.

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Alterations of the abdominal aorta are relatively common, particularly in older people. Technological advances in the fields of ultrasonography, computed tomography, angiography, and magnetic resonance imaging have greatly increased the imaging options for the assessment of these lesions. Because it can be done rapidly and is also non-invasive, ultrasonography plays a major role in the exploration of the abdominal aorta, from its emergence from the diaphragm to its bifurcation. It is indicated for the diagnosis and follow-up of various aortic diseases, especially aneurysms. It can be used to define the shape, size, and location of these lesions, the absence or presence of thrombi and their characteristics. It is also useful for monitoring the evolution of the lesion and for postoperative follow-up. However, its value is limited in surgical planning and in emergency situations.

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This study aimed to evaluate the vascular pattern of solid breast lesions using power Doppler ultrasonography (PDUS) and assess whether the presence of intratumoural penetrating vessels can predict breast cancer malignancy.

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Carotid ultrasound uses sound waves to produce pictures of the carotid arteries in the neck which carry blood from the heart to the brain. A Doppler ultrasound study – a technique that evaluates blood flow through a blood vessel – is usually part of this exam. It’s most frequently used to screen patients for blockage or narrowing of the carotid arteries, a condition called stenosis which may increase the risk of stroke.


Little or no special preparation is required for this procedure. Leave jewelry at home and wear loose, comfortable clothing. A loose-fitting, open necked shirt or blouse is ideal.

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The use of Doppler ultrasound to assess both the changing haemodynamics of the neonatal circulation and the perfusion of the brain is reviewed. The brain is particularly susceptible to both ischaemic and haemorrhagic injury in preterm and asphyxiated infants. However, the unique characteristics of the transitional neonatal circulation, and of the cerebral vasculature, pose considerable problems in the interpretation of Doppler signals from intracranial arteries. A volumetric Doppler method which eliminates some of those problems is discussed. The same method allows full assessment of the cardiovascular status of the newborn infant, including estimation of ductal shunting and left ventricular output. Doppler ultrasound, if used with a full understanding of the inherant assumptions and limitations of the particular methodology, is likely to prove invaluable in investigating pathological cerebral and cardiac vascular events in the newborn.

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With the most advanced Echo-cardiography ultrasound and color Doppler system from Philips which uses a X- Matrix Probe (>9000 piezoelectric crystals) and break-through pure wave single crystal technology deliver high wualty images.


This is the only diagnostic centre in city doing ultrasound contrast study. 

Some of the features are unique in the machine and not available elsewhere. The machine gives extreme resolution for excellent 2D and LIVE 3D (4D) images. It has extreme color sensitivity. 3D images in cross sectional view (all three planes). VOCAL ( Volumetric organ calculation), Multislice CT like images. PANORAMIC images to include a wide area in single image. Dynamic MR to give maximum resolution, Broad band frequency compounding, harmonic imaging etc.

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A recent estimate of the number of men in the United States suffering with complete erectile dysfunction is 10 to 20 million. When partial erectile dysfunction is included, the estimate jumps to 30 million.1 Age-specific prevalence is estimated to be 5% at age 40, increasing to 15% to 25% by age 65. In clinical series, the ratio of organic to psychologic male sexual dysfunction also varies with age: 70% of patients under 35 years of age have a psychogenic cause, and 85% of patients over 50 years of age have organic impotence.2 Patient accounts of coital frequency similarly vary with age: 75% of men in their seventh decade report having coitus once monthly, and 37% of patients 60 to 69 years old describe having weekly coitus.

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Doppler ultrasonography of the lower extremity arteries is a valuable technique, although it is less frequently indicated for peripheral arterial disease than for deep vein thrombosis or varicose veins. Ultrasonography can diagnose stenosis through the direct visualization of plaques and through the analysis of the Doppler waveforms in stenotic and poststenotic arteries. To perform Doppler ultrasonography of the lower extremity arteries, the operator should be familiar with the arterial anatomy of the lower extremities, basic scanning techniques, and the parameters used in color and pulsed-wave Doppler ultrasonography.

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A Doppler ultrasound is a test that uses high-frequency sound waves to measure the amount of blood flow through your arteries and veins, usually those that supply blood to your arms and legs.


Vascular flow studies, also known as blood flow studies, can detect abnormal flow within an artery or blood vessel. This can help to diagnose and treat a variety of conditions, including blood clots and poor circulation. A Doppler ultrasound can be used as part of a blood flow study.


A Doppler ultrasound is a risk-free and pain-free procedure that requires little preparation. The test provides your doctor with important information about the flow of blood through your major arteries and veins. It can also reveal blocked or reduced blood flow through narrowed areas in the arteries, which could eventually lead to a stroke.

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A Doppler ultrasound, also called a Color Doppler test is a non-invasive test that can be used to estimate your blood flow through blood vessels. It helps doctors evaluate blood flow through major arteries and veins, such as those of the arms, legs, and neck. It can show blocked or reduced flow of blood through narrow areas in the major arteries of the neck that could cause a stroke. It also can reveal blood clots in leg veins (deep vein thrombosis, or DVT) that could break loose and block blood flow to the lungs (pulmonary embolism). During pregnancy, Doppler ultrasound may be used to look at blood flow in an unborn baby (foetus) to check the health of the foetus. 

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A prospective study comparing colour Doppler ultrasound (US) with the 'gold standard' of intra-arterial digital subtraction angiography in the evaluation of renal transplant artery stenosis was performed. Both the intrarenal vessels and the transplant renal artery were examined by Doppler US. Diagnostic arteriography was performed only if, on Doppler, the peak systolic velocity in the transplant renal artery exceeded 1.5 ms-1. Of 109 patients, the transplant artery could not be visualized using colour Doppler US in three, and these were omitted from statistical analysis. Of the remaining 106 patients, 31 had a peak systolic velocity greater than 1.5 ms-1 in the transplant renal artery and were referred for DSA. Of the multiple renal Doppler indices recorded, the peak systolic velocity in the transplant artery was the best discriminating measurement for the detection of renal artery stenosis. A peak systolic velocity of > or = 2.5 ms-1 in the transplant renal artery had a sensitivity of 100% and a specificity of 95% for the detection of renal artery stenosis ( > 50% diameter reduction). Although a significant difference in Pulsatility Index, Resistive Index, Acceleration Index and Acceleration Time was recorded from the intrarenal vessels in the angiographically normal and stenosed groups with Doppler, these measurements were less useful as discriminating diagnostic tests. In conclusion, the peak systolic velocity in the transplant renal artery is the most sensitive Doppler criterion for renal artery stenosis and is sensitive and specific enough to be used as a screening test. The intrarenal acceleration time and index should not be used in isolation.

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A device called a transducer is passed over the scrotum, directing high-frequency sound waves (ultrasound) at the structures within, including the testicle, epididymis (the tube that transports sperm from the testicle), and blood vessels. The sound waves are reflected back to the transducer and electronically converted into real-time images displayed on a viewing monitor. These images are then saved on film or video and reviewed for abnormalities.

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Color Doppler is an ultrasound-based diagnostic imaging technique used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs for possible Pathology or Lesions. Colour Doppler is also used for the following applications:-

Carotid Colour Doppler to detect risk of stroke and paralysis by   evaluating the vessels   in the neck that supply blood to the brain.  Peripherial Arterial Colour Doppler.

Peripherial Venous Colour Doppler for detection of Deep Vein Thrombosis (DVT).

Renal Doppler (especially for hypertensive patients and diabetics).

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Color Doppler ultrasound is a medical imaging technique which is used to provide visualization of the bloodflow, using color processing to add color to the image so that a doctor or care provider can clearly see what is happening inside the body. This technique requires the use of an ultrasound machine which is capable of color Doppler ultrasound, and can be performed in a hospital or clinic as an outpatient procedure. Having this imaging study performed is not usually painful, and the patient does not require sedatives. 

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Venous ultrasound uses sound waves to produce images of the veins in the body. It is commonly used to search for blood clots, especially in the veins of the leg – a condition often referred to as deep vein thrombosis. Ultrasound does not use ionizing radiation and has no known harmful effects.


On occasion, you may be asked not to eat or drink anything but water for six to eight hours beforehand. Otherwise, little or no special preparation is required for this procedure. Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown.

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A Doppler ultrasound, also called a Color Doppler test is a non-invasive test that can be used to estimate your blood flow through blood vessels. It helps doctors evaluate blood flow through major arteries and veins, such as those of the arms, legs, and neck. It can show blocked or reduced flow of blood through narrow areas in the major arteries of the neck that could cause a stroke. It also can reveal blood clots in leg veins (deep vein thrombosis, or DVT) that could break loose and block blood flow to the lungs (pulmonary embolism). During pregnancy, Doppler ultrasound may be used to look at blood flow in an unborn baby (foetus) to check the health of the foetus.

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The first reported case of the use of computed tomography (CT) to guide biopsy was published in 1975 (1). By 1976, CT was heralded as the single most accurate method for guiding biopsy (2). With the increasing availability of CT and the development of percutaneous techniques, this statement has proved true: CT is now the imaging modality of choice for guiding percutaneous procedures. Over the following 20 years, CT-guided procedures were performed by obtaining a planning image of the region of interest and using cutaneous markers to specify a percutaneous access point. Needle advancement was documented by leaving the scanning room and obtaining one to three contiguous images at the level of the needle plane and repeating the process with each subsequent manipulation of the needle. The advent of CT fluoroscopy in the early 1990s allowed the needle to be visualized in real time, expediting the procedure and markedly reducing its overall length, partly because participants did not leave the scanning room (3). However, the use of real-time CT fluoroscopy potentially increased patient radiation dose and, for the first time, exposed physicians, nurses, and technologists to radiation.


Because CT fluoroscopy–guided procedures have become more common, they account for an important portion of the radiation dose delivered to our patient population. It has been shown that radiation dose may be significantly reduced in diagnostic CT examinations with no loss of diagnostic image quality (4). Likewise, dose should be taken into account when planning interventional procedures, and the radiation dose used should be as low as reasonably achievable to complete the procedure successfully. In this article, we discuss how patient dose is estimated and how knowledge of how a radiation dose is distributed over the course of a procedure is essential in developing low-dose protocols. If certain straightforward steps are followed, it is possible to significantly reduce radiation exposure for both patients and physicians

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Computed tomography, more commonly known as a CT or CAT scan, is a diagnostic medical test that, like traditional x-rays, produces multiple images or pictures of the inside of the body.


The cross-sectional images generated during a CT scan can be reformatted in multiple planes, and can even generate three-dimensional images. These images can be viewed on a computer monitor, printed on film or transferred to a CD or DVD.


CT images of internal organs, bones, soft tissue and blood vessels provide greater detail than traditional x-rays, particularly of soft tissues and blood vessels.


A cardiac CT scan for coronary calcium is a non-invasive way of obtaining information about the presence, location and extent of calcified plaque in the coronary arteries—the vessels that supply oxygen-containing blood to the heart muscle. Calcified plaque results when there is a build-up of fat and other substances under the inner layer of the artery. This material can calcify which signals the presence of atherosclerosis, a disease of the vessel wall, also called coronary artery disease (CAD). People with this disease have an increased risk for heart attacks. In addition, over time, progression of plaque build up (CAD) can narrow the arteries or even close off blood flow to the heart. The result may be chest pain, sometimes called "angina," or a heart attack.


Because calcium is a marker of CAD, the amount of calcium detected on a cardiac CT scan is a helpful prognostic tool. The findings on cardiac CT are expressed as a calcium score. Another name for this test is coronary artery calcium scoring.

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Triphasic spiral liver Computed Tomography (CT) is a standardized procedure for the detection and characterization of a large variety of benign and malignant liver lesions. This helps in the decline of mortality and morbidity rates among patients with liver disease. Spiral computed tomography has gained acceptance as the preferred computed tomography technique for routine liver evaluation because it provides image acquisition at peak enhancement of liver parenchyma during a single breath hold. In addition fast data acquisition allows successive scanning of the entire liver at different intervals after injection of the iodinated contrast material, thus creating the possibility of multiphase liver computed tomography.

Triphasic CT scan is a good non-invasive tool and can be used as first line imaging modality for differentiating benign and malignant focal liver lesions. Benign lesions like haemangioma can be reliably differentiated from malignant liver lesion; therefore unnecessary biopsies can be avoided. It is also particularly useful for hypervascular lesions which can be easily missed on routine CT scanning.



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A doctor or physician may order a CT scan of the leg to make detailed pictures and analyze the internal structure. Computerized tomography (CT) scanning is useful to get a very detailed 3D image of certain parts of legs.


The process begins by taking many different X-ray views at various different angles, which are then combined with the use of computer processing to create cross-sectional images of the bones and soft tissue inside of your body, including tissues inside of solid organ. Ordinary X-ray testing does not show clear images of soft tissue, so doctors often request CT scanning to get a good image of soft tissue including organs, muscles, blood vessels, nerves, and the brain. Sometimes a contrast dye is used as it shows up clearer on the screen.


A quality CT scan of the leg will use multiple x-rays to make cross sectional pictures of the leg.

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A CT scan, commonly referred to as a CAT scan, is a type of X-ray that produces cross-sectional images of a specific part of the body. In the case of a lumbar spine CT scan, your doctor can see a cross-section of your lower back. The scanning machine circles the body and sends images to a computer monitor, where they are reviewed by a technician.


The lumbar portion of the spine is a common area where back problems occur. The lumbar spine is the lowest portion of your spine. It’s made up of five vertebral bones. Below the lumbar spine is the sacrum and below the sacrum is the coccyx (tailbone). Large blood vessels, nerves, tendons, ligaments, and cartilage are also part of the lumbar spine.

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CT scanning-sometimes called CAT scanning-is a noninvasive medical test that helps physicians diagnose and treat medical conditions.


CT scanning combines special x-ray equipment with sophisticated computers to produce multiple images or pictures of the inside of the body. These cross-sectional images of the area being studied can then be examined on a computer monitor, printed or transferred to a CD.


CT scans of internal organs, bones, soft tissue and blood vessels provide greater clarity and reveal more details than regular x-ray exams.


Using specialized equipment and expertise to create and interpret CT scans of the body, radiologists can more easily diagnose problems such as cancers, cardiovascular disease, infectious disease, appendicitis, trauma and musculoskeletal disorders.

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Computed tomography (CT) perfusion of the head uses special x-ray equipment to show which areas of the brain are adequately supplied with blood (perfused) and provides detailed information about blood flow to the brain. CT perfusion is fast, painless, noninvasive and accurate. It’s a useful technique for measuring blood flow to the brain, which may be important for treating stroke, brain blood vessel disease and brain tumors.

Computed tomography (CT) perfusion imaging shows which areas of the brain are adequately supplied or perfused with blood and provides detailed information on delivery of blood or blood flow to the brain.

CT perfusion scanning is a noninvasive medical test that helps physicians diagnose and treat medical conditions.

CT scanning combines special x-ray equipment with sophisticated computers to produce multiple images or pictures of the inside of the body. These cross-sectional images of the area being studied can then be examined on a computer monitor, printed or transferred to a CD.

CT scans of internal organs, bones, soft tissue and blood vessels provide greater clarity and reveal more details than regular x-ray exams.

In many ways CT scanning works very much like other x-ray examinations. Different body parts absorb the x-rays in varying degrees. It is this crucial difference in absorption that allows the body parts to be distinguished from one another on an x-ray film or CT electronic image.

In a conventional x-ray exam, a small amount of radiation is aimed at and passes through the part of the body being examined, recording an image on a special electronic image recording plate. Bones appear white on the x-ray; soft tissue, such as organs like the heart or liver, shows up in shades of gray, and air appears black.With CT scanning, numerous x-ray beams and a set of electronic x-ray detectors rotate around you, measuring the amount of radiation being absorbed throughout your body. Sometimes, the examination table will move during the scan, so that the x-ray beam follows a spiral path. A special computer program processes this large volume of data to create two-dimensional cross-sectional images of your body, which are then displayed on a monitor. CT imaging is sometimes compared to looking into a loaf of bread by cutting the loaf into thin slices. When the image slices are reassembled by computer software, the result is a very detailed multidimensional view of the body's interior.

Refinements in detector technology allow nearly all CT scanners to obtain multiple slices in a single rotation. These scanners, called multislice CT or multidetector CT, allow thinner slices to be obtained in a shorter period of time, resulting in more detail and additional view capabilities.


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Abdominal and Pelvic CT scan shows the abdominal and pelvic organs of our body (such as the pancreas, liver, kidneys, spleen, and adrenal glands) and the gastrointestinal tract. A doctor usually orders this test to check for a cause of abnormal pain and sometimes to follow-up on an abnormality seen on another test such as an ultrasound.

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A fistulogram is a special x-ray procedure. It uses a form of real-time x-ray called fluoroscopy and a barium-based contrast material to produce images of an abnormal passage within the body called a fistula. It looks at the blood flow in your fistula or graft (dialysis access). This procedure can check to see if it is blocked or if there is any narrowing (stenosis).

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Fluoroscopy is a study of moving body structures. It’s much like an X-ray "movie" and is often done while a contrast dye moves through the part of the body being examined. A continuous X-ray beam is passed through the body part and sent to a video monitor so that the body part and its motion can be seen in detail. Fluoroscopy, as an imaging tool, allows healthcare providers to look at many body systems, including the skeletal, digestive, urinary, cardiovascular, respiratory, and reproductive systems.


Fluoroscopy may be used to evaluate specific areas of the body. These include the bones, bowel, muscles, heart vessels, and joints.

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A micturating cysto-urethrogram (or MCU) is a study using X-rays that shows the bladder and urethra (the tube that carries urine from the bladder and out of the body) while passing urine (see children’s X-ray examination). The test is performed to find out if the urine goes from the bladder back up to the kidneys instead of out through the urethra, known as vesico-ureteric reflux (VUR). This can be the cause of recurrent urinary tract (in the bladder or kidneys) infection and kidney damage. The test also shows how the bladder empties and what the urethra looks like.This test is most commonly performed on children under six months of age, but can be used less commonly as an investigation for older children and adults with multiple recurrent urinary tract infections.


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Diffusion tensor imaging tractography, or DTI tractography, is an MRI (magnetic resonance imaging) technique that measures the rate of water diffusion between cells to understand and create a map of the body’s internal structures; it is most commonly used to provide imaging of the brain. This advanced imaging technique, which provides much more detailed images of the brain than a conventional MRI, may also be used in the diagnosis of stroke, acute ischemia, brain tumors and multiple sclerosis, as well as pre-operative planning.  Using MRI technology, DTI tractography is non-invasive and uses radio waves and a magnetic field to produce images of the brain, tissues and skull. MRI technology provides detailed images showing small changes in body tissue and blood flow, which makes it an extremely reliable tool for the detection of disease, injury, bleeding and swelling.  Loyola offers state-of-the-art imaging and diagnostic techniques in order to provide timely and accurate diagnosis for our patients. Our expert radiologists are recognized nationally for clinical excellence, innovative diagnostic and therapeutic methods and skilled use of the latest technology. Our experienced technologists provide testing in a caring and compassionate environment where we want you to feel comfortable asking any questions you may have about your test or procedure. 


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Magnetic Resonance Imaging is a highly advanced imaging modality. Epilepsy Protocol MRI involves obtaining images of brain slices through MRI scanning in epileptic patients. This scanning enables the doctor in obtaining evidences of abnormalities or injuries in brain. Underlying pathologies inside of brain like infections or tumors cannot be seen externally. Such occurrences can be investigated through an MRI Epilepsy Protocol. As a result, MRI becomes the most accurate mode for planning line of treatment.


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CSF flow studies are performed using a variety of MRI techniques and are able to qualitatively assess and quantify pulsatile CSF flow. The most common technique used is time resolved 2D phase contrast MRI with velocity encoding. Note, when referring to CSF flow in the setting on imaging we are referring to pulsatile to-and-fro flow due to vascular pulsations rather than bulk transport of CSF (the mechanism by which produced CSF is absorbed, via absorption at arachnoid granulations and via the glymphatic pathway). The latter is too slow to be easily assessed clinically. 


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The anatomy of the craniovertebral junction, although complex, may be well visualized by routine MR imaging. This essay discusses the anatomy of the complex articulations of the craniovertebral junction. Representative MR images and gross anatomic photographs are presented to illustrate the intricate ligamentous and articular anatomy. Knowledge of the normal anatomy of the occipitoatlantoaxial region is necessary in order to understand the common disorders that affect this area. The most common disorders are trauma and arthropathies, but also include congenital abnormalities and neoplasm. The resultant abnormal mechanics may lead to neurologic sequelae or pain

 

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Erectile dysfunction is a common health condition affecting millions of men worldwide. It shadows their self-confidence and intimate lives. Such a condition can impact your personal life as it snatches away the excitement of getting intimate with your partner. Therefore, understanding all symptoms along with the erectile dysfunction causes is vital for a fulfilling sexual life. This article is a comprehensive guide to determining early signs of erectile dysfunction and treatments for ED. We will also discuss some major causes and treatments of this condition.

What is Erectile Dysfunction?

ED is a medical condition. Here, a man cannot achieve and maintain an erection which is necessary for satisfactory sexual performance. The major causes of this condition are:


People suffering from physiological conditions also get ED treatment. If you are making bad lifestyle choices like excessive alcohol consumption and no exercise, it also contributes to this condition. 


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 An MRI scan uses magnets and radio waves to capture images inside your body without making a surgical incision. The scan allows your doctor to see the soft tissue of your body, like muscles and organs, in addition to your bones. An MRI can be performed on any part of your body. A lumbar MRI specifically examines the lumbar section of your spine — the region where back problems commonly originate.The lumbosacral spine is made up of the five lumbar vertebral bones (L1 thru L5), the sacrum (the bony “shield” at the bottom of your spine), and the coccyx (tailbone). The lumbosacral spine also consists of large blood vessels, nerves, tendons, ligaments, and cartilage.


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Pituitary gland plays a central role in body growth, metabolism, and reproductive function. A number of diseases that affect the pituitary-hypothalamic axis can have profound clinical, endocrinological as well as neurological consequences. These conditions can be classified as neoplastic, infectious, inflammatory, posttraumatic, congenital/developmental, and physiological. Various neoplastic conditions include pituitary adenoma/apoplexy, hypothalamic glioma, craniopharyngioma, rathke cleft cyst, germinoma, teratoma, metastasis, leukemic infiltration, lymphoma, and Langerhans cell histiocytosis. Infectious and inflammatory causes include tubercular/lymphocytic hypophysitis, sarcoidosis, and Wegener's granulomatosis. Traumatic causes include postoperative sella or transection of the pituitary stalk. Accurate diagnostic differentiation of these lesions is essential for both safe and effective disease management. Recent advances in neuroimaging helps the radiologists and endocrinologists to study the pituitary region in greater detail. Magnetic resonance imaging (MRI) is the imaging modality of choice for evaluating hypothalamic-pituitary-related endocrine diseases.

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Erectile dysfunction (ED) is the inability to get or keep an erection firm enough to have sexual intercourse. It’s also sometimes referred to as impotence.


Occasional ED isn’t uncommon. Many men experience it during times of stress. Frequent ED can be a sign of health problems that need treatment. It can also be a sign of emotional or relationship difficulties that may need to be addressed by a professional.


Not all male sexual problems are caused by ED. Other types of male sexual dysfunction include:

premature ejaculation

delayed or absent ejaculation

lack of interest in sex

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Magnetic resonance imaging (MRI) of the shoulder uses a powerful magnetic field, radio waves and a computer to produce detailed pictures of the bones, tendons, muscles and blood vessels within the shoulder joint. It is primarily used to assess injuries. Tell your doctor about any health problems, recent surgeries or allergies and whether there’s a possibility you are pregnant. The magnetic field is not harmful, but it may cause some medical devices to malfunction. Most orthopedic implants pose no risk, but you should always tell the technologist if you have any devices or metal in your body. Guidelines about eating and drinking before your exam vary between facilities. Unless you are told otherwise, take your regular medications as usual. Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown. If you have claustrophobia or anxiety, you may want to ask your doctor for a mild sedative prior to the exam.


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Temporomandibular joint (TMJ) dysfunction is a common condition that is best evaluated with magnetic resonance (MR) imaging. The first step in MR imaging of the TMJ is to evaluate the articular disk, or meniscus, in terms of its morphologic features and its location relative to the condyle in both closed- and open-mouth positions. Disk location is of prime importance because the presence of a displaced disk is a critical sign of TMJ dysfunction. However, disk displacement is also frequently seen in asymptomatic volunteers, so that other findings may be required to help make the diagnosis. These findings include thickening of an attachment of the lateral pterygoid muscle, rupture of retrodiskal layers, and joint effusion and can serve as indirect early signs of TMJ dysfunction. It is important for the radiologist to detect early MR imaging signs of dysfunction, thereby avoiding the evolution of this condition to its final stage, an advanced and irreversible phase that is characterized by osteoarthritic changes such as condylar flattening or osteophytes. Further studies conducted with the latest MR imaging techniques will allow a better understanding of the sources of TMJ pain and of any discrepancy between imaging findings and patient symptoms.


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The purpose of this study was to correlate disc position and the type of disc displacement, intra-capsular effusion and degenerative changes of the condyle as demonstrated in MRI studies. In this study, 126 temporomandibular joints (TMJs) of 63 patients with TMJ disorders were investigated using clinical examination and MRI. One hundred and twelve TMJs were found to have internal derangement as disc displacement. The angle between the posterior margin of the disc and the vertical line drawn through the centre of the condyle was measured on MRI for each TMJ. The positions of the discs were normal, 0 degrees-10 degrees, in 11.11%; slightly displaced, 11 degrees-30 degrees, in 37.30%; mildly displaced 31 degrees-50 degrees, in 15.08%; moderately displaced, 51 degrees-80 degrees, in 7.14% of the TMJs with anterior displacement with reduction (ADDR). The disc position was severely displaced anteriorly, as over 80 degrees, in all TMJs with anterior disc displacement without reduction (ADD), constituting 27.78% of all cases. We found that the smaller the degree of disc displacement the milder the internal derangement and that the intra-capsular effusion was more frequently associated with TMJ with ADDR. The degenerative condylar changes were more severe with an increased degree of anterior disc displacement.


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Magnetic resonance cholangiopancreatography (MRCP) is a special type of magnetic resonance imaging (MRI) exam that produces detailed images of the hepatobiliary and pancreatic systems, including the liver, gallbladder, bile ducts, pancreas and pancreatic duct. Magnetic resonance imaging (MRI) is a non-invasive medical test that physicians use to diagnose and treat medical conditions.MRI uses a powerful magnetic field, radio frequency pulses and a computer to produce detailed pictures of organs, soft tissues, bone and virtually all other internal body structures. MRI does not use ionizing radiation (x-rays). Detailed MR images allow physicians to evaluate various parts of the body and determine the presence of certain diseases.

Doctors use MRCP to examine diseases of the liver, gallbladder, bile ducts, pancreas and pancreatic duct. These may include tumours, stones, inflammation or infection evaluate patients with pancreatitis to detect the underlying cause. In patients with pancreatitis, an MRCP may be performed using a medication called Secretin to assess for long term scarring and to determine the amount of healthy pancreatic function and secretions help to diagnose unexplained abdominal pain and provide a less invasive alternative to endoscopic retrograde cholangiopancreatography (ERCP). ERCP is a diagnostic procedure that combines endoscopy, which uses an illuminated optical instrument to examine inside the body, with iodinated contrast injection and x-ray images. You may be asked to wear a gown during the exam or you may be allowed to wear your own clothing if it is loose-fitting and has no metal fasteners. Guidelines about eating and drinking before an MRI exam vary. Usually, you will be instructed not to eat or drink anything for several hours before your procedure.Jewellery and other accessories should be left at home if possible, or removed prior to the MRI scan. Because they can interfere with the magnetic field of the MRI unit, metal and electronic items are not allowed in the exam room. In general, metal objects used in orthopaedic surgery pose no risk during MRI. However, a recently placed artificial joint may require the use of another imaging procedure. If there is any question of their presence, an x-ray may be taken to detect and identify any metal objects.


You will usually be alone in the exam room during the MRI procedure. However, the technologist will be able to see, hear and speak with you at all times using a two-way intercom. Many MRI centres allow a friend or parent to stay in the room as long as they are also screened for safety in the magnetic environment.  A radiologist, a physician specifically trained to supervise and interpret radiology examinations, will analyze the images and send a signed report to your primary care or referring physician, who will share the results with you.


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Pulmonary function tests are a broad range of tests that measure how well the lungs take in and exhale air and how efficiently they transfer oxygen into the blood. Spirometry measures how well the lungs exhale. The information gathered during this test is useful in diagnosing certain types of lung disorders, but is most useful when assessing for obstructive lung diseases (especially asthma and chronic obstructive pulmonary disease, COPD). Lung volume measurement detects restrictive lung diseases. In this set of diseases, a person cannot inhale a normal volume of air. Restrictive lung diseases may be caused by inflammation or scarring of the lung tissue (interstitial lung disease) or by abnormalities of the muscles or skeleton of the chest wall. Testing the diffusion capacity (also called the DLCO) permits an estimate of how efficiently the lungs transfer oxygen from the air into the bloodstream.


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A retrograde urethrogram is a routine radiologic procedure (most typically in males) used to image the integrity of the urethra. Hence a retrograde urethrogram is essential for diagnosis of urethral injury, or urethral stricture. The procedure involves the insertion of a Foley catheter into the distal urethra and minimally inflating it. This is followed by instillation of 30mL of water-soluble contrast and a plain radiograph is obtained; leakage of the contrast suggests urethral injury (usually secondary to pelvic trauma) and is an indication for surgical intervention.It is used when there is suspicion of urethral trauma, such as a history of trauma to the area followed by pain, inability to void urine, or the presence of blood at the urethral meatus, a scrotal hematoma, or free-floating prostate on rectal examination. If a urethral injury is suspected, a retrograde urethrogram should be performed before attempting to place a Foley catheter into the bladder. If there is a urethral disruption, a suprapubic catheter should be placed.

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Ultrasound imaging also called as sonography uses a transducer or probe to generate sound waves and produce pictures of the body's internal structures. It is often used to help diagnose unexplained pain, swelling or infection. It is used to see internal body structures such as tendons, muscles, joints, vessels and internal organs. It may also be used to provide imaging guidance to needle biopsies or to see and evaluate conditions related to blood flow. It is also the preferred imaging method for monitoring a pregnant woman and her unborn child. It does not use ionizing radiation, has no known harmful effects, and provides a clear picture of soft tissues that don't show up well on x-ray images.Most of these level II ultrasounds should be done in the second trimester of pregnancy usually between 18 and 22 weeks. It uses sound waves to produce pictures of a baby (embryo or fetus) within a pregnant woman, as well as the mother's uterus and ovaries. It does not use ionizing radiation, has no known harmful effects, and is the preferred method for monitoring pregnant women and their unborn babies. A Doppler ultrasound study – a technique that evaluates blood flow in the umbilical cord, fetus or placenta – may be part of this exam. It is a totally painless and safe procedure. It is useful test to establish the presence of fetus, estimate the age of pregnancy, diagnose congenital abnormalities of the fetus, assess fetal growth and well being etc. Preparation - No special preparation is needed.


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Your doctor has requested an ultrasound-guided biopsy. The goal of a biopsy is to remove a sample of tissue for testing in a laboratory. A biopsy can help diagnose abnormalities such as infection, inflammation or malignancy. During your biopsy, an imaging physician will use an ultrasound scanner to accurately guide a needle to the site of the biopsy. The needle will then be used to remove a tissue sample. At the S. Mark Taper Foundation Imaging Center, a highly trained medical team will oversee your procedure. This team will include an imaging physician, a diagnostic medical sonographer and a registered nurse.


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An ultrasound / SONOGRAPHY is a procedure that uses high-frequency sound waves to scan a the internal organs of the body woman’s abdomen and pelvic cavity, the reproductive system and the fetus of a pregnant woman creating a picture (sonogram) of the baby and placenta. Although the terms ultrasound and sonogram are technically different, they are used interchangeably and reference the same exam. They can show the structure and movement of the body's internal organs, including the abdomen, the fetus of pregnant women as well as blood flowing through blood vessels.

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A biophysical profile (BPP) test measures the health of your baby (fetus) during pregnancy. A BPP test may include a non stress test with electronic fetal heart monitoring and a fetal ultrasound. The BPP measures your baby's heart rate, muscle tone, movement, breathing, and the amount of amniotic fluid around your baby. A BPP is commonly done in the last trimester of pregnancy. If there is a chance that your baby may have problems during your pregnancy (high-risk pregnancy), a BPP may be done by 32 to 34 weeks or earlier. Some women with high-risk pregnancies may have a BPP test every week or twice a week in the third trimester. It is usually done to keep track of your baby’s health. 

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A breast ultrasound uses sound waves to make a picture of the tissues inside the breast. A breast ultrasound can show all areas of the breast, including the area closest to the chest wall, which is hard to study with a mammogram. Breast ultrasound does not use X-rays or other potentially harmful types of radiation. A breast ultrasound is used to see whether a breast lump is filled with fluid (a cyst) or if it is a solid lump. An ultrasound does not replace the need for a mammogram, but it is often used to check abnormal results from a mammogram


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Ultrasound imaging of the breast uses sound waves to produce pictures of the internal structures of the breast. It’s primarily used to help diagnose breast lumps or other abnormalities your doctor may have found during a physical exam, mammogram or breast MRI. Ultrasound is safe, noninvasive and does not use ionizing radiation.This procedure requires little to no special preparation. Leave jewelry at home and wear loose, comfortable clothing. You will be asked to undress from the waist up and to wear a gown during the procedure.

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 Ultrasound imaging of the head uses sound waves to produce pictures of the brain and cerebrospinal fluid. It is most commonly performed on infants, whose skulls have not completely formed. A transcranial Doppler ultrasound evaluates blood flow in the brain’s major arteries. Ultrasound is safe, noninvasive, and does not use ionizing radiation.This procedure requires little to no special preparation. Your doctor will instruct you on how to prepare, including whether adults undergoing the exam should refrain from using nicotine-based products that may cause blood vessels to constrict. Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown.

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 B-scan ultrasonography is an important adjuvant for the clinical assessment of various ocular and orbital diseases. With understanding of the indications for ultrasonography and proper examination technique, one can gather a vast amount of information not possible with clinical examination alone. This article is designed to describe the principles, techniques, and indications for echographic examination, as well as to provide a general understanding of echographic characteristics of various ocular pathologies. 

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USG scan for Follicular Monitoring is done to study ovarian follicles that are used to identify ovulation of egg. For couples planning for pregnancy, ovulation period is the important period to try on, for conception to happen. Out of many ways available, the most reliable way to understand the ovulation is Follicular monitoring. It’s an endovaginal scan carried to study the ovaries, uterus and uterus lining. Looking at ovaries, the growth of follicles inside ovaries can be assessed giving a chance to predict the ovulation and also look if the womb is getting ready for pregnancy.

With follicular monitoring, you will get to know the growth of follicles, the approximate rupture period of follicles and hence can predict the ovulation period thereby have an intercourse happen at the right time for conception to take place. The womb if not yet ready for pregnancy can be treated by some supplements prescribed by the doctors.

This scan is carried out in a slightly dark examination room. You will have to undress down from your waist while you get covered by a sheet. Now you will be asked to position yourself lying down on your back on a special bed with your knees bent. Once you position yourself comfortably; the transducer, a sterile lubricated covered electronic device, is gently inserted into your vagina to look at the uterus and ovaries. Depending on how relaxed the patient is, the test takes up to 15 minutes.


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 X-ray beams are passed through the abdomen, producing images of the kidneys, ureters, and bladder on a special type of film. KUB radiography is often used as a first step in diagnosing problems of the urinary system, and is usually done in conjunction with intravenous pyelography.

 

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An ultrasound / SONOGRAPHY is a procedure that uses high-frequency sound waves to scan a the internal organs of the body woman’s abdomen and pelvic cavity, the reproductive system and the fetus of a pregnant woman creating a picture (sonogram) of the baby and placenta. Although the terms ultrasound and sonogram are technically different, they are used interchangeably and reference the same exam. They can show the structure and movement of the body's internal organs, including the abdomen, the fetus of pregnant women as well as blood flowing through blood vessels.

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Thyroid ultrasound uses sound waves to produce pictures of the thyroid gland within the neck. It does not use ionizing radiation and is commonly used to evaluate lumps or nodules found during a routine physical or other imaging exam.This procedure requires little to no special preparation. Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown.

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Ultrasound  is safe and paUltrasoundinless, and produces pictures of the inside of the body using sound waves. Ultrasound imaging, also called ultrasound scanning or sonography, involves the use of a small transducer (probe) and ultrasound gel placed directly on the skin. High-frequency sound waves are transmitted from the probe through the gel into the body. The transducer collects the sounds that bounce back and a computer then uses those sound waves to create an image. Ultrasound examinations do not use ionizing radiation (as used in x-rays), thus there is no radiation exposure to the patient. Because ultrasound images are captured in real-time, they can show the structure and movement of the body's internal organs, as well as blood flowing through blood vessels.


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Ultrasound is a high-frequency sound that you cannot hear but it travels through fluid and soft tissues. However, it bounces back, or echoes, when it hits a more solid, dense surface such as a valve or bile in the gallbladder etc. So, when ultrasound 'hits' structures of different densities in our bodies, it echoes differently with each hit. 


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Ultrasound imaging of the scrotum uses sound waves to produce pictures of a man’s testicles and surrounding tissues. It is the primary method used to help evaluate disorders of the testicles, epididymis (a tube immediately next to a testicle that collects sperm) and scrotum. Ultrasound is safe, noninvasive, and does not use ionizing radiation.

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An ultrasound / SONOGRAPHY is a procedure that uses high-frequency sound waves to scan a the internal organs of the body woman’s abdomen and pelvic cavity, the reproductive system and the fetus of a pregnant woman creating a picture (sonogram) of the baby and placenta. Although the terms ultrasound and sonogram are technically different, they are used interchangeably and reference the same exam. They can show the structure and movement of the body's internal organs, including the abdomen, the fetus of pregnant women as well as blood flowing through blood vessels





 

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Thyroid ultrasound uses sound waves to produce pictures of the thyroid gland within the neck. It does not use ionizing radiation and is commonly used to evaluate lumps or nodules found during a routine physical or other imaging exam.This procedure requires little to no special preparation. Leave jewelry at home and wear loose, comfortable clothing. You may be asked to wear a gown.

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A transrectal ultrasound (TRUS) may also be called prostate sonogram or endorectal ultrasound. It is used to look at the prostate and tissues around it. An ultrasound transducer (also called a probe) sends sound waves through the wall of the rectum and into the prostate and surrounding tissue. A computer analyzes the wave patterns (called echoes) as they bounce off the organs and converts them into an image that doctors view on a video screen.

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An ultrasound test uses high-frequency sound waves to create images of your internal organs. Imaging tests can identify abnormalities and help doctors diagnose conditions. A transvaginal ultrasound, also called an endovaginal ultrasound, is a type of pelvic ultrasound used by doctors to examine female reproductive organs. This includes the uterus, fallopian tubes, ovaries, cervix, and vagina.

“Transvaginal” means “through the vagina.” This is an internal examination. Unlike a regular abdominal or pelvic ultrasound, where the ultrasound wand, or transducer, rests on the outside of the pelvis, this procedure involves your doctor or a technician inserting an ultrasound probe about two or three inches into your vaginal canal.


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An ultrasound / SONOGRAPHY is a procedure that uses high-frequency sound waves to scan a the internal organs of the body woman’s abdomen and pelvic cavity, the reproductive system and the fetus of a pregnant woman creating a picture (sonogram) of the baby and placenta. Although the terms ultrasound and sonogram are technically different, they are used interchangeably and reference the same exam. They can show the structure and movement of the body's internal organs, including the abdomen, the fetus of pregnant women as well as blood flowing through blood vessels.


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Ultrasound imaging also called as sonography uses a transducer or a probe to generate sound waves and produce pictures of the body's internal structures. It is often used to help diagnose unexplained pain, swelling or infection. It is also used to see internal body structures such as tendons, muscles, joints, vessels and internal organs. Ultrasound abdomen is primarily used for evaluating the kidneys, liver, pancreas, gall bladder etc.It may also be used to provide imaging guidance to needle biopsies or to see and evaluate conditions related to blood flow. It does not use ionizing radiation, has no known harmful effects, and provides a clear picture of soft tissues that don't show up well on x-ray images. It is a painless, safe and non invasive procedure.
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17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other hormones released by the adrenal glands in males and females, and by the testes in males.

A 24-hour urine sample is needed. You will need to collect your urine over 24 hours. Your health care provider will tell you how to do this. Follow instructions exactly to ensure accurate results.

Your provider will ask you to temporarily stop any medicines that may affect the test results. Be sure to tell your provider about all the medicines you take. These include:

1.Antibiotics

2.Aspirin (if you are on long-term aspirin)

3.Birth control pills

4.Diuretics (water pills)

5.Estrogen..


Increased levels of 17-ketosteroids may be due to:

1.Adrenal gland problems such as tumor, Cushing syndrome

2.Imbalance of sex hormones in females (polycystic ovary syndrome)

3.Ovarian cancer

4.Testicular cancer


Decreased levels of 17-ketosteroids may be due to:

1.Adrenal glands not making enough of their hormones (Addison disease)

2.Kidney damage

3.Pituitary gland not making enough of its hormones (hypopituitarism)

4.Removal of the testicles (castration)

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There are different types of cortisol tests that may be performed, including blood, saliva, and urine tests. The urine test is done over a period of 24 hours.

The cortisol urine test tends to be more comprehensive than the other types of cortisol tests. It measures the total amount of cortisol excreted into the urine over a 24-hour period. Blood tests or saliva tests, however, only measure cortisol levels at a particular time of day. Some people also find blood tests to be stressful, and since the body releases more cortisol during times of stress, the results may not be as precise. In some cases, your doctor may order both a cortisol urine test and another type of cortisol test to obtain more accurate results.


Cushing’s syndrome is a collection of symptoms associated with high cortisol levels. The most common symptoms include:


1.Increased urination

2.Increased thirst

3.Fatty tissue deposits, especially in the midsection and upper back

4.Pink or purple stretch marks on the skin

5.Weight gain

6.Fatigue

7.Muscle weakness

8.Thinning skin that bruises easily

9.Women may have irregular periods and excess facial and chest hair. Children may show delayed physical or cognitive development.


The symptoms of low cortisol levels often emerge slowly. At first, they may only appear during times of extreme stress, but they’ll gradually increase in intensity over several months. Potential symptoms include:


1.Weight loss

2.Fatigue

3.Dizziness

4.Fainting

5.Muscle weakness

6.Abdominal pain

7.Diarrhea

8.Constipation


When cortisol levels abruptly drop to life-threatening levels, an acute adrenal crisis may occur. The symptoms of an acute adrenal crisis include:


1.Darkening of the skin

2.Extreme weakness

3.Vomiting

4.Diarrhea

5.Fainting

6.Chills

7.Loss of appetite

8.Sudden onset of severe pain in the lower back, abdomen, or legs.


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Albumin commonly exists in the blood and is filtered by the kidneys. The presence or absence of albumin determines the functionality of the kidneys. It is said that small quantities of albumin leak into the urine when the kidneys do not function properly. This condition is known as microalbuminuria. A microalbumin test diagnosis urine for the presence of albumin.

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This test finds out how much 5-hydroxyindoleacetic acid (5-HIAA) is in your urine.


Your liver breaks down the hormone serotonin into 5-HIAA. This waste product is normally sent from your body in your urine. Tumors called functioning carcinoids secrete serotonin. Carcinoid tumors are found in the intestinal tract, lungs, appendix, and other body tissues. Because serotonin in the blood is broken down very quickly, the amount of 5-hydroxyindoleacetic acid collected in the urine over a full day more accurately reflects the rate at which serotonin is being made than the blood level at one particular time. 

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Acid- Fast Bacilli (AFB) smear and culture are two separate tests always performed together at the MSPHL, Tuberculosis (TB) Unit. AFB smear refers to the microscopic examination of a fluorochrome stain of a clinical specimen. The AFB culture is the inoculation of a clinical specimen onto culture media Becton-Dickinson Mycobacteria Growth Indicator Tube (B-D MGIT broth) and Lowenstein-Jensen (L-J) media slant, incubation at 37°C for up to six (6) weeks and detection of growth or no growth during this incubation period. Tuberculosis usually attacks the lungs but can also affect other parts of the body. It is spread through the air when people who have the disease cough, sneeze, or spit. The other widely used tests used in the diagnosis & screening of Tuberculosis infection are:AFB, smear examinationCulture, Mycobacterium TuberculosisMantoux test (Tuberculin skin test)Mycobacterium antibody panel (TB-IgG, IgM, IgA)Mycobacterium Tuberculosis by RT-PCRQuantiferon TB Gold.

The Acid Fast Bacilli - Sputum is done for routine health screenings, to identify the acid-fast bacilli in sputum, fluid or tissue specimen and to manage the medication of mycobacterial infections such as tuberculosis. It may also be used when an atypical mycobacterial infection is suspected.

The Acid Fast Bacilli is generally ordered on suspicion of tuberculosis. The most common symptom of tuberculosis is a chronic cough that produces mucus and sometimes contains blood streaks. Other symptoms of tuberculosis include chest pain, weakness, chills, fever and unexplained weight loss.


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White blood cells are an important part of your body’s immune system. They’re vital to protecting you from invading bacteria, viruses, and parasites. Your bone marrow produces all five of the different kinds of white blood cells in the body.


Each white blood cell lives anywhere from several hours to several days in the blood stream. An eosinophil is a type of white blood cell. Eosinophils are stored in tissues throughout the body, surviving for up to several weeks. The bone marrow continually replenishes the body’s white blood cell supply.


The number and type of each white blood cell in your body can give doctors a better understanding of your health. Elevated levels of white blood cells in your blood can be an indicator that you have an illness or infection. Elevated levels often mean your body is sending more and more white blood cells to fight off infections.


An eosinophil count is a blood test that measures the quantity of eosinophils in your body. Abnormal eosinophil levels are often discovered as part of a routine complete blood count (CBC) test.


Ongoing research continues to uncover an expanding list of roles performed by eosinophils. It appears now that nearly every system of the body relies on eosinophils in some way. Two important functions are within your immune system. Eosinophils destroy invading germs like viruses, bacteria, or parasites such as hookworms. They also have a role in the inflammatory response, especially if an allergy is involved.


Inflammation is neither good nor bad. It helps isolate and control the immune response at the site of an infection, but a side effect is tissue damage around it. Allergies are immune responses that often involve chronic inflammation. Eosinophils play a significant role in the inflammation related to allergies, eczema, and asthma.

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The number of neutrophils in the blood is expressed as absolute neutrophil count (ANC) and it measures the percentage of neutrophils in the differential WBC count. The ANC of a healthy individual falls in the range of 2,500 to 6,000 per microliter.

A total blood count gives the levels of the three types of blood cells - white blood cells, red blood cells, and platelets. Neutrophils are present in two forms – polys and bands. Polys are also known as segmented neutrophils and are the most abundant of the WBCs. Bands are also called stabs and are immature polys. Both polys and bands destroy invaders (i.e. microbes) in the body.

The ANC is calculated by multiplying the number of WBCs in blood by the percentage of total neutrophils.  For example, for a WBC count of 7000 per microliter, if neutrophils constitute 40% of the WBCs, the ANC in this case will be 7000 × 0.40 = 2800 per microliter.

An ANC below 1,000 per microliter is called neutropenia. ANCs less than 500 per microliter significantly increase the risk of infection. In cancer patients, frequent blood tests are performed to assess WBC count and ANC to monitor the body’s response to cancer treatment.

Neutrophils constitute nearly 55 to 70% of the total WBC count. Acute infections or trauma are the main triggers for production of neutrophils leading to elevated WBC count also known as neutrophilia or neutrophil leukocytosis.

In cancer patients, ANC is a reflection of the immunologic status of the patient in response to chemotherapy. This therapy suppresses production of WBC and hence neutrophils, thus increasing infection risks. Hence, a low ANC or neutropenia can be an indication of the need for reducing chemotherapy dosage or delaying the next sessions of chemotherapy. ANC also allows prediction of neutropenia-related events including fever after chemo­therapy sessions. It thus offers a clear picture of the patient’s immunologic status.

ANC helps determine the need for antibiotics or other measures along with therapy to decrease complications related to neutro­penia. While for an in-patient, a low ANC may be an indicator of the need to isolate the patient so as to protect him or her from exposure to infectious agents, in case of an out-patient, it can highlight the need to keep away from crowds or people having flu or colds. ANC is thus a powerful monitoring tool in cancer patients who are prone to bone marrow suppression due to radiation, chemotherapy, or bone marrow transplant.



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Most of the time blood is drawn from a vein on the inside of the elbow or the back of the hand. The site is cleaned with an antiseptic. The health care provider wraps an elastic band around your upper arm to make the vein swell with blood.


Next, the provider gently inserts a needle into the vein. The blood collects into an airtight tube attached to the needle. The elastic band is removed from your arm. The needle is then removed and the site is covered to stop bleeding.


In infants or young children, a sharp tool called a lancet may be used to prick the skin. The blood collects in a small glass tube, or onto a slide or test strip. A bandage is put on the spot to stop bleeding.


In the lab, the blood is placed on a microscope slide. A stain is added to the sample. This causes eosinophils to show up as orange-red granules. The technician then counts how many eosinophils are present per 100 cells. The percentage of eosinophils is multiplied by the white blood cell count to give the absolute eosinophil count.

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Approximately 85-90% of patients with myasthenia gravis (MG) express antibodies to the acetylcholine receptor (AChR), which can be divided into binding, blocking, and modulating antibodies. Binding antibody can activate complement and lead to loss of AChR. Blocking antibody may impair AChR binding to the receptor, leading to poor muscle contraction. Modulating antibody causes receptor endocytosis resulting in loss of AChR expression, which correlates most closely with clinical severity of disease. Approximately 10-15% of individuals with confirmed myasthenia gravis have no measurable binding, blocking, or modulating antibodies. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.


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Your pituitary gland is a pea-sized gland located at the base of your brain. It produces many types of hormones, including the adrenocorticotropic hormone (ACTH).


ACTH stimulates the adrenal glands, which sit atop the kidneys, to release two hormones: cortisol and adrenaline (also known as epinephrine). These hormones help you respond to stress in a healthy way and support your immune system. Cortisol is a steroid hormone that affects many different systems in the body, including your:


circulatory system

immune system

nervous system

bone metabolism

metabolism of nutrients such as carbohydrates, fats, and protein

Adrenaline, or epinephrine, is a hormone responsible for maintaining normal nervous system and circulatory function. This hormone, along with another hormone called norepinephrine, are responsible for your protective fight-or-flight response when you face a stressful situation.


Your healthcare provider might have you take an ACTH (cosyntropin) test if they suspect your adrenal glands aren’t functioning properly. This test requires you to receive an injection of cosyntropin, a synthetic portion of ACTH. You will also have two blood samples drawn — one before the injection and one after the injection. These samples measure the level of cortisol in your blood.


This ACTH stimulation test measures how your adrenal glands react to the ACTH in your blood. It does this by measuring your body’s cortisol levels. It’s important not to confuse this test with an ACTH test, which simply measures the ACTH levels in your blood.

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Alpha-fetoprotein (AFP) is a single polypeptide chain glycoprotein with a molecular weight of approximately 70,000 daltons. Synthesis of AFP occurs primarily in the liver and yolk sac of the fetus. It is secreted in fetal serum, reaching a peak at approximately 13 weeks gestation, after which it rapidly declines until about 22 weeks gestation and then gradually declines until term. Transfer of AFP into maternal circulation is accomplished primarily through diffusion across the placenta. Maternal serum AFP levels rise from the normal nonpregnancy level of 0.20 ng/mL to about 250 ng/mL at 32 weeks gestation.


If the fetus has an open neural tube defect, AFP is thought to leak directly into the amniotic fluid causing unexpectedly high concentrations of AFP. Other fetal abnormalities such as omphalocele, gastroschisis, congenital renal disease, and esophageal atresia; and other fetal distress situations such as threatened abortion, prematurity, and fetal demise, may also show AFP elevations. Decreased amniotic fluid AFP values may be seen when gestational age has been overestimated.

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Alpha-fetoprotein (AFP) is a glycoprotein that is produced in early fetal life by the liver and by a variety of tumors including hepatocellular carcinoma, hepatoblastoma, and nonseminomatous germ cell tumors of the ovary and testis (eg, yolk sac and embryonal carcinoma). Most studies report elevated AFP concentrations in approximately 70% of patients with hepatocellular carcinoma. Elevated AFP concentrations are found in 50% to 70% of patients with nonseminomatous testicular tumors.(1)


AFP is elevated during pregnancy. Persistence of AFP in the mother following birth is a rare hereditary condition.(2) Neonates have markedly elevated AFP levels (>100,000 ng/mL) that rapidly fall to below 100 ng/mL by 150 days and gradually return to normal over their first year.(2)


Concentrations of AFP above the reference range also have been found in serum of patients with benign liver disease (eg, viral hepatitis, cirrhosis), gastrointestinal tract tumors and, along with carcinoembryonic antigen in ataxia telangiectasia.

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The skin of the inner forearm is the usual test site for allergy testing using the Skin Prick Test method. One can also take a blood sample for allergy testing and measure Total Immunoglobulin E (IgE) which is the marker antibody for allergy sensitisation. Then there are the Phadiatop inhalant screen, Food Allergy screens and over 450 individual RAST or ImmunoCAP tests available.


We can quantify allergy severity with another cellular marker, this is the Eosinophil cell in the blood stream. Eosinophils are also found in the allergy sufferer’s phlegm, gullet secretions and nasal mucous. Lung function tests are important in asthma diagnosis, and tests include Peak Flow (PF), Forced Expiratory Volume in 1 second (FEV1) and Forced Vital Capacity (FVC). Measurement of Nitric Oxide (NO) in exhaled air is another measure of allergic inflammation and indicates poor control or ineffective treatment

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Alpha-2-macroglobulin is a protease inhibitor and is 1 of the largest plasma proteins. It transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis system.


Increased levels of alpha-2-macroglobulin are found in nephrotic syndrome when other lower molecular weight proteins are lost and alpha-2-macroglobulin is retained because of its large size. In patients with liver cirrhosis and diabetes, the levels are found to be elevated.


Patients with acute pancreatitis exhibit low serum concentrations which correlate with the severity of the disease. In hyperfibrinolytic states, after major surgery, in septicemia and severe hepatic insufficiency, the measured levels of alpha-2-macroglobulin are often low. Acute myocardial infarction patients with low alpha-2-macroglobulin have been reported to have a significantly better prognosis with regard to the >1 year survival time.

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Under normal physiologic conditions, the usual daily dietary intake of aluminum (5-10 mg) is completely eliminated. Excretion is accomplished by avid filtration of aluminum from the blood by the glomeruli of the kidney. Patients in renal failure (RF) lose the ability to clear aluminum and are candidates for aluminum toxicity. Many factors increase the incidence of aluminum toxicity in patients in RF:


-Aluminum-laden dialysis water can expose dialysis patients to aluminum.


-Aluminum-laden albumin can expose patients to an aluminum burden they cannot eliminate.


-The dialysis process is not highly effective at eliminating aluminum.


-Aluminum-based phosphate binder gels are administered orally to minimize phosphate accumulation; a small fraction of this aluminum may be absorbed and accumulated.


If it is not removed by renal filtration, aluminum accumulates in the blood where it binds to proteins such as albumin and is rapidly distributed through the body. Aluminum overload leads to accumulation of aluminum at 2 sites: brain and bone. Brain deposition has been implicated as a cause of dialysis dementia. In bone, aluminum replaces calcium at the mineralization front, disrupting normal osteoid formation.


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Fatigue can be described as the lack of energy and motivation (both physical and mental). This is different than drowsiness, a term that describes the need to sleep. Often a person complains of feeling tired and it is up to the health care professional to distinguish between fatigue and drowsiness, though both can occur at the same time. Aside from drowsiness, other symptoms can be confused with fatigue including shortness of breath with activity and muscle weakness. Again, all these symptoms can occur at the same time. Also, fatigue can be a normal response to physical and mental activity; in most normal individuals it is quickly relieved (usually in hours to about a day, depending on the intensity of the activity) by reducing the activity.

Fatigue is a very common complaint and it is important to remember that it is a symptom and not a disease. Many illnesses can result in the complaint of fatigue and they can be physical, psychological, or a combination of the two.

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Antineutrophil cytoplasmic antibodies (ANCA) can occur in patients with autoimmune vasculitis including Wegener's granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis.(1) Detection of ANCA is a well-established diagnostic test for the evaluation of patients suspected of having autoimmune vasculitis. ANCA react with enzymes in the cytoplasmic granules of human neutrophils including proteinase 3 (PR3), myeloperoxidase (MPO), elastase, and cathepsin G. Antibodies to PR3 occur in patients with WG (both classical WG and WG with limited end-organ involvement) and produce a characteristic pattern of granular cytoplasmic fluorescence on ethanol-fixed neutrophils called the cANCA pattern. Antibodies to MPO occur predominately in patients with MPA and produce a pattern of perinuclear cytoplasmic fluorescence on ethanol-fixed neutrophils called the pANCA pattern.

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Your thyroid is a gland located in your neck. It releases hormones that control your metabolism. It produces a number of different proteins, including thyroglobulin. Your thyroid uses thyroglobulin to make the active thyroid hormones.


If you have an autoimmune condition, it can disrupt your production of thyroglobulin. An autoimmune condition happens when your immune system creates antibodies that attack your body’s own healthy cells. When your immune system attacks the thyroid, it often targets thyroglobulin. This causes it to produce antithyroglobulin antibodies. Your doctor can order an antithyroglobulin antibody test to check the level of these antibodies in your bloodstream. A high level may indicate an autoimmune condition

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Arginine vasopressin (AVP), or antidiuretic hormone (ADH), is a nonapeptide produced by the hypothalamus and released from the posterior pituitary in response to extracellular fluid hyperosmolarity and hypovolemia. AVP promotes concentration of the urine by increasing water reabsorption in the kidney tubules. Inadequate AVP action causes diabetes insipidus (DI), a syndrome characterized by nonglycosuric polyuria, polydipsia, and dehydration. Central DI refers to insufficient AVP release due to diseases of the hypothalamus, pituitary stalk, and pituitary gland. Nephrogenic DI is the result of impaired renal responsiveness to AVP and may be congenital or due to renal disease, hypokalemia, hypercalcemia, systemic disorders (eg, multiple myeloma and amyloidosis), or drugs (eg, lithium or demeclocycline and ethanol).


DI diagnosis is based on the presence of hyperosmolar serum with inappropriately dilute urine. Central and nephrogenic DI can be differentiated by measuring the plasma AVP level and interpreting it in light of the simultaneous plasma osmolality.


The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is manifested by hyponatremia and inappropriately concentrated urine. The diagnosis is confirmed by plasma or urine AVP levels inappropriate for serum osmolality.

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Abdominal ultrasonography, diagnostic paracentesis, and ascitic fluid cultures are recommended by the British Society of Gastroenterology, the European Association for the Study of the Liver (EASL), and the American Association for the Study of Liver Diseases (AASLD), particularly in the setting of supsected infection. [1]


Laparoscopy may be valuable for the diagnosis of otherwise unexplained cases, especially if malignant ascites is suspected. [6]  This may be of particular importance in the diagnosis of malignant mesothelioma.

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Aspergillus precipitin is a laboratory test performed on your blood. It’s ordered when a doctor suspects that you have an infection caused by the fungus Aspergillus.


The test may also be called:


aspergillus fumigatus 1 precipitin level test

aspergillus antibody test

aspergillus immunodiffusion test

test for precipitating antibodies


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Volume regulation and hemodynamic functions change during pregnancy, leading to marked increases in blood volume and cardiac output, peripheral vasodilatation and reduced sensitivity to angiotensin. Atrial natriuretic peptide (ANP) is intimately involved in fluid and sodium homeostasis and exerts marked relaxant activity on vascular smooth muscle pre-contracted with angiotensin. This study was performed to clarify the role of ANP as a regulator of maternal physiology.

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Hepatitis B virus (HBV) is endemic throughout the world. The infection is spread primarily through percutaneous contact with infected blood products (eg, blood transfusion, sharing of needles by intravenous drug addicts). The virus is also found in various human body fluids, and it is known to be spread through oral and genital contacts. HBV can be transmitted from mother to child during delivery through contact with blood and vaginal secretions, but it is not commonly transmitted transplacentally.

 

Hepatitis B surface antigen (HBsAg) is the first serologic marker appearing in the serum at 6 to 16 weeks following exposure to HBV. In acute infection, HBsAg usually disappears in 1 to 2 months after the onset of symptoms. Persistence of HBsAg for more than 6 months in duration indicates development of either a chronic carrier state or chronic HBV infection.

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B-type natriuretic peptide (BNP) is a hormone produced by your heart. N-terminal (NT)-pro hormone BNP (NT-proBNP) is a non-active prohormone that is released from the same molecule that produces BNP. Both BNP and NT-proBNP are released in response to changes in pressure inside the heart. These changes can be related to heart failure and other cardiac problems. Levels goes up when heart failure develops or gets worse, and levels goes down when heart failure is stable. In most cases, BNP and NT-proBNP levels are higher in patients with heart failure than people who have normal heart function.

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Beta-2-microglobulin (beta-2-M) is a small membrane protein (11,800 Dalton) associated with the heavy chains of class I major histocompatibility complex proteins and is, therefore, on the surface of all nucleated cells. The small size allows beta-2-M to pass through the glomerular membrane, but it is almost completely reabsorbed in the proximal tubules.


Serum beta-2-M levels are elevated in diseases associated with increased cell turnover. Levels are also elevated in several benign conditions such as chronic inflammation, liver disease, renal dysfunction, some acute viral infections, and a number of malignancies, especially hematologic malignancies associated with the B-lymphocyte lineage.


In multiple myeloma, beta-2-M is a powerful prognostic factor and values <4 mcg/mL are considered a good prognostic factor.


In renal tubular disease, serum levels are low and urine levels are high. Although urine beta-2-M has been used to assess tubular dysfunction, it is not stable in urine below pH 5.5.


See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.

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This test looks for bilirubin in your blood or urine.

Bilirubin is a substance made when your body breaks down old red blood cells. This is a normal process. Bilirubin is also part of bile, which your liver makes to help digest the food you eat.


A small amount of bilirubin in your blood is normal. Healthy adults make 250 to 350 milligrams (mg) of bilirubin each day.

Bilirubin that is bound to a certain protein (albumin) in the blood is called unconjugated, or indirect, bilirubin. Conjugated, or direct, bilirubin travels from the liver into the small intestine. A very small amount passes into your kidneys and is excreted in your urine. This bilirubin also gives urine its distinctive yellow color.


This test is usually done to look for liver problems, such as hepatitis, or blockages, such as gallstones.

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Bilirubin is a yellow pigment that’s in everyone’s blood and stool. Sometimes the liver can’t process the bilirubin in the body. This can be due to an excess of bilirubin, an obstruction, or inflammation of the liver. When your body has too much bilirubin, your skin and the whites of your eyes will start to yellow. This condition is called jaundice. A bilirubin test will help determine if you have any of these conditions.


Bilirubin is made in the body when the hemoglobin protein in old red blood cells is broken down. The breakdown of old cells is a normal, healthy process. After circulating in your blood, bilirubin then travels to your liver. In the liver, bilirubin is conjugated, mixed into bile, and then excreted into the bile ducts and stored in your gallbladder. Eventually, the bile is released into the small intestine to help digest fats. It’s ultimately excreted within your stool.


Bilirubin attached by the liver to the glucose-derived acid, glucuronic acid, is called direct, or conjugated, bilirubin. Bilirubin not attached to glucuronic acid is called indirect, or unconjugated, bilirubin. All the bilirubin in your blood together is called total bilirubin.


A comprehensive bilirubin blood test will get an accurate count of all three bilirubin levels in your blood: direct, indirect, and total.


In both adults and children, symptoms related to high bilirubin can involve jaundice, a yellowing of the skin or eyes, fatigue, itchy skin, dark urine, and low appetite.

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A Liver Function Test, also known as LFT, refers to a series of tests carried out to gather information about a patient’s liver conditions. Certain diseases of the liver, which seem mild in their initial stages, can develop to become chronic later on. Hence, proper diagnosis of liver conditions is pretty crucial for the detection and control of these ailments in time.


Liver function tests are performed on blood samples of the patients, and check the levels of various enzymes and proteins present in it. There are enzymes that get released into the blood only when the liver has undergone some damage. While some of the tests are carried out for functionality, a few others may be performed to check the condition of the biliary tract. Cellular integrity tests are also included in the series.


Liver function tests (LFTs), are a group of blood tests that provide details about the liver and identify any inflammation, malfunctioning or damage to the liver. Liver tests may be done together in a panel or tested separately. The list of tests include: Total Protein Albumin Bilirubin (Total & Direct) Gamma-glutamyl transpeptidase (GGT) Alkaline phosphatase (ALP) Serum Glutamic Oxaloacetic Transaminase (SGOT) or AST Serum Glutamate Pyruvate Transaminase (SGPT) or ALT.

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Arterial blood gases (ABGs) are commonly used for estimating the acid-base status, oxygenation and carbon dioxide concentration of unwell patients. However, arterial blood can be difficult to obtain due to weak pulses or patient movement. Due to thicker, muscular and innervated walls, arteries are also more painful to puncture than veins. As such, a venous blood gas (VBG) is an alternative method of estimating pH and other variables.

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Blood typing is a test that determines a person’s blood type. The test is essential if you need a blood transfusion or are planning to donate blood. Not all blood types are compatible, so it’s important to know your blood group. Receiving blood that’s incompatible with your blood type could trigger a dangerous immune response.

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This is a blood test for brucellosis. Brucellosis is an infectious disease usually caused by handling animals or milk products infected with the brucella bacteria. If you have brucellosis, your body will make certain antibodies to fight the brucella bacteria. This test looks for those antibodies in your blood.


The brucella bacteria can infect dogs and livestock, including cows, sheep, camels, goats, and pigs. Recently brucella bacteria have also been found in ocean mammals, including seals.


The disease is rare in the U.S. Fewer than 200 cases are reported here each year. It's more commonly found in Latin America, the Middle East, and the Mediterranean. This is why it's often called Mediterranean or Malta fever. It's also called Undulant fever, Bang's disease, and Gibraltar fever.


If you are exposed to brucella bacteria, you may develop brucellosis. Your symptoms may not show up right away. But if the disease isn't treated after a few months, you may start to feel unusually weak. You may get a fever and chills, headaches, backache, muscle and joint pain, and sweats. You may lose your appetite and appear anorexic. If untreated, the bacteria can sometimes damage the heart, joints, or central nervous system. They can also cause infections that keep coming back. If you are pregnant and have brucellosis, it may cause a miscarriage or infect your unborn child. 

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The test is a simple method to identifying a person’s gender and establish sexual identity in newborns and in adults. Earlier the method was popularly employed in competitive sports to identify males masquerading as females. 


The mouth has to be rinsed and washed before the test. A spatula is used to gently scrape the inside of the person’s cheek. This can be done by a health care provider or by self. A smear of this buccal sample is made on a slide, stained and observed under the microscope.

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A BUN, or blood urea nitrogen test, can provide important information about your kidney function. The main job of your kidneys is to remove waste and extra fluid from your body. If you have kidney disease, this waste material can build up in your blood and may lead to serious health problems, including high blood pressure, anemia, and heart disease.


The test measures the amount of urea nitrogen in your blood. Urea nitrogen is one of the waste products removed from your blood by your kidneys. Higher than normal BUN levels may be a sign that your kidneys aren't working efficiently.


People with early kidney disease may not have any symptoms. A BUN test can help uncover kidney problems at an early stage when treatment can be more effective.


Other names for a BUN test: Urea nitrogen test, serum BUN

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C-peptide is a substance, a short chain of amino acids, that is released into the blood as a byproduct of the formation of insulin by the pancreas. This test measures the amount of C-peptide in a blood or urine sample.


In the pancreas, within specialized cells called beta cells, proinsulin, a biologically inactive molecule, splits apart to form one molecule of C-peptide and one molecule of insulin. Insulin is vital for the transport of glucose into the body's cells and is required on a daily basis. When insulin is required and released from the beta cells into the blood in response to increased levels of glucose, equal amounts of C-peptide are also released. Since C-peptide is produced at the same rate as insulin, it is useful as a marker of insulin production.


In particular, C-peptide testing can be used to help evaluate the production of insulin made by the body (endogenous) and to help differentiate it from insulin that is not produced by the body but is taken in as diabetic medication (exogenous) and so does not generate C-peptide. This test may be done in conjunction with an insulin test.





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The toxicity of cadmium resembles the other heavy metals (arsenic, mercury, and lead) in that it attacks the kidney; renal dysfunction with proteinuria with slow onset (over a period of years) is the typical presentation.


Breathing the fumes of cadmium vapors leads to nasal epithelial deterioration and pulmonary congestion resembling chronic emphysema.


The most common source of chronic exposure comes from spray painting of organic-based paints without use of a protective breathing apparatus; aut

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Calcium is an important mineral that your body uses in many ways. It increases the strength of your bones and teeth and helps your muscles and nerves function.


A serum calcium blood test measures the total calcium in your blood. There are several different forms of calcium in your blood. These include ionized calcium, calcium bound to other minerals called anions, and calcium bound to proteins like albumin. Ionized calcium, also known as free calcium, is the most active form.

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A calcium blood test measures the amount of calcium in your blood. Calcium is one of the most important minerals in your body. You need calcium for healthy bones and teeth. Calcium is also essential for proper functioning of your nerves, muscles, and heart. About 99% of your body's calcium is stored in your bones. The remaining 1% circulates in the blood. If there is too much or too little calcium in the blood, it may be a sign of bone disease, thyroid disease, kidney disease, or other medical conditions.

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Medullary thyroid cancer can be highly aggressive, especially if the diagnosis is done in advanced stages. Early diagnosis is based on RET genetic testing, for familial forms, and on the routine measurement of calcitonin (Ct). Nevertheless, since false-positive results can be obtained with the basal measurement of Ct, a provocative test to evaluate stimulated Ct is often needed. Pentagastrin which has been widely used to stimulate basal Ct, especially in European countries, is now hardly available. Thus, the stimulation with calcium (Ca), used in the 1970s-1980s and then abandoned for around 30 years, has recently elicited more interest. In the past 3 years, studies in patients and normal controls have demonstrated that the stimulation with Ca (2.3-2.5 mg/kg of elemental Ca, corresponding to 25 mg/kg of Ca gluconate) is highly potent and accurate. Novel gender-related cut-offs have been proposed for the Ca test, though the analysis of additional large series is predicted to modify these preliminary data. Finally, Ca seems to be the test of choice to stimulate Ct for the diagnosis and follow-up of medullary thyroid cancer, also because it is widely available, has a low cost and it is associated with a low number and intensity of side effects. In the present review the different methods to stimulate Ct and the cut-offs for the identification of the hyperplastic/neoplastic transformation of the C cells will be reported and discussed.

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Ceruloplasmin, a glycoprotein produced in the liver, carries or transports more than 95 percent of the copper in blood plasma.


Copper plays an important role in the body by aiding crucial bodily processes. These include producing energy, forming connective tissue, and helping your central nervous system function.


A ceruloplasmin test can determine the levels of ceruloplasmin in your body. It’s most often used in the diagnosis of Wilson’s disease, a genetic disorder.

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Chikungunya virus (ChikV) is a single-stranded RNA alphavirus and a member of the Togaviridae family of viruses. The name Chikungunya is derived from the language of the Makonde ethnic groups in southeast Africa and means "that which bends" or "stooped walk." This is in reference to the hunched-over appearance of infected individuals due to the characteristically painful and incapacitating arthralgia caused by the virus. ChikV is endemic throughout Africa, India, and more recently the Caribbean islands. In 2014, the first case of autochthonous or local transmission in the United States occurred in Florida. 


Humans are the primary reservoir for ChikV and Aedes species mosquitos are the primary vectors for transmission. Unlike other mosquito-borne viruses such as West Nile virus (WNV) and Dengue, the majority of individuals who are exposed to ChikV become symptomatic, with the most severe manifestations observed at the extremes of age and in those with suppressed immunity. Once exposed to ChikV virus, individuals develop lasting immunity and protection from reinfection.


The incubation period, prior to development of symptoms, ranges on average from 3 to 7 days. Infected patients typically present with sudden onset high fever, incapacitating joint pain, and often a maculopapular rash lasting anywhere from 3 to 10 days. Notably, symptom relapse can occur in some individuals 2 to 3 months following resolution of initial symptoms. Currently, there are no licensed vaccines and treatment is strictly supportive care.

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Chromium (Cr) exists in valence states ranging from 2(-) to 6(+). Hexavalent chromium (Cr[+6]) and trivalent chromium (Cr[+3]) are the 2 most prevalent forms. Cr(+6) is used in industry to make chromium alloys including stainless steel, pigments, and electroplated coatings. Cr(+6), a known carcinogen, is immediately converted to Cr(+3) upon exposure to biological tissues. Cr(+3) is the only chromium species found in biological specimens.


Serum Cr concentrations are likely to be increased above the reference range in patients with metallic joint prosthesis. Prosthetic devices produced by Depuy Company, Dow Corning, Howmedica, LCS, PCA, Osteonics, Richards Company, Tricon, and Whiteside typically are made of chromium, cobalt, and molybdenum. This list of products is incomplete, and these products change occasionally; see prosthesis product information for each device for composition details.

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The diagnosis of pheochromocytoma/paraganglioma (PPGL) involves detection of elevated levels of plasma and/or 24-h urine catecholamines and/or their metabolites, including metanephrines. Although these tests are reasonably sensitive, false-positive results are often encountered. Follow-up tests can provide additional information to correctly diagnose PPGL. In this regard, the utility of the urinary clonidine suppression test (UCST) remains unknown.

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Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-globulin.

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors (serpins) which have evolved by duplication events.


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Cryptococcosis is an invasive fungal infection caused by Cryptococcus neoformans or C gattii. C neoformans has been isolated from several sites in nature, particularly weathered pigeon droppings. C gatti was previously only associated with tropical and subtropical regions; however, more recently this organism has also been found to be endemic in British Columbia and among the Pacific Northwest United States, and is associated with several different trees species.

Infection is usually acquired via the pulmonary route. Patients are often unaware of any exposure history. Approximately half of the patients with symptomatic disease have a predisposing immunosuppressive condition such as AIDS, steroid therapy, lymphoma, or sarcoidosis. Symptoms may include fever, headache, dizziness, ataxia, somnolence, and cough. While the majority of C neoformans infections occur in immunocompromised patient populations, C gattii is has a higher predilection for infection of healthy hosts.(1,2)

In addition to the lungs, cryptococcal infections frequently involve the central nervous system (CNS), particularly in patients infected with HIV. Mortality among patients with CNS cryptococcosis may approach 25% despite antibiotic therapy. Untreated CNS cryptococcosis is invariably fatal. Disseminated disease may affect any organ system and usually occurs in immunosuppressed individuals.

The presence of cryptococcal antigen in any body fluid (serum or cerebrospinal fluid) is indicative of cryptococcosis. Specimens that are positive by the lateral flow assay screen are automatically repeated with the same method utilizing dilutions in order to generate a titer value.

Disseminated infection is usually accompanied by a positive serum test.

Higher Cryptococcus antigen titers appear to correlate with more severe infections. Declining titers may indicate regression of infection. However, monitoring titers to cryptococcal antigen should not be used as a test of cure or to guide treatment decisions, as low level titers may persist for extended periods of time following appropriate therapy and the resolution of infection.(3)

A negative result does not preclude diagnosis of cryptococcosis, particularly if only a single specimen has been tested and the patient shows symptoms consistent with cryptococcosis. 

A positive result is indicative of cryptococcosis, however all test results should be reviewed in light of other clinical findings.

Testing should not be performed as a screening procedure for the general populations and should only be performed when clinical evidence suggests the diagnosis of cryptococcal disease.

Testing hemolyzed serum specimens may lead to false-negative results due to the high background color on the lateral flow assay strip.

Although rare, extremely high concentrations of cryptococcal antigen can result in weak test lines and in extreme instances, yield negative test results.



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Cryptococcosis is an invasive fungal infection caused by Cryptococcus neoformans or Cryptococcus gattii. C. neoformans has been isolated from several sites in nature, particularly weathered pigeon droppings. C. gatti was previously only associated with tropical and subtropical regions; however, more recently this organism has also been found to be endemic in British Columbia and among the pacific northwest United States, and is associated with several different trees species.


Infection is usually acquired via the pulmonary route. Patients are often unaware of any exposure history. Approximately half of the patients with symptomatic disease have a predisposing immunosuppressive condition such as AIDS, steroid therapy, lymphoma, or sarcoidosis. Symptoms may include fever, headache, dizziness, ataxia, somnolence, and cough. While the majority of C. neoformans infections occur in immunocompromised patient populations, C.gattii is has a higher predilection for infection of healthy hosts.(1,2)


In addition to the lungs, cryptococcal infections frequently involve the central nervous system (CNS), particularly in patients infected with HIV. Mortality among patients with CNS cryptococcosis may approach 25% despite antibiotic therapy. Untreated CNS cryptococcosis is invariably fatal. Disseminated disease may affect any organ system and usually occurs in immunosuppressed individuals.

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Cerebrospinal fluid (CSF) analysis is a set of laboratory tests that examine a sample of the fluid surrounding the brain and spinal cord. This fluid is an ultrafiltrate of plasma. It is clear and colorless. It contains glucose, electrolytes, amino acids, and other small molecules found in plasma, but has very little protein and few cells. CSF protects the central nervous system from injury, cushions it from the surrounding bone structure, provides it with nutrients, and removes waste products by returning them to the blood. CSF is withdrawn from the subarachnoid space through a needle by a procedure called a lumbar puncture or spinal tap. CSF analysis includes tests in clinical chemistry, hematology, immunology, and microbiology. Usually three or four tubes are collected. The first tube is used for chemical and/or serological analysis and the last two tubes are used for hematology and microbiology tests. This reduces the chances of a falsely elevated white cell count caused by a traumatic tap (bleeding into the subarachnoid space at the puncture site), and contamination of the bacterial culture by skin germs or flora.




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Cytomegalovirus (CMV) is a common virus that occurs widely throughout the population but rarely causes symptoms. In the United States, as many as 50-85% of adults have been infected with CMV. Most people are infected as children or as young adults and do not experience any significant symptoms or health problems.


CMV testing involves either a measurement of CMV antibodies, immune proteins produced in response to CMV exposure, or the detection of the virus itself. The virus can be identified during an active infection by culturing CMV or by detecting the virus's genetic material (its DNA) in a fluid or tissue sample.


CMV is found in many body fluids during an active infection, including saliva, urine, blood, breast milk, semen, vaginal secretions, and cerebrospinal fluid. It is easily transmitted to others through close physical contact or by contact with infected objects, such as diapers or toys. After the initial "primary" infection has resolved, CMV becomes dormant or latent, like other members of the herpes family. Cytomegalovirus remains in a person for the rest of the person's life without causing any symptoms unless the person's immune system is significantly weakened. If this happens, the virus can reactivate.


CMV can cause notable health problems in three situations:


In young adults, primary CMV infection may cause a flu-like or mononucleosis-type illness. This condition, which causes symptoms such as extreme fatigue, fever, chills, body aches and/or headaches, usually resolves within a few weeks. 

In infants, primary CMV infection may cause serious physical and developmental problems. This occurs when a woman is infected for the first time (primary infection) during pregnancy and then passes the infection to her developing baby across the placenta. Most newborns (about 90%) who are infected appear healthy at birth but may develop hearing or vision problems, pneumonia, seizures, and/or delayed mental development a few months later. A few babies may be stillborn, while others may have symptoms at birth such as jaundice, anemia, an enlarged spleen or liver, and a small head.

In those with weakened immune systems, CMV could cause serious illness and death. This includes those with HIV/AIDS, those who have had organ or bone marrow transplants, and those undergoing chemotherapy treatment for cancer. People with compromised immune systems who become infected for the first time (primary infection) might experience the most severe symptoms and their CMV infection may remain active. Those who have been exposed to CMV previously may reactivate their infection. This could affect their eyes (causing inflammation of the retina, which can lead to blindness), digestive tract (causing bloody diarrhea and abdominal pain), lungs (causing pneumonia with a non-productive cough and shortness of breath), and brain (causing encephalitis). There can also be spleen and liver involvement, and those who have had organ or bone marrow transplants may experience some degree of rejection. Active CMV also further depresses the immune system, allowing other secondary infections such as fungal infections, to occur.

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Dengue fever is a viral infection transmitted to humans by mosquitoes that live in tropical and subtropical climates and carry the virus. Blood testing detects the dengue virus or antibodies produced in response to dengue infection.


According to the Centers for Disease Control and Prevention (CDC), dengue infections have been reported in more than 100 countries from parts of Africa, the Americas, the Caribbean, the Eastern Mediterranean, Southeast Asia, and the Western Pacific. It is a fast emerging infectious disease, according to the World Health Organization (WHO), with an increasing number of cases and countries affected throughout the world. The actual number is not known because about 75% of cases are asymptomatic, but a recent estimate put the number of annual dengue infections as high as 390 million. Approximately 50 to 100 million symptomatic cases occur annually worldwide.


In the U.S., the majority of dengue cases occur in travelers returning from areas where dengue is endemic. Most dengue cases in U.S. citizens occur in people who live in Puerto Rico, the U.S. Virgin Islands, Samoa and Guam. Outbreaks where a large number of cases occur in a defined area are rare in the U.S. In recent years, there have been small outbreaks in Texas and Hawaii and a few cases diagnosed in southern Florida.

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A dexamethasone suppression test is primarily used to help diagnose Cushing syndrome. Cushing syndrome indicates that you have an abnormally high level of cortisol. Cortisol is a steroid hormone produced by the body during high levels of stress. (Abnormally low cortisol levels can be a sign of Addison’s disease, which is not diagnosed by this test.)

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Drugs of abuse testing is the detection of one or more illegal and/or prescribed substances in the urine, blood, saliva, hair, or sweat. Testing detects substances not normally found in the body, with the exception of some hormones and steroids measured as part of sports testing.


Drug abuse testing usually involves an initial screening test followed by a second test that identifies and/or confirms the presence of a drug or drugs. Most laboratories use commercially available tests that have been developed and optimized to screen urine for the "major drugs of abuse."


For most drugs of abuse testing, laboratories compare results of initial screening with a predetermined cut-off. Anything below that cut-off is considered negative; anything above is considered a positive screening result. In addition, labs might perform testing for masking agents (adulterants). These may either interfere with testing or dilute a urine sample.


Among drugs of abuse, each class of drug may contain a variety of chemically similar substances. Legal substances that are chemically similar to illegal ones can produce a positive screening result. Positive screening tests are considered presumptive. Therefore, screening tests that are positive for one or more classes of drugs are frequently confirmed with a secondary test that identifies the exact substance present using a very sensitive and specific method, such as gas chromatography/mass spectrometry (GC/MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS).

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Electrolytes are minerals that are found in body tissues and blood in the form of dissolved salts. As electrically charged particles, electrolytes help move nutrients into and wastes out of the body's cells, maintain a healthy water balance, and help stabilize the body's acid/base (pH) level.


The electrolyte panel measures the blood levels of the main electrolytes in the body: sodium (Na+), potassium (K+), chloride (Cl-), and bicarbonate (HCO3-; sometimes reported as total CO2).


A person's diet provides sodium, potassium, and chloride. The kidneys help maintain proper levels by reabsorption or by elimination into the urine. The lungs provide oxygen and regulate CO2. The CO2 is produced by the body and is in balance with bicarbonate. The overall balance of these chemicals is an indication of the functional well-being of several basic body functions. They are important in maintaining a wide range of body functions, including cardiac and skeletal muscle contraction and nerve impulse conduction.


Any disease or condition that affects the amount of fluid in the body, such as dehydration, or affects the lungs, kidneys, metabolism, or breathing has the potential to cause a fluid, electrolyte, or pH imbalance (acidosis or alkalosis). Normal pH must be maintained within a narrow range of 7.35-7.45 and electrolytes must be in balance to ensure the proper functioning of metabolic processes and the delivery of the right amount of oxygen to tissues. (For more on this, see the condition article on Acidosis and Alkalosis and also on Dehydration.)

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The pemphigus   Pemphigus foliaceus  and pemphigoid   Skin: bullous pemphigoid  autoimmune skin diseases   Immune-mediated disease: overview   are mediated by autoantibodies that target antigens within the interkeratinocyte desmosomes (pemphigus) or the basement membrane zone hemidesmosomes (pemphigoid).

A range of laboratory methods may be used to demonstrate the presence of these autoantibodies. These tests have not been used widely in equine pemphigus or pemphigoid diseases and, in those report available, have shown variable sensitivity and specifity.

Autoantibodies may be detected either in situ(within lesional skin biopsies), or circulating with the serum of affected animals.

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Epstein-Barr virus (EBV) is a virus that typically causes a mild to moderate illness. Blood tests for Epstein-Barr virus detect antibodies to EBV in the blood and help establish a diagnosis of EBV infection.


Epstein-Barr virus causes an infection that is very common. According to the Centers for Disease Control and Prevention (CDC), most people in the United States are infected by EBV at some point in their lives. The virus is very contagious and easily passed from person to person. It is present in the saliva of infected individuals and can be spread through close contact such as kissing and through sharing utensils or cups.


After initial exposure to EBV, there is a period of several weeks before associated symptoms may appear, called the incubation period. During the acute primary infection, the virus multiplies in number. This is followed by a decrease in viral numbers and resolution of symptoms, but the virus never completely goes away. Latent EBV remains in the person's body for the rest of that person's life and may reactivate but usually causes few problems unless the person's immune system is significantly weakened.


Most people are infected by EBV in childhood and experience few or no symptoms. However, when the initial infection occurs in adolescence, it can cause infectious mononucleosis, commonly called mono, a condition associated with fatigue, fever, sore throat, swollen lymph nodes, an enlarged spleen, and sometimes an enlarged liver. These symptoms occur in about 25% of infected teens and young adults and usually resolve within a month or two.


People with mono are typically diagnosed by their symptoms and the findings from a complete blood count (CBC) and a mono test (which tests for a heterophile antibody). About 25% of those with mono do not produce heterophile antibodies and will have a negative mono test; this is especially true with children. Tests for EBV antibodies can be used to determine whether or not the symptoms these people are experiencing are due to a current infection with the EBV virus.


EBV is the most common cause of mono. According to the CDC, examples of other causes of mono include cytomegalovirus (CMV), hepatitis A, hepatitis B or hepatitis C, rubella, and toxoplasmosis. Sometimes, it can be important to distinguish EBV from these other illnesses. For instance, it may be important to diagnose the cause of symptoms of a viral illness in a pregnant woman. Testing can help to distinguish a primary EBV infection, which has not been shown to affect a developing baby, from a CMV, herpes simplex virus, or toxoplasmosis infection, as these illnesses can cause complications during the pregnancy and may harm the fetus.


It can also be important to rule out EBV infection and to look for other causes of the symptoms. Those with strep throat, an infection caused by group A streptococcus, for instance, need to be identified and treated with antibiotics. A person may have strep throat instead of mono or may have both conditions at the same time.


Several tests for different types and classes of EBV antibodies are available. The antibodies are proteins produced by the body in an immune response to several different Epstein-Barr virus antigens. During a primary EBV infection, the level of each of these EBV antibodies rises and falls at various times as the infection progresses. Measurement of these antibodies in the blood can aid in diagnosis and typically provides the healthcare practitioner with information about the stage of infection and whether it is a current, recent, or past infection.

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Fibrin degradation products (FDP) are substances that remain in your bloodstream after your body dissolves a blood clot. Your fibrinolytic (clot-busting) system manages and regulates clot dissolving.


When you cut yourself, the injured blood vessel constricts to stop bleeding and promote healing. This process is called hemostasis. Platelets in your blood gather together and stick to the injury site to form a plug or clot. The formation of the plug or clot is called the clotting cascade.


Fibrin is a protein that aids in clotting. Clotting, also called coagulation, at the wound site produces a mass of fibrin threads called a net. The net remains in place until the cut is healed. As the cut heals, the clotting slows down. Eventually the clot breaks down and dissolves.


When the clot and fibrin net dissolve, fragments of protein are released into the body. These fragments are fibrin degradation products (FDPs). If your body is unable to dissolve a clot, you may have abnormal levels of FDPs.


Blood tests can measure your level of FDPs to see if you have a clotting disorder. The fibrin degradation products test is a specific test that determines the amount of FDPs in your blood. The test is also known as the fibrin split products (FSPs) test, or the fibrin breakdown products test.

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The fluorescent treponemal antibody absorption (FTA-ABS) test is a blood test that checks for the presence of antibodies to Treponema pallidum bacteria. These bacteria cause syphilis.


Syphilis s a sexually transmitted infection (STI) that’s spread through direct contact with syphilitic sores. Sores are most often present on the penis, vagina, or rectum. These sores aren’t always noticeable. You may not even know that you’re infected.


The FTA-ABS test doesn’t actually check for the syphilis infection itself. However, it can determine whether you have antibodies to the bacteria that cause it. Antibodies are special proteins produced by the immune system when harmful substances are detected. These harmful substances, known as antigens, include viruses, fungi, and bacteria. This means that people who are infected with syphilis will have the corresponding antibodies.

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Fructosamine is a glycated serum protein which is formed by the combination of glucose and protein in the blood. Higher the levels of blood glucose, higher will be the concentration of fructosamine. Hence, the blood fructosamine levels reflect the amount of glucose present. Glycation mainly involves albumin which is the principal blood protein. Other protein substance may also combine with glucose. These protein substances have a lifespan of about 2-3 weeks. By measuring the level of fructosamine, you get an idea of the level of blood glucose over the past 2-3 weeks. Fructosamine test is usually performed on a blood sample to measure the level of fructosamine in blood. The test is performed to confirm Diabetes and also useful in estimating the blood sugar trends in the diabetic patient.

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Fungi are microbes that exist in nature as one-celled yeasts or as branching filamentous molds (also may be spelled "moulds"). Only about 20 to 25 species of fungi are common causes of infection. Fungal tests detect infections and sometimes identify the fungus and help guide treatment. 


Fungal infections range from superficial skin infections to serious deep tissue, blood, lung, or systemic diseases.


Superficial fungal infections are very common. They may cause nail infections or itchy, red, scaly skin infections such as those commonly known as athlete's foot, jock itch, and ringworm, or yeast infections that cause white patches in the mouth (thrush) or vaginal itching and discharge. According to the Centers for Disease Control and Prevention (CDC), almost 75% of women will have at least one yeast infection in their lifetime.

Lung, blood, and systemic infections: less commonly, fungi cause serious lung infections, blood infections (septicemia), or systemic infections that can affect any organ in the body. Fungal lung infections typically start with the accidental inhalation of microscopic fungal spores. While anyone can get a serious lung or systemic fungal infection, most affected people will only experience mild to moderate flu-like symptoms. However, people who are immunocompromised, such as those with HIV/AIDS, organ transplant recipients, and people with an underlying condition such as diabetes or lung disease are at an increased risk of having a severe fungal infection, a systemic infection, and/or recurrent infections.

Fungal tests are used to detect and identify fungi in order to diagnose infections and help guide treatment. Fungal testing typically includes a microscopic examination of the sample on a slide, sometimes using a preparation or stain to aid in detection of fungal elements. This may be sufficient to determine that the infection is due to a fungus and, with superficial infections, no further testing may be required.


However, in cases of persistent, deep, or systemic infections when a more definitive diagnosis is needed, the microscopic exam may be followed by additional tests, such as culture and susceptibility testing, antigen or antibody tests, or molecular tests that detect fungal genetic material.

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Fungal Smear test is performed on a sample of skin to measure the level of Fungal Smear (Skin) in the skin.It is performed to confirm Fungal Infection of Skin and also during the treatment and after the treatment of Fungal Infection of Skin and Immunosuppressive Condition.

No special preparation is needed for Fungal Smear Koh Test Skin. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Fungal Smear Koh Test Skin. Your doctor depending on your condition will give specific instructions.

The normal result for Fungal Smear Koh Test Skin for Fungal Smear (Skin) is A normal KOH test result shows no Fungi. A stained slide fluoresce is observed if positive for fungus. A positive test indicates Fungal infection but it cannot identify the organism. If KOH test is positive then, specimen is inoculated into culture media. for Unisex gender and for All age groups.


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Frequent urination is a condition defined when the need to urinate is felt several times an hour, caused by the false impression of once again having a full bladder. The quantity of urine passed during the day is not, however, larger, as the urinations are very small in volume. Daytime frequent urination is assessed based on the frequency with which the patient has to go to the toilet. This false impression is most of the time due to an irritation in one of the urinary organs. There can be many different underlying causes of this irritation, such as inflammation of the bladder, called cystitis or more commonly urinary infection, or prostatitis, which is an inflammation or benign swelling of the prostate in men.


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GCT test is used to help diagnose gestational diabetes and type 2 diabetes. A glucose tolerance test measures how well your body’s cells are able to absorb glucose, or sugar, after you ingest a given amount of sugar.

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Gamma-glutamyl transferase (GGT) is an enzyme that is found in many organs throughout the body, with the highest concentrations found in the liver. GGT is elevated in the blood in most diseases that cause damage to the liver or bile ducts. This test measures the level of GGT in a blood sample.


Normally, GGT is present in low levels, but when the liver is injured, the GGT level can rise. GGT is usually the first liver enzyme to rise in the blood when any of the bile ducts that carry bile from the liver to the intestines become obstructed, for example, by tumors or stones. This makes it the most sensitive liver enzyme test for detecting bile duct problems.


However, the GGT test is not very specific and is not useful in differentiating between various causes of liver damage because it can be elevated with many types of liver diseases, such as liver cancer and viral hepatitis, as well as other non-hepatic conditions, such as acute coronary syndrome. For this reason, the GGT test is not recommended for routine use by itself. However, it can be useful in conjunction with other tests and in determining the cause of a high alkaline phosphatase (ALP) level, another enzyme found in the liver.


Both GGT and ALP are increased in liver diseases, but only ALP will be increased with diseases affecting bone tissue. Therefore, GGT can be used as a follow up to an elevated ALP to help determine if the high ALP result is due to liver or bone disease.


GGT levels are sometimes increased with consumption of even small amounts of alcohol. Higher levels are found more commonly in chronic heavy drinkers than in people who consume less than 2 to 3 drinks per day or who only drink heavily on occasion (binge drinkers). The GGT test may be used in evaluating someone for acute or chronic alcohol abuse.

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A glucagon blood test measures the amount of a hormone called glucagon in your blood. Glucagon is produced by cells in the pancreas. It helps control your blood sugar level by increasing blood sugar when it is too low.

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C-peptide is a substance, a short chain of amino acids, that is released into the blood as a byproduct of the formation of insulin by the pancreas. This test measures the amount of C-peptide in a blood or urine sample.


In the pancreas, within specialized cells called beta cells, proinsulin, a biologically inactive molecule, splits apart to form one molecule of C-peptide and one molecule of insulin. Insulin is vital for the transport of glucose into the body's cells and is required on a daily basis. When insulin is required and released from the beta cells into the blood in response to increased levels of glucose, equal amounts of C-peptide are also released. Since C-peptide is produced at the same rate as insulin, it is useful as a marker of insulin production.


In particular, C-peptide testing can be used to help evaluate the production of insulin made by the body (endogenous) and to help differentiate it from insulin that is not produced by the body but is taken in as diabetic medication (exogenous) and so does not generate C-peptide. This test may be done in conjunction with an insulin test.

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Blood sugar (glucose) is usually present in the urine at very low levels or not at all. Abnormally high amounts of sugar in the urine, known as glycosuria, are usually the result of high blood sugar levels. High blood sugar usually occurs in diabetes, especially when untreated. It serves as the main source of energy used by the body. Insulin is a hormone that helps the body's cells to use the glucose. Excess or shortage of insulin in the body causes an imbalance of the blood glucose in the body, leading to its severe drop or drastic increase in the blood. Blood glucose levels that remain high over time can cause damage to the eyes, kidneys, nerves and blood vessels. Chronic low glucose levels can lead to brain and nerve damage.


Fasting blood sugar is a test for glucose content in a person’s blood that, as the name suggests, is conducted after fasting. The test is generally carried out in the morning, after an overnight fasting. As a part of the test, a sample of the patient’s blood is collected and then sent to the lab for testing.


A fasting blood sugar test offers information about how the body is managing the blood sugar levels. Normally, the range of glucose in a person’s blood is between 70 to 100 mg/dl. Fasting blood sugar levels between 100 to 126 mg/dl are considered as pre-diabetic or impaired fasting glucose and blood sugar levels of 126 mg/dl or higher are diagnosed as diabetes.

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This is a blood test to check for diabetes. If you have diabetes, your body doesn't make enough insulin to keep your blood sugar in check. This means your blood sugar levels are too high, and over time this can lead to serious health problems including nerve and eye damage.


This test is done to see how your body responds to sugar and starch after you eat a meal. As you digest the food in your stomach, blood glucose, or blood sugar, levels rise sharply. In response, your pancreas releases insulin to help move these sugars from the blood into the cells of muscles and other tissues to be used for fuel. Within two hours of eating, your insulin and blood glucose levels should return to normal. If your blood glucose levels remain high, you may have diabetes.

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Blood sugar (glucose) is usually present in the urine at very low levels or not at all. Abnormally high amounts of sugar in the urine, known as glycosuria, are usually the result of high blood sugar levels. High blood sugar usually occurs in diabetes, especially when untreated. It serves as the main source of energy used by the body. Insulin is a hormone that helps the body's cells to use the glucose. Excess or shortage of insulin in the body causes an imbalance of the blood glucose in the body, leading to its severe drop or drastic increase in the blood. Blood glucose levels that remain high over time can cause damage to the eyes, kidneys, nerves and blood vessels. Chronic low glucose levels can lead to brain and nerve damage.

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Gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard to identify central precocious puberty (CPP). This test requires multiple blood samples at different time points to measure gonadotropin levels, and is therefore expensive, time-consuming, and uncomfortable for patients. We aimed to simplify the GnRH stimulation test to require fewer blood samples.

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Growth hormone (GH) is secreted in a pulsatile manner and is cleared rapidly, resulting in dramatic fluctuations in GH levels.1-3 For this reason, random GH levels are generally not useful in establishing GH deficiency. A number of physiologic and pharmacologic stimuli can be used to provoke GH release. Several growth hormone stimulation protocols are described below. These tests are best performed in the morning after an overnight fast.3 Patients should be confirmed as euthyroid before these protocols are initiated.

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At least 3 blood samples are taken.


The test is done in the following way:


The first blood sample is collected between 6 a.m. and 8 a.m before you eat or drink anything.

You then drink a solution containing glucose (sugar). You may be told to drink slowly to avoid becoming nauseated. But you must drink the solution within 5 minutes to ensure the test result is accurate.

The next blood samples are usually collected for 1 to 2 hours after you finish drinking the glucose solution. Sometimes they are taken every 30 or 60 minutes.

Each sample is sent to the laboratory right away. The lab measures the glucose and growth hormone (GH) levels in each sample.

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A glucose tolerance test measures how well your body’s cells are able to absorb glucose, or sugar, after you ingest a given amount of sugar. Doctors use fasting blood sugar levels and hemoglobin A1c values to diagnose type 1 and type 2 diabetes, and prediabetes. A glucose tolerance test can also be used. Doctors primarily use a glucose tolerance test to diagnose gestational diabetes.


Doctors often diagnose type 1 diabetes quickly because it usually develops quickly and involves high blood sugar levels. Type 2 diabetes, on the other hand, often develops over years. Type 2 diabetes is the most common form of diabetes, and it usually develops during adulthood.


Gestational diabetes occurs when a pregnant woman who doesn’t have diabetes before pregnancy has high blood sugar levels as a result of the pregnancy. The American Diabetes Association estimates that gestational diabetes occurs in 9.2 percent of pregnancies.

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Fungal infections of the skin are very common and include athlete's foot, jock itch, ringworm, and yeast infections.

Athlete's Foot:-

Picture of Ringworm of the Foot (Tinea Pedis)Athlete's foot, also called tinea pedis, is a fungal infection of the foot. It causes peeling, redness, itching, burning, and sometimes blisters and sores.

Athlete's foot is a very common infection. The fungus grows best in a warm, moist environment such as shoes, socks, swimming pools, locker rooms, and the floors of public showers. It is most common in the summer and in warm, humid climates. It occurs more often in people who wear tight shoes and who use community baths and pools.
 

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When the plasma hemoglobin level is >50 to 200 mg/dL after hemolysis, the capacity of haptoglobin to bind hemoglobin is exceeded, and hemoglobin readily passes through the glomeruli of the kidney. Part of the hemoglobin is absorbed by the proximal tubular cells where the hemoglobin iron is converted to hemosiderin. When these tubular cells are later shed into the urine, hemosiderinuria results. If all of the hemoglobin cannot be absorbed into the tubular cells, hemoglobinuria results.

Hemosiderin is found as yellow-brown granules that are free or in epithelial cells and occasionally in casts in an acidic or neutral urine.

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Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It is one of several various causes of hepatitis, a condition characteriszed by inflammation and enlargement of the liver. Other causes of hepatitis include, for example, certain drugs, inherited disorders, and autoimmune diseases. HBV is one of five "hepatitis viruses" identified so far. The other four are A, C, D, and E. 


The course of HBV infections can vary from a mild form (acute) that lasts only a few weeks to a more serious, chronic, form lasting years. Sometimes chronic HBV leads to serious complications such as cirrhosis or liver cancer. 


HBV is spread through contact with blood or other body fluids from an infected person. Exposure can occur, for example, through sharing of needles for IV drug use or through unprotected sex. People who live in or travel to areas of the world where hepatitis B is prevalent are at a greater risk. Mothers can pass the infection to their babies, usually during or after birth. The virus, however, is not spread through food or water, casual contact such as holding hands, or coughing or sneezing.

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The human epidermal growth factor receptor 2 (HER2) gene is responsible for producing HER2 proteins. HER2 proteins are receptors that are present on some breast cancer cells. When they’re activated, these receptors signal breast cancer cells to divide and multiply. Normally, HER2 receptors regulate and control the growth of breast cells, keeping them at a healthy level.

However, the HER2 gene is overexpressed in about one in every five cases of breast cancer. This means that instead of having one copy of the gene from each parent, you have multiple HER2 genes. When this occurs, it’s known as HER2 gene amplification

These additional genes then make too many HER2 receptors. This is known as HER2 protein receptor overexpression. Too many genes and too many receptors cause breast cells to grow and divide in an uncontrolled manner. This can lead to aggressive tumor growth.


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The HLA gene products can be grouped into three classes. Class I consists of the products of the genes located on the HLA-A, HLA-B, and HLA-C loci. These HLA antigens are found on all nucleated cells. Class II molecules consist of antigens inherited as genes from the HLA-DR, HLA-DQ, and HLA-DP loci. These HLA antigens are normally found only on B-lymphocytes, macrophages, monocytes, dendritic cells, endothelial cells, and activated T-lymphocytes. Class III molecules are not evaluated in histocompatibility testing.Because the HLA loci are closely linked, the HLA antigens are inherited as a group of six antigens is called a haplotype. The probability of siblings having identical haplotypes is one in four. Therefore, siblings provide the opportunity for the best matches. They can donate bone marrow, a kidney, and a section of their livers, but they cannot donate other solid organs. Approximately 85% of transplants are organs from cadavers, and because the HLA antigens are so highly polymorphic, the chance of identical haplotypes decreases quickly.

Histocompatibility testing consists of three tests, HLA antigen typing (tissue typing), screening of the recipient for anti-HLA antibodies (antibody screen), and the lymphocyte crossmatch (compatibility test). HLA antigen typing may be performed by serological or DNA methodsA laboratory will perform HLA typing by either the serological (blood fluid) or DNA method. In either case, HLA typing of HLA-A, HLA-B, HLA-DR, and HLADQ antigens is performed for solid organ transplants. HLA typing of HLA-C antigens is also included when tissue typing is performed for bone marrow transplantsThe antibody screen is performed in order to detect antibodies in the recipient's serum that react with HLA antigens. The most commonly used method of HLA antibody screening is the microcytotoxicity test. If an antibody against an HLA antigen is present, it will bind to the cells. The higher the number of different HLA antibodies, the lower the probability of finding a compatible matchThe third component of a histocompatibility study is the crossmatch test. In this test peripheral blood lymphocytes from the donor are separated into B and T lymphocyte populations. In the crossmatch, serum from the recipient is mixed with T-cells or B-cells from the donor. A positive finding indicates the presence of preformed antibodies in the recipient that are reactive against the donor tissues. An incompatible T-cell crossmatch contraindicates transplantation of a tissue from the T-cell donor.


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Despite the morbidity associated with anogenital condylomas and the mortality associated with anal, penile, and cervical carcinoma as a direct consequence of human papillomavirus (HPV), the US Centers for Disease Control and Prevention currently does not recommend routine screening for HPV in immuno competent men. However, findings of emerging research focusing on the high-risk populations of men who have sex with men and men who test positive for human immunodeficiency virus, in whom HPV infection is pervasive and persistent, suggest that these populations may benefit from screening. Therefore, HPV screening, including anal cytology, should be considered for these men in settings where appropriate follow-up, including high-resolution anoscopy, is available.

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An IgA test measures the blood level of immunoglobulin A, one of the most common antibodies in the body. Antibodies are proteins made by the immune system to fight bacteria, viruses, and toxins.IgA is found in high concentrations in the body's mucous membranes, particularly the respiratory passages and gastrointestinal tract, as well as in saliva and tears. IgA also plays a role in allergic reactions. IgA levels also may be high in autoimmune conditions, disorders in which the body mistakenly makes antibodies against healthy tissues.

 

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This test measures the amount of Immunoglobulin E (IgE) in the blood.   Immunoglobulin E is a type of antibody produced by the body during an allergic reaction.  IgE levels are normally very low.  During exposure to an allergen, the immune system of the allergic person creates IgE which triggers typical allergy symptoms such as red itchy skin, runny nose, itchy eyes and difficulty breathing.  Measuring IgE levels can help determine if a person may have an allergic disease including asthma although it cannot identify a specific allergen.  IgE can also be elevated when a person has a parasitic infection.   


A Total IgE test is typically ordered when a person is experiencing symptoms associated with a parasitic infection or allergic reaction, especially if they do not know what they may be allergic to.  The test is usually taken shortly after or while someone is experiencing symptoms such as persistent itching, hives, itchy eyes, nausea, vomiting, diarrhea, sneezing, coughing, congestion or difficulty breathing.  This test is usually accompanied by or followed with testing for specific allergens. 

 

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 This test measures the level of Immunoglobulin G (IgG) Antibodies in the blood.  IgG are the smallest and most common type of antibody making up 75-80% of all antibodies in the body.  IgG antibodies are found in all body fluids and play a key role in fighting infections from bacteria and viruses. High IgG levels may indicate that a person has a chronic infection such as HIV or Hepatitis.  They can also be high due to conditions such as Multiple Sclerosis, some types of cancer and autoimmune disorders.  Low IgG levels can be found in people with kidney damage, leukemia and conditions which weaken the immune system leaving them more susceptible to infections. IgG test results cannot indicate the specific type or source of an infection.  More specific testing may be needed as a follow up to abnormal results.  An IgG test may be ordered when someone is suffering from frequent infections to see if they have a condition which is impairing their immune system. 


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The gamma-globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 5% is immunoglobulin M (IgM)Elevations of IgM may be due to polyclonal immunoglobulin production. Monoclonal elevations of IgM occur in macroglobulinemia.Monoclonal gammopathies of all types may lead to a spike in the gamma-globulin zone seen on serum protein electrophoresis.Decreased immunoglobulin levels are found in patients with congenital deficiencies.


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Inhibin is a hormone secreted by granulosa cells in the ovarian follicles and by Sertoli cells in the testis. Its physiological role is to suppress secretion of follicle stimulating hormone (FSH) by the pituitary.Inhibin exists as two different isoforms, inhibin A and inhibin B. Both isoforms are comprised of 2 subunits, the alpha and beta subunits. The alpha subunit is the same for both inhibin A and B, but the beta subunit differs. Inhibin A contains a beta-A subunit and inhibin B contains a beta-B subunit. Plasma levels of inhibin A and B fluctuate during the menstrual cycle. At menopause, serum inhibin A and B decrease to very low or undetectable levels.


Ninety five percent of ovarian cancers are derived from epithelial cells. The remaining 5% are germ cell and sex cord-stromal tumors. Inhibin A is elevated up to 6 times the upper limit of the reference range in approximately 70% of granulosa cell tumors. Inhibin A is also elevated in about 20% of patients with epithelial tumors of the mucinous type. Inhibin is a better tumor marker for these two types of ovarian cancer than cancer antigen 125 (CA 125). Inhibin A is most useful as a tumor marker in postmenopausal women, because plasma levels are normally very low. Inhibin A levels are much harder to interpret in premenopausal women, because plasma levels are higher and fluctuate throughout the menstrual cycle. Because of its low sensitivity, a normal inhibin A level does not rule-out a mucinous or granulosa ovarian cell tumor. Inhibin B might be elevated in these cases.


Inhibin A level decreases shortly after surgery for ovarian cancer. Patients in remission have normal levels of inhibin A. Elevations of inhibin A after treatment are suggestive of residual or recurrent disease. Inhibin A may become elevated prior to onset of clinical symptoms. Inhibin A levels are increased in normal pregnancy, preeclampsia and Down syndrome.Specimen requirement is blood collected into a red top tube. Reference range using a Beckman Coulter Unicel chemiluminescent assay is <2.1 pg/mL for males, <97.5 pg/mL for premenopausal females and <6.9 pg/mL for postmenopausal females. 


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Insulin is produced by the pancreas and used by the body to transport and convert glucose throughout the body into usable energy. Issues with the pancreas including diabetes or a pancreatic tumor can prevent the pancreas from producing the correct amount of insulin to maintain proper glucose levels. Too much insulin causes hypoglycemia, or low glucose levels, while too little, or resistance to, insulin, which is often caused by type 2 diabetes, leads to extremely high levels of glucose. Either situation can lead to severe health issues.Excess insulin production may be due to an insulin producing tumor (insulinoma) and can cause low glucose levels leading to convulsions or loss of consciousness. Acute or chronic symptoms of low blood sugar include sweating, confusion, blurred vision, hunger, fainting or heart palpitations.


Insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, prediabetes, heart disease and polycystic ovarian syndrome (POCS), can lead to extremely high glucose levels in the body. Long term blood sugar levels that are too high cause severe health problems associated with both type 1 and type 2 diabetes including blindness, neuropathy that can lead to foot and leg amputations and cardiovascular disease. The pancreatic system in those with prediabetes or type 2 diabetes becomes damaged over time and is unable to utilize insulin properly. Known as insulin resistance, this condition can be improved with diet and lifestyle changes but may ultimately require injectable insulin.


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Context: Autoantibodies to glutamate decarboxylase, islet antigen-2, insulin, and zinc transporter-8 are characteristic of type 1 diabetes. They are detectable before clinical onset and define the subgroup of patients with latent autoimmune diabetes in adults. Autoantibody assays are increasingly available to clinicians. This article reviews the prognostic significance of autoantibodies and considers the utility of diabetes antibody testing in routine clinical practice.Evidence Acquisition: The medical literature to May 2009 was reviewed for key articles and consensus statements covering use of islet autoantibody testing for prediction and classification of diabetes and implications for therapy.Evidence Synthesis: Sensitive and specific glutamate decarboxylase and islet antigen-2 antibody assays are widely available, although to insulin autoantibody assays remain variable. Islet autoantibodies appear early in life, and testing for multiple antibodies identifies unaffected individuals at very high risk of type 1 diabetes with high sensitivity. This is important for research, but currently no intervention prevents or delays diabetes, and evidence of benefit from awareness of risk is weak. In non-insulin-treated diabetes, patients with autoantibodies progress to insulin requirement more rapidly, but evidence that testing benefits the individual patient is limited. Antibody testing is useful in classifying diabetes of other types.Conclusions: Islet autoantibody testing allows prediction of type 1 diabetes and definition of the latent autoimmune diabetes in adults subgroup of non-insulin-treated patients. Although useful for research, until therapies modulating the disease process become available, the benefit to individual patients is generally questionable. With a few exceptions, diabetes antibody testing does not yet have a role in routine clinical care.


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Lead poisoning through chronic exposure is characterized by gastrointestinal disturbance, anemia, insomnia, weight loss, motor weakness, muscle paralysis, and neuropathy. Ingestion of large quantities may produce death Increased urinary lead excretion indicates excessive lead exposure, regardless of clinical presentation. Erythrocyte protoporphyrin and whole blood lead levels are probably more sensitive indicators of excessive lead exposure. In cases of borderline blood levels, an EDTA lead mobilization test may be considered. Chelation therapy monitoring may be indicated. Lead and organic lead compounds have numerous commercial and industrial applications, use in paints, plastics, storage batteries, bearing alloys, insecticides, and ceramics. Exposure may also occur through the inhalation of dust containing lead emitted by automobile exhausts. A common source of lead exposure among children is derived through the mouthing of inanimate objects, specifically objects with paint and paint chips that contain lead. Acute lead exposure is rare; however, toxicity may occur through acute ingestion of a lead salt or acetate. Urine is suggested specimen in which chronic lead poisoning may be monitored.  BEI® are reference values intended as guidelines for evaluation of occupational exposure. BEI® represent biological levels of chemicals that correspond to workers with inhalation exposure equivalent to the threshold limit value (TLV®) of the chemicals. TLVs refer to the airborne concentrations of substances and represent conditions under which it is believed that nearly all workers may be repeatedly exposed, day after day, without adverse health effects.


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A leukocyte alkaline phosphatase (LAP) test is a laboratory test that can be conducted on a sample of your blood. Your doctor can order it to measure the amount of alkaline phosphatase, a group of enzymes, in certain white blood cells. Before the advent of more advanced tests, the LAP test was commonly use to diagnose chronic myeloid leukemia (CML). This is a type of cancer than affects white blood cells. If you have CML, the level of alkaline phosphatase in your white blood cells will be lower than normal. Some doctors still order the LAP test to check for signs of CML. It can also help them rule out other disorders. But it’s now generally accepted that a cytogenetic test (a test of your cells and chromosomes) is needed to confirm a CML diagnosis. As a result, the LAP test is used less often now than in the past.


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Lithium has been the gold standard drug for treatment in bipolar disorder. It was administered as thrice daily with standard preparation; later twice daily with the availability of sustained release preparations. The efficacy of lithium is dose-dependent and reliably correlates with serum concentrations. Therapeutic efficacy of lithium demands maintenance of serum concentrations in the range of 0.8 and 1.2 mmol/L (trough level).[1] Lower levels are considered to be noneffective, and serum level above this range would lead to side-effects and toxicity. Amdisen[2] proposed the use of a standardized 12 h serum lithium concentration, which subsequently became the universally accepted mode of monitoring lithium levels in patients who have been taking the drug in two or more divided dosages with standard preparations where the last dose would be administered at bed time. It is convenient for the patient to provide a blood sample to check the trough levels before the next morning dose. However, in the current day, clinical practice once a day (OD) dose is being prescribed for reasons of better compliance.[3] The current practice is to measure serum lithium levels at 12 h after the last dosing, irrespective of BD/OD administration.

Now the clinical question is whether this standardized 12 h serum level estimation indicates true trough level when lithium is administered as OD dosage. If not, would it lead to misleading clinical decisions in estimating the correct dose of lithium and also erroneous interpretations of lithium nonresponse? The current study is undertaken to test this hypothesis! To the best of our knowledge, this would be the first study to be published in the literature to determine the appropriate time for serum lithium level estimation for OD administration of sustained release preparations of lithium


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Liver function tests help determine the health of your liver by measuring the levels of proteins, liver enzymes, or bilirubin in your blood.


A liver function test is often given in the following situations: to screen for liver infections, such as hepatitis C

to monitor the side effects of certain medications known to affect the liver

if you already have a liver disease, to monitor the disease and how well a particular treatment is working

to measure the degree of scarring (cirrhosis) on the liver

if you’re experiencing the symptoms of a liver disorder

if you’re planning on becoming pregnant

Many tests can be performed on the liver, but most of them don’t measure the overall function of the liver. Commonly used tests to check liver function are the alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, and bilirubin tests. The ALT and AST tests measure enzymes that your liver releases in response to damage or disease. The albumin and bilirubin tests measure how well the liver creates albumin, a protein, and how well it disposes of bilirubin, a waste product of the blood.

Having abnormal results on any of the liver function tests doesn’t necessarily mean you have liver disease or damage. Talk to your doctor about the results of your liver function test.

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Lupus anticoagulant (LAC) testing is important for evaluating patients with antiphospholipid syndromes and hypercoagulable states. We reviewed results of proficiency testing challenges (n = 5) distributed by the North American Specialized Coagulation Laboratory Association to examine LAC testing performed by participating laboratories. The activated partial thromboplastin time (APTT) and dilute Russell viper venom time (dRVVT) constituted major testing methods. In screening studies, LAC-sensitive APTT methods were more sensitive to weak LAC than dRVVT-based methods but less specific. In confirmatory testing, dRVVT methods performed better, but performance was LAC-dependent. The highest false-negative confirmatory test results were obtained for the platelet neutralization procedure. Noncompliance with recommendations for LAC testing by the International Society on Thrombosis and Haemostasis was high (8%–38%), with the majority of noncompliant laboratories failing to report results of mixing studies. These data provide new insights into LAC testing in North America and identify opportunities for standardization.


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Lyme disease is caused by a bacteria, Borrelia burgdorferi, that’s transmitted to humans through a bite from an infected black-legged or deer tick. Symptoms can occur anywhere from 3 to 30 days after the bite, and symptoms can be wide-ranging, depending on the stage of the infection. The chances you might get Lyme disease from a tick bite depend on the kind of tick, where you were when the bite occurred, and how long the tick was attached to you, according to the CDC. Black-legged ticks must be attached to you for at least 24 hours to transmit Lyme disease.


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Magnesium is important to the functioning of your body and can be found in many common foods. Rich magnesium sources include green vegetables, nuts, seeds, and beans. Your tap water may also contain magnesium. According to the National Institutes of Health (NIH), this mineral plays a role in more than 300 of your body’s biochemical reactions. For example, it helps regulate blood pressure and your heartbeat. It also helps maintain bone strength.Having too little magnesium in your body can negatively affect all of these functions. It’s possible to have too much magnesium as well.If your doctor suspects that your magnesium level is too low or too high, they may order a serum magnesium test. This test involves a basic blood draw. Your doctor will collect some of your blood into a vial or tube and send it to a lab for testing.


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Malaria antigen detection tests are a group of commercially available rapid diagnostic tests of the rapid antigen test type that allow quick diagnosis of malaria by people who are not otherwise skilled in traditional laboratory techniques for diagnosing malaria or in situations where such equipment is not available. There are currently over 20 such tests commercially available (WHO product testing 2008). The first malaria antigen suitable as target for such a test was a soluble glycolytic enzyme Glutamate dehydrogenase.[1][2][3] None of the rapid tests are currently as sensitive as a thick blood film, nor as cheap. A major drawback in the use of all current dipstick methods is that the result is essentially qualitative. In many endemic areas of tropical Africa, however, the quantitative assessment of parasitaemia is important, as a large percentage of the population will test positive in any qualitative assay.

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MCH stands for Mean Corpuscular Hemoglobin, and is a calculation of the average amount of hemoglobin contained within each of a person's red blood cells. Hemoglobin is the substance that carries oxygen from the lungs to the cells of the body through the bloodstream. Abnormally high or low levels of MCH, as determined by blood testing, can be an indication of a number of problems within the body, ranging from nutrient deficiencies to chronic diseases.The MCH blood test is done as a component of a blood test called a Complete Blood Count (CBC), which evaluates the composition of the blood, checking hematocrit, white blood cells (WBC) and platelets as well as hemoglobin and red blood cells (RBC). It is usually ordered to get an overview of general health. MCH is not measured directly, but calculated based on the hemoglobin value (Hgb), which is the total measure of hemoglobin in the blood, and the RBC, which is the number of red blood cells in the blood. To calculate MCH, the Hgb is divided by RCB, yielding an average amount of hemoglobin per red blood cell. Normal levels of MCH are between 26 and 33 picograms (pg) of hemoglobin per RBC.


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The mean corpuscular hemoglobin concentration (MCHC) is the average concentration of hemoglobin in your red blood cells. Hemoglobin is the protein molecule that allows red blood cells to carry oxygen to tissues within your body. Your MCHC can fall into low, normal, and high ranges even if your red blood cell count is normal.


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MCV stands for mean corpuscular volume. There are three main types of corpuscles (blood cells) in your blood–red blood cells, white blood cells, and platelets. An MCV blood test measures the average size of your red blood cells, also known as erythrocytes. Red blood cells move oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. If your red blood cells are too small or too large, it could be a sign of a blood disorder such as anemia, a vitamin deficiency, or other medical condition.


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A rubella blood test detects antibodies that are made by the immune system to help kill the rubella virus. These antibodies remain in the bloodstream for years. The presence of certain antibodies means a recent infection, a past infection, or that you have been vaccinated against the disease. Rubella (also called German measles or 3-day measles) usually does not cause long-term problems. But a woman infected with the rubella virus during pregnancy can transmit the disease to her baby (fetus). And serious birth defects called congenital rubella syndrome (CRS) could develop, especially during the first trimester. Birth defects of CRS include cataracts and other eye problems, hearing impairment, and heart disease. Miscarriage and stillbirth are also possible consequences for pregnant women. The vaccination to prevent rubella protects against these complications.A rubella test is usually done for a woman who is or wants to become pregnant to determine whether she is at risk for rubella. Several laboratory methods can be used to detect rubella antibodies in the blood. The most commonly used method is the enzyme-linked immunosorbent assay (ELISA, EIA).


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Mononucleosis is a viral infection caused by the Epstein Barr virus and is common in adolescents and young adults. Often times, there are no symptoms, but others feel tired, feverish, have a sore throat, etc. The Mononucleosis Test (Qualitative) will detect what’s called ‘heterophil antibodies’ in your blood (related to mono). Keep in mind, if you’ve had mononucleosis in the past, you will always test positive for it.


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Tuberculin is a glycerol extract of the tubercle bacillus. Purified protein derivative (PPD) tuberculin is a precipitate of species-nonspecific molecules obtained from filtrates of sterilized, concentrated cultures. The tuberculin reaction was first described by Robert Koch in 1890. The test was first developed and described by the German physician Felix Mendel in 1908 [1] It is named after Charles Mantoux, a French physician who built on the work of Koch and Clemens von Pirquet to create his test in 1907. However, the test was unreliable due to impurities in tuberculin which tended to cause false results.[2] Esmond R. Long and Florence B. Seibert identified the active agent in tuberculin as a protein. Seibert then spent a number of years developing methods for separating and purifying the protein from Mycobacterium tuberculosis, obtaining purified protein derivative (PPD) and enabling the creation of a reliable test for tuberculosis.[2] Her first publication on the purification of tuberculin appeared in 1934.[3] By the 1940s, Seibert's PPD was the international standard for tuberculin tests.[4] In 1939, M. A. Linnikova in the USSR created a modified version of PPD. In 1954, the Soviet Union started mass production of PPD-L, named after Linnikova.[c


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The mumps virus is a member of the Paramyxoviridae family of viruses, which include parainfluenza virus serotypes 1-4, measles, respiratory syncytial virus, and metapneumovirus. Mumps is highly infectious among unvaccinated individuals and is typically transmitted through inhalation of infected respiratory droplets or secretions. Following an approximately 2-week incubation period, symptom onset is typically acute with a prodrome of low-grade fever, headache, and malaise.(1,2) Painful enlargement of the salivary glands, the hallmark of mumps, occurs in approximately 60% to 70% of infections and in 95% of patients with symptoms. Testicular pain (orchitis) occurs in approximately 15% to 30% of postpubertal men and abdominal pain (oophoritis) is found in 5% of postpubertal women.(1) Other complications include mumps-associated pancreatitis (<5% of cases) and central nervous system disease (meningitis <10% and encephalitis <1%).

Widespread routine immunization of infants with attenuated mumps virus has dramatically decreased the number of reported mumps cases in the United States. However, outbreaks continue to occur, indicating persistence of the virus in the general population. Laboratory diagnosis of mumps is typically accomplished by detection of IgM- and IgG-class antibodies to the mumps virus. However, due to the widespread mumps vaccination program, in clinically suspected cases of acute mumps infection, serologic testing should be supplemented with virus isolation in culture or detection of viral nucleic acid by PCR in throat, saliva, or urine specimens.


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Mycobacterioses (tuberculosis, leprosy, atypical mycobacterioses, paratuberculosis, and perhaps

Crohn’s Disease) are the infectious diseases of men and animals with the largest diffusion on earth.

The infectious agents of tuberculosis are acid-resistant rod-like formed bacteria of the family

Mycobacteriaceae, genus Mycobacterium. The germ was detected by Robert Koch in 1882. Owing

to the very high infectious power of pathogenic mycobacteria, early diagnosis is essential to

prevent spreading of the disease. Convergence of various approaches are necessary to control the

mycobacterioses, immune reactions and bacterial shedding being variable during the diseases.

However, usual diagnostic procedures were up to now unsatisfactory and did not allow to

distinguish among different mycobacterial species. The illness is normally transferred by droplets

of saliva from infected persons. The target of the infection are mostly the lungs, but also other

organs like the brain, intestinal tract, bones, lymph nodes and kidneys can be afflicted.

Tuberculosis is not only found in developing countries with 8 million of new infections yearly, but

also in industrialized civilizations, as an actual disease with some thousands of cases yearly.

Without treatment, the disease leads in 50% of the cases to death within less than two years.

Clinical symptoms are fatigue, loss of weight, lack of appetite, light fever, nocturnal sweat and

pain in the chest. Especially patients with HIV are threatened by tuberculosis due to their impaired

immune system. A vaccination with living attenuated bacteria is possible (BCG = Bacille Calmette

Guérin). This is mostly done with newborn or young children. With older patients, before the

vaccination there is normally performed the tuberculin test (Pirquet or Mantoux), where a small

amount of tuberculin is injected under the skin. In a positive case, there exist antibodies against

Mycobacteria, and a vaccination is not necessary. Up to recently, there have not existed any

serological methods to detect tuberculosis antibodies in serum. The only available procedure was

besides the skin tuberculin test the direct microscopical identification of the dyed bacteria in

sputum. Meanwhile specific antigens have been prepared either by purification of natural material

or by recombinant methods. This ELISA test kit for the determination of IgG antibodies uses a

cocktail of highly pure proteins in order to determine an immune response against the bacteria in

human serum. A fresh or chronically active infection can be diagnosed by IgA and IgM tests,

which are also available. 




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In order to establish a rapid and stable method for diagnosis of Mycobacterium tuberculosis infection and minimize the side effects of delayed diagnosis on patients and health system, a cross sectional study was carried out. Since, the infection rate with this bacteria increasing and one of the reasons for this increase is long process of laboratory identification, therefore establishing new diagnosis methods could decrease disease rate. To achieve this aim, collected sputum and blood specimens from 50 patients with clinical suspicion of pulmonary tuberculosis were studied with both traditional, acid-fast stain (AFB) and culture method compare to Enzyme-linked immunosorbent assay (Elisa) (IgG and IgM) and Polymerase Chain Reaction (PCR) methods. The sensitivity and specificity of all methods were determined by using the PCR results as the gold standard. The overall sensitivity, specificity, positive predictive value and negative predictive value of AFB were 17.64, 100, 100 and 70.12%. These values for culture method was 29.41, 100, 100 and 73.33% and for IgG antibody were 66.7, 81.81, 64.7 and 81.81% and IgM antibody were 70.58, 90.9, 80 and 85.71%, respectively. It was concluded that maximum sensitivity and specificity can be achieved by PCR method.

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Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. Enolase exists in the form of several tissue-specific isoenzymes, consisting of homo or heterodimers of 3 different monomer-isoforms (alpha, beta, and gamma). Neuron specific enolase (NSE) is a 78 kD gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Its levels in other tissues, except erythrocytes, are negligible. The biological half-life of NSE in body fluids is approximately 24 hours.

Due to this organ-specificity, concentrations of NSE in serum or, more commonly, cerebrospinal fluid (CSF), are often elevated in diseases which result in relative rapid (hours/days to weeks, rather than months to years) neuronal destruction. Measurement of NSE in serum of CSF can therefore assist in the differential diagnosis of a variety of neuron-destructive and neurodegenerative disorders. The most common application is in the differential diagnosis of dementias, where elevated CSF concentrations support the diagnosis of rapidly progressive dementias, such as Creutzfeldt-Jacob Disease. NSE might also have utility as a prognostic marker in neuronal injury. There is, for example, increasing evidence that elevated serum NSE levels correlate with a poor outcome in coma, in particular when caused by hypoxic insult.

NSE is also frequently overexpressed by neural crest-derived tumors. Up to 70% of patients with small cell lung carcinoma (SCLC) have elevated serum NSE concentrations at diagnosis, and approximately 90% of patients with advanced SCLC will have serum levels above the healthy reference range. Other neuroendocrine tumors with frequent expression of NSE include carcinoids (up to 66% of cases), islet cell tumors (typically <40% of cases), and neuroblastoma (exact frequency of NSE expression unknown). NSE levels in NSE-secreting neoplasms correlate with tumor mass and tumor metabolic activity. High levels have therefore some negative prognostic value. Falling or rising levels are often correlated with tumor shrinkage or recurrence, respectively.

Serum neuron-specific enolase (NSE) measurement has its greatest utility in the follow-up of patients with tumors of any type that have been shown to secrete NSE. With successful treatment, serum concentrations should fall with a half-life of approximately 24 hours. Persistent NSE elevations in the absence of other possible causes (see Cautions) suggest persistent tumor. Rising levels indicate tumor spread, or in patients who had previously become NSE negative, recurrence.

In the context of a patient with a lung mass, disseminated malignancy of unknown origin or symptoms suggestive of paraneoplastic disease without identifiable tumor, elevated NSE suggests an underlying small cell lung carcinoma (SCLC).


In patients with suspected carcinoid, islet cell tumor, or neuroblastoma, who have no clear elevations in the primary tumor markers used to diagnose these conditions, an elevated serum NSE level supports the clinical suspicion.

1.Carcinoid: chromogranin A, urinary 5-hydroxyindoleacetic acid, serum/blood 5-hydroxytryptamine

2.Islet cell tumors: variety of peptide and amine-derived hormones, chromogranin A

3.Neuroblastoma: vanillylmandelic acid and homovanillic acid


When considered alongside established outcome predictors of coma, such as Glasgow coma scale and other clinical predictors (papillary light responses, corneal reflexes, motor responses to pain, myoclonus, status epilepticus), electroencephalogram, sensory evoked potentials, measurement of serum NSE concentrations provides additional information. Elevated levels are indicative of a poor outcome. Currently, no established algorithms exist to combine serum NSE concentrations and the various other predictors into a composite score that gives clear predictive outcome information. The NSE measurement therefore needs to be considered in a qualitative or semi-quantitative fashion and carefully weighed against other predictors by a physician experienced in examining and managing coma patients.

All neuron-specific enolase (NSE) test results must be considered in the clinical context, and interferences or artifactual elevations should be suspected if the clinical NSE test results are at odds with the clinical picture or other tests. The laboratory should be contacted for assistance in these situations.

Hemolysis can lead to significant artifactual NSE elevations, since erythrocytes contain NSE.

Hemoglobin concentrations as low as 20 mg/dL were found to have an adverse effect on NSE testing.

Proton pump inhibitor treatment, hemolytic anemia, hepatic failure, and end stage renal failure can also result in artifactual NSE elevations.

Other false positives depend on the treating context. When performing NSE testing for tumor diagnosis or follow-up, epileptic seizure, brain injury, encephalitis, stroke, and rapidly progressive dementia might result in false-positive results. On the other hand, when NSE testing is performed to assist in neurological diagnosis, NSE-secreting tumors can represent a source of false-positive results.

NSE values can vary significantly between methods/assays. Serial follow-up should be performed with the same assay. If assays are changed, patients should be re-baselined. This assay is an immunometric assay, and can therefore in rare situations be affected by false low results in the presence of extremely high NSE concentrations ("hooking") or autoantibodies to NSE, as well as by false results in the presence of heterophile antibodies.


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In biology, the nuclear matrix is the network of fibres found throughout the inside of a cell nucleus and is somewhat analogous to the cell cytoskeleton. However, in contrast to the cytoskeleton, the nuclear matrix has been proposed to be a highly dynamic structure, perhaps more like a dynamic sponge with open compartments for free diffusion of molecules in the nucleus.The nuclear matrix, along with the nuclear lamina aid in organizing the genetic information within the cell.

The exact function of this matrix is still disputed, and its very existence has recently been called into question.Evidence for such a structure was recognised as long ago as 1948 (Zbarskii and Debov), and consequently many proteins associated with the matrix have been discovered. The presence of intra-cellular proteins is largely indisputable, and it is well recognized that proteins such as the Scaffold, or Matrix Associated Proteins (SAR or MAR) have some role in the organisation of chromatins. There is evidence that the nuclear matrix is involved in regulation of gene expression in Arabidopsis thaliana.

For a long time the question whether a polymer meshwork, a “nuclear matrix” or “nuclear-scaffold” or "NuMat"is an essential component of the in vivo nuclear architecture has remained a matter of debate. While there are arguments that the relative position of chromosome territories (CTs), the equivalent of condensed metaphase chromosomes at interphase, may be maintained due to steric hindrance or electrostatic repulsion forces between the apparently highly structured CT surfaces, this concept has to be reconciled with observations according to which cells treated with the classical matrix-extraction procedures maintain defined territories up to the point where a minor subset of acidic nuclear matrix proteins is released – very likely those proteins that governed their association with the nuclear skeleton.The nuclear matrix proteome consists of structural proteins, chaperones, DNA/RNA-binding proteins, chromatin remodeling and transcription factors. The complexity of NuMat is an indicator of its diverse structural and functional significance.
S/MARs (scaffold/matrix attachment elements), the DNA regions that are thought to attach genomic DNA to the nuclear skeleton, show an ever increasing spectrum of established biological activities. All these activities are in agreement with (or most easily explained by) the nuclear matrix hypothesis. This is one justification for maintaining this concept before equally plausible alternative models emerge.

S/MARs find increasing use for the rational design of vectors with widespread use in gene therapy and biotechnology. Nowadays S/MAR functions can be modulated, improved and custom-tailored to the specific needs of novel vector systems
The nuclear matrix composition on human cells has been proven to be cell type and tumor specific. It has been clearly demonstrated that the nuclear matrix composition in a tumor is different from its normal counterparts.This fact could be useful to characterize cancer markers and to predict the disease even earlier. These markers have been found in urine and blood and could potentially be used in early detection and prognosis of human cancers.

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Osteocalcin, or bone Gla protein (BGP), is the major noncollagenous protein of bone matrix. It has a molecular weight of approximately 5.8 kilodaltons and consists of 49 amino acids, including three residues of γ-carboxyglutamic acid. Osteocalcin is synthesized in bone by osteoblasts. After production, it is partly incorporated into the bone matrix and partly delivered to the circulatory system. The precise physiological function of osteocalcin is still unclear. A large number of studies have shown that the circulating level of osteocalcin reflects the rate of bone formation.
Determination of serum osteocalcin has proven to be valuable as an aid in identifying women at risk of developing osteoporosis, for monitoring bone metabolism during perimenopause and postmenopause, and during antiresorptive therapy.



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Oxalate (Urine)is a urine test to see whether you have a high level of the chemical oxalate in your urine. Oxalate is a natural end product of metabolism in the body. It should leave your body through your urine. If your oxalate levels are too high, the extra oxalate can combine with calcium to form kidney stones. These stones are hard masses of chemicals that can get stuck in the urinary tract. They commonly cause severe pain. Calcium-oxalate kidney stones are the most common type. Higher levels of oxalate may be caused by eating foods high in oxalate, or by your body absorbing or making too much oxalate.
You may need this test if you have kidney stones often. Your healthcare provider might order this test to help him or her make a recommendation on treatment. It may also be used to find out how well limiting the amount of oxalate in your food is working. You might have this test to see whether you have a rare inherited condition called primary hyperoxaluria and are at risk of developing kidney stones. 

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A common eye condition in which the fluid pressure inside the eye rises to a level higher than healthy for that eye. If untreated, it may damage the optic nerve, causing the loss of vision or even blindness.

The elderly, African-Americans, and people with family histories of the disease are at greatest risk. There are no symptoms in the early stage of glaucoma. Glaucoma is often called "the sneak thief of sight." Often, by the time the patient notices vision loss, glaucoma can only be halted, not reversed.

There are several different types of glaucoma, including open-angle glaucoma and acute angle-closure glaucoma. Open-angle glaucoma is the common adult-onset type of glaucoma. Acute angle-closure glaucoma is a less common form of glaucoma that can rapidly impair vision.

The treatment of glaucoma may include medication, surgery, or laser surgery. Eyedrops or pills alone can usually control glaucoma, although they cannot cure it. Some drugs are designed to reduce pressure by slowing the flow of fluid into the eye, while others help to improve fluid drainage. Surgery to help fluid escape from the eye, and laser surgery is now often used for the same purpose. In laser surgery for glaucoma, a laser beam of light is focused on the part of the anterior chamber where the fluid leaves the eye. This results in a series of small changes, making it easier for fluid to exit. Over time, the effect of laser surgery may wear off.

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The packed cell volume (PCV) is a measurement of the proportion of blood that is made up of cells. The value is expressed as a percentage or fraction of cells in blood. For example, a PCV of 40% means that there are 40 millilitres of cells in 100 millilitres of blood. 
Red blood cells account for nearly all the cells in the blood. The PCV rises when the number of red blood cells increases or when the total blood volume is reduced, as in dehydration. The PCV falls to less than normal, indicating anaemia, when your body decreases its production of red blood cells or increases its destruction of red blood cells.

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The pericardium is a two-layered, sac-like membrane that surrounds the heart. Pericardial membranes produce pericardial fluid, a liquid that sits between the pericardium's membranes. The fluid acts as a lubricant for the movement of the heart, reducing friction as the heart pumps blood.

A variety of conditions and diseases can cause inflammation of the pericardium (pericarditis) and/or excessive accumulation of pericardial fluid (pericardial effusion). Pericardial fluid analysis is a group of tests that evaluate this liquid to help diagnose the cause of the increased fluid.

The two main reasons for fluid accumulation in the pericardial space are:

1.An imbalance between the pressure within blood vessels—which drives fluid out of blood vessels—and the amount of protein in blood—which keeps fluid in blood vessels. The fluid that accumulates in this case is called a transudate. Transudates are most often caused by congestive heart failure or cirrhosis.

2.An injury or inflammation of the pericardium, in which case the fluid that accumulates is called an exudate. Conditions such as infections, malignancies (metastatic cancer, lymphoma, mesothelioma), or autoimmune disease may cause the accumulation of exudate.

Determining if the increased fluid is transudate or exudate is important because it helps narrow down the possible causes of pericardial fluid buildup. Healthcare practitioners and laboratorians use an initial set of tests, including cell count, protein or albumin level, and appearance of the fluid, to distinguish between transudates and exudates. Once the fluid is determined to be one or the other, additional tests may be performed to further pinpoint the disease or condition causing pericarditis and/or pericardial effusion.

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Phosphorus is a mineral that combines with other substances to form organic and inorganic phosphate compounds. The terms phosphorus and phosphate are often used interchangeably when talking about testing, but it is the amount of inorganic phosphate in the blood that is measured with a serum phosphorus/phosphate test.
Phosphates are vital for energy production, muscle and nerve function, and bone growth. They also play an important role as a buffer, helping to maintain the body's acid-base balance.
Phosphorus comes into the body through the diet. It is found in many foods and is readily absorbed by the intestines. About 70-80% of the body's phosphates combine with calcium to help form bones and teeth, another 10% are found in muscle, and about 1% is in nerve tissue. The rest is found within cells throughout the body, where they are mainly used to store energy.
Normally, only about 1% of total body phosphates are present in the blood. A wide variety of foods, such as beans, peas and nuts, cereals, dairy products, eggs, beef, chicken, and fish, contain significant amounts of phosphorus. The body maintains phosphorus/phosphate levels in the blood by regulating how much it absorbs from the intestines and how much it excretes via the kidneys. Phosphate levels are also affected by the interaction of parathyroid hormone (PTH), calcium, and vitamin D.
Phosphorus deficiencies (hypophosphatemia) may be seen with malnutrition, malabsorption, acid-base imbalances, hypercalcemia, and with disorders that affect kidney function. Phosphorus excesses (hyperphosphatemia) may be seen with increased intake of the mineral, hypocalcemia, and with kidney dysfunction.
Someone with a mild to moderate phosphorus deficiency often does not have any symptoms. With a severe phosphorus deficiency, symptoms may include muscle weakness and confusion. An extreme excess of phosphorus may cause symptoms that are similar to those seen with low calcium, including muscle cramps, confusion, and even seizures.

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Platelets, also called thrombocytes, are tiny fragments of cells that are essential for normal blood clotting. They are formed from very large cells called megakaryocytes in the bone marrow and are released into the blood to circulate. The platelet count is a test that determines the number of platelets in a person's sample of blood.
When there is an injury to a blood vessel or tissue and bleeding begins, platelets help stop bleeding in three ways. They:

1.Adhere to the injury site
2.Clump together (aggregate) with other platelets
3.Release chemical compounds that stimulate further aggregation of other platelets

These steps result in the formation of a loose platelet plug at the site of the injury in a process called primary hemostasis. At the same time, activated platelets support the coagulation cascade, a series of steps that involves the sequential activation of proteins called clotting factors. This secondary hemostasis process results in the formation of strands of fibrin that weave through the loose platelet plug, form a fibrin net, and compress to form a stable clot that remains in place until the injury has healed. When the clot is no longer needed, other factors break the clot down and remove it.
Each component of primary and secondary hemostasis must be present, activated at the right time, and functioning properly for adequate clotting. If there are insufficient platelets, or if platelets are not functioning normally, a stable clot may not form and a person may be at an increased risk of excessive bleeding.
Platelets survive in the circulation about 8 to 10 days, and the bone marrow must continually produce new platelets to replace those that degrade, are used up, and/or are lost through bleeding. Determining the number of platelets in blood with a platelet count can help diagnose a range of disorders having to do with too few or too many platelets.

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When a doctor requires a platelet count, then a complete blood count may be ordered. The CBC blood test will include a measurement of platelet distribution width, which is how the PLATELET DISTRIBUTION WIDTH blood test results will be measured. The PLATELET DISTRIBUTION WIDTH is a reflection of how uniform in size a patient’s platelets happen to be. This can help to determine how effectively a person’s bone marrow is functioning and if follow-up tests may be required.
For platelet width, the general rule is that larger platelets are generally younger, while smaller platelets have been around for a few days. Having a high number of large platelets when someone has typically has a low platelet count indicates the bone marrow has stepped up production levels.
Because the PLATELET DISTRIBUTION WIDTH (PDW) is part of a complete blood count, it may be ordered for a wide variety of reasons. The most common issues that doctors will examine are unexplained bruising, bleeding that continues on from small cuts or wounds, numerous nosebleeds, or internal bleeding in the digestive tract. The presence of a continuous rash or purplish spots on the skin may also cause this test to be ordered.
For women, when there is continuous and heavy menstrual bleeding, the PLATELET DISTRIBUTION WIDTH (PDW) blood test may be ordered as well.
If the PDW blood test has abnormal results and if there isn’t a known cause for them, then a doctor may choose to perform additional follow-up tests in an attempt to confirm a diagnosis. This may include testing to find inflammatory conditions, the presence of infectious diseases, kidney failure, or bleeding disorders. Liver disease and iron studies may also be ordered, as will vitamin levels.
In severe instances of abnormality when there is not a definitive cause that can be determined, then a bone marrow biopsy may be ordered.
For patients who live in high altitude area, PDW test results may be affected by an individual’s living habits. Be sure to speak with a doctor about this issue if you have recently spent a at least 30 days in a high altitude climate.
The PDW blood test is generally used as a screening tool to see if a patient is experiencing good health. It is typically ordered as part of a routine health screening. If bone marrow disorders are suspected, however, it may also be ordered. Consider these results, compare them to your own results, and then be sure to speak with your doctor about what this may indicate for you and your unique health history.

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Pleural fluid is found in the pleural cavity and serves as a lubricant for the movement of the lungs during inhalation and exhalation. It is derived from a plasma filtrate from blood capillaries and is found in small quantities between the layers of the pleurae - membranes that cover the chest cavity and the outside of each lung.

A variety of conditions and diseases can cause inflammation of the pleurae (pleuritis) and/or excessive accumulation of pleural fluid (pleural effusion). Pleural fluid analysis comprises a group of tests used to determine the cause. There are two main reasons fluid may collect in the pleural space:


1.Fluid may accumulate in the pleural space because of an imbalance between the pressure within blood vessels—which drives fluid out of blood vessels—and the amount of protein in blood—which keeps fluid in blood vessels. The fluid that accumulates in this case is called a transudate. This type of fluid usually involves both lungs and is often a result of either cirrhosis or congestive heart failure.

2.Fluid accumulation may be caused by injury or inflammation of the pleurae, in which case the fluid is called an exudate. It usually involves one lung and may be seen in infections (pneumonia, tuberculosis, sarcoidosis), malignancies (lung cancer, metastatic cancer, lymphoma, mesothelioma), rheumatoid disease, or systemic lupus erythematosus.

Differentiation between the types of fluid is important because it helps diagnose the specific disease or condition. Doctors and laboratory scientists use an initial set of tests (cell count, albumin and appearance of the fluid) to distinguish between transudates and exudates. Once the fluid is determined to be one or the other, additional tests may be performed to further pinpoint the disease or condition causing pleuritis and/or pleural effusion.




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Pleural fluid is a liquid derived from the blood in the tiny blood vessels (capillaries) in the lungs. It is found in small quantities between the layers of the pleurae – membranes that cover the chest cavity and the outside of each lung. It serves as a lubricant for the movement of the lungs during breathing.
A variety of conditions and diseases can cause inflammation of the pleurae (pleuritis) and/or excessive accumulation of pleural fluid (pleural effusion). Pleural fluid analysis is a group of tests that evaluate this liquid to determine the cause of the increased fluid.

The two main reasons for fluid accumulation in the pleural space are:

1.An imbalance between the pressure of the liquid within blood vessels, which drives fluid out of blood vessels, and the amount of protein in blood, which keeps fluid in blood vessels. The fluid that accumulates in this case is called a transudate. This type of fluid more commonly involves both sides of the chest and is most frequently a result of either congestive heart failure or cirrhosis.
2.An injury to or inflammation of the pleurae, in which case the fluid that accumulates is called an exudate. It more commonly involves one side of the chest and may be seen in infections (pneumonia, tuberculosis), malignancies (lung cancer, metastatic cancer, lymphoma, mesothelioma), or other causes of inflammation (sarcoidosis, autoimmune diseases).
 
Determining the type of fluid present is important because it helps to shorten the list of possible causes of pleural effusion. Healthcare practitioners and laboratorians use an initial set of tests (cell count, protein, albumin, and lactate dehydrogenase (LD) level, and appearance of the fluid) to distinguish between transudates and exudates. If the fluid is an exudate, additional tests may be performed to further pinpoint the disease or condition causing pleuritis and/or pleural effusion. See the "The Test" tab for more on this.


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Porphyrins are a group of compounds defined by their chemical structure. These compounds are by-products of heme synthesis and are normally present at low concentrations in blood and other body fluids. Porphyrin tests measure porphyrins and their precursors in urine, blood, and/or stool.
Heme is an iron-containing pigment that is a component of hemoglobin and a number of other proteins. It consists of an organic portion (protoporphyrin) bound to an iron atom. The synthesis of heme is a step-by-step process that requires the sequential action of eight different enzymes. If there is a deficiency in one of these enzymes, the process is impeded and intermediate porphyrins such as uroporphyrin, coproporphyrin, and protoporphyrin build up in the body's fluids and tissues. The precursors that accumulate depend on which enzyme is deficient, and they can exert toxic effects.
Porphyrin tests are used to help diagnose and monitor a group of disorders called porphyrias. There are seven types of porphyria, and each one is associated with a different enzyme deficiency. Most porphyrias are inherited, the result of a gene mutation. They may be classified according to the signs and symptoms of the disease as neurological, cutaneous, or both.
The porphyrias that cause neurological symptoms present with acute attacks lasting days or weeks. Signs and symptoms during the attack include abdominal pain, constipation, confusion, hallucinations, and/or seizures. There are four neurologic porphyrias: acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), and the very rare ALA dehydratase deficiency porphyria (ADP). Some cases of VP and HCP may also have skin-related symptoms.
The cutaneous porphyrias are associated with photosensitivity that causes redness, swelling, a burning sensation, blistering, skin thickening, hyperpigmentation, and/or scarring. There are three cutaneous porphyrias: porphyria cutanea tarda (PCT), erythropoietic protoporphyria (EPP), and congenital erythropoietic porphyria (CEP). For more information about each disease, see the article on Porphyria.

To diagnose porphyrias, clinical laboratories measure porphyrins and their precursors in urine, blood, and/or stool. Testing may include measurement of one or more of the following:

1.Porphobilinogen (PBG), a porphyrin precursor, in urine
2.Delta-aminolevulinic acid (ALA), another porphyrin precursor, in urine
3.Porphyrins (uroporphyrin, coproporphyrin, and protoporphyrin) in urine, blood, or stool

Specialized laboratories may offer testing for one or more of the affected enzymes. The most commonly measured enzyme is porphobilinogen deaminase (PBG-D) in red blood cells, which tests for acute intermittent porphyria. A few laboratories offer genetic testing for specific gene mutations that cause one of the porphyrias, but this type of testing is not widely available.
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Potassium is an electrolyte that is vital to cell metabolism. It helps transport nutrients into cells and removes waste products out of cells. It is also important in muscle function, helping to transmit messages between nerves and muscles. This test measures the amount of potassium in the blood and/or urine.
Potassium, along with other electrolytes such as sodium, chloride, and bicarbonate (total CO2), helps regulate the amount of fluid in the body and maintains a stable acid-base balance. Potassium is present in all body fluids, but most potassium is found within the cells. Only a small amount is present in fluids outside the cells and in the liquid part of the blood (called serum or plasma).
We get most of the potassium we need from the foods that we eat and most people have an adequate intake of potassium. The body uses what it requires and the kidneys eliminate the rest in the urine. The body tries to keep the blood potassium level within a very narrow range. Levels are mainly controlled by aldosterone, a hormone produced by the adrenal glands in the kidneys.
Because the blood concentration of potassium is so small, minor changes can have significant consequences. If potassium levels are too low or too high, there can be serious health consequences; a person may be at risk for developing shock, respiratory failure, or heart rhythm disturbances. An abnormal potassium level can alter the function of the nerves and muscles; for example, the heart muscle may lose its ability to contract.


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Gout is a form of acute arthritis that causes severe pain and swelling in the joints. It most commonly affects the big toe, but may also affect the heel, ankle, hand, wrist, or elbow. It affects the spine often enough to be a factor in back pain. Gout usually comes on suddenly, goes away after 5-10 days, and can keep recurring. Gout is different from other forms of arthritis because it occurs when there are high levels of uric acid circulating in the blood, which can cause urate crystals to settle in the tissues of the joints.

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Inflammation of the soft tissue (gingiva) and abnormal loss of bone that surrounds the teeth and holds them in place. Gum disease is caused by toxins secreted by bacteria in "plaque" that accumulate over time along the gum line. This plaque is a mixture of food, saliva, and bacteria. Early symptoms of gum disease include gum bleeding without pain. Pain is a symptom of more advanced gum disease as the loss of bone around the teeth leads to the formation of gum pockets. Bacteria in these pockets cause gum infection, swelling, pain, and further bone destruction. Advanced gum disease can cause loss of otherwise healthy teeth.

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Your heart is an amazing organ. It continuously pumps oxygen and nutrient-rich blood throughout your body to sustain life. This fist-sized powerhouse beats (expands and contracts) 100,000 times per day, pumping five or six quarts of blood each minute, or about 2,000 gallons per day.

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Heartburn is a sensation of burning in the chest caused by stomach acid backing up into the esophagus (food pipe). The burning is usually in the upper and central part of the chest, just behind the sternum (breast bone). The burning can worsen or can be brought on by lying flat or on the right side. Pregnancy tends to aggravate heartburn.

Many people experience heartburn and there are a large number of over-the-counter (OTC) medications and home remedies available to treat heartburn or the symptoms of heartburn.


In most cases you will not need to see a health-care professional, except if the symptoms are frequent (several times a week) or severe.


If heartburn is severe or the pain is accompanied with additional symptoms such as shortness of breath, radiation into your arms or neck, you will need to see a doctor to distinguish these symptoms from more serious medical conditions such as a heart attack.

GERD (Gastroesophageal reflux disease) is a chronic and more serious form of heartburn.

If your heartburn symptoms occur more than twice a week you should see your health-care professional to make sure no serious problems are present.

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heel spur is a pointed bony outgrowth of the bone of the heel (the calcaneus bone). They are attributed to chronic local inflammation at the insertion of soft-tissue tendons or fascia in the area. Heel spurs can be located at the back of the heel or under the heel, beneath the sole of the foot. Heel spurs at the back of the heel are frequently associated with inflammation of the Achilles tendon (tendinitis) and cause tenderness and pain at the back of the heel made worse while pushing off the ball of the foot.

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An armpit lump usually refers to the enlargement of at least one of the lymph nodes under your arm. Lymph nodes are small, oval-shaped glands that are located throughout the body. They play an important role in your body’s immune system. The lump may feel small. In other cases, it may be extremely noticeable. Armpit lumps may be caused by cysts, infection, or irritation due to shaving or antiperspirant use. However, these lumps may also indicate a serious underlying health condition. 

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Hiccups are involuntary contractions of the diaphragm — the muscle that separates your chest from your abdomen and plays an important role in breathing. Each contraction is followed by a sudden closure of your vocal cords, which produces the characteristic "hic" sound.


Hiccups may result from a large meal, alcoholic or carbonated beverages or sudden excitement. In some cases, hiccups may be a sign of an underlying medical condition. For most people, a bout of hiccups usually lasts only a few minutes. Rarely, hiccups may persist for months. This can result in weight loss and exhaustion.

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Hypertension, also known as high or raised blood pressure, is a condition in which the blood vessels have persistently raised pressure. Blood is carried from the heart to all parts of the body in the vessels. Each time the heart beats, it pumps blood into the vessels. Blood pressure is created by the force of blood pushing against the walls of blood vessels (arteries) as it is pumped by the heart. The higher the pressure in blood vessels the harder the heart has to work in order to pump blood. If left uncontrolled, hypertension can lead to a heart attack, an enlargement of the heart and eventually heart failure. Blood vessels may develop bulges (aneurysms) and weak spots due to high pressure, making them more likely to clog and burst. The pressure in the blood vessels can also cause blood to leak out into the brain. This can cause a stroke. Hypertension can also lead to kidney failure, blindness, rupture of blood vessels and cognitive impairment.

Blood pressure is measured in millimeters of mercury (mm Hg) and is recorded as two numbers usually written one above the other. The upper number is the systolic blood pressure - the highest pressure in blood vessels when the heart contracts, or beats. The lower number is the diastolic blood pressure - the lowest pressure in blood vessels when the heart muscle relaxes. Normal adult blood pressure is defined as a systolic blood pressure of 120 mm Hg and a diastolic blood pressure of 80 mm Hg.

Hypertension is defined as a systolic blood pressure equal to or above 140 mm Hg and/or diastolic blood pressure equal to or above 90 mm Hg.

More than 1 in 5 adults worldwide have raised blood pressure – a condition that causes around half of all deaths from stroke and heart disease. Complications from hypertension account for 9.4 million deaths worldwide every year.

In nearly all high-income countries, widespread diagnosis and treatment with low-cost medication have led to a significant drop in the proportion of people with raised blood pressure as well as the average blood pressure across populations. This has contributed to a reduction in deaths from heart disease. For example, the prevalence of raised blood pressure in the WHO region of the Americas in 2014 was 18%, as compared to 31% in 1980.

In contrast, low-income countries have the highest prevalence of raised blood pressure. In the WHO African region, more than 30% of adults in many countries are estimated to have high blood pressure. This proportion is increasing and the average blood pressure levels in this region are much higher than global averages.

Many people with high blood pressure in developing countries are not aware of their disease. Those who are diagnosed may not have access to treatment and may not be able to successfully control their illness over the long term. It contributes to the burden of heart disease, stroke and kidney failure and premature mortality and disability.

Detection, treatment and control of hypertension is an important health priority worldwide.

 

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The III academic programme aims to deliver world class interdisciplinary research for children with infectious, immunological and inflammatory disease, children with life threatening respiratory disease, children in pain and critically ill children on intensive care.

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On the whole, your immune system does a remarkable job of defending you against disease-causing microorganisms. But sometimes it fails: A germ invades successfully and makes you sick. Is it possible to intervene in this process and boost your immune system? What if you improve your diet? Take certain vitamins or herbal preparations? Make other lifestyle changes in the hope of producing a near-perfect immune response?

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High blood pressure is also known as hypertension. Blood pressure is the amount of force exerted against the walls of the arteries as blood flows through them.


In the United States, approximately 85 million people have high blood pressure - about 1 in every 3 adults over 20, according to the American Heart Association (AHA).

The National Institutes of Health (NIH) estimate that about two-thirds of people over the age of 65 in the U.S. have high blood pressure.

If left untreated or uncontrolled, high blood pressure can cause many health problems. These conditions include heart failure, vision loss, stroke, and kidney disease.

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A normal menstrual cycle lasts 28 days, plus or minus seven days. Menstrual bleeding is considered irregular if it occurs more frequently than every 21 days or lasts longer than 8 days. Missed, early, or late periods are also considered signs of an irregular cycle.


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Jaundice is a term used to describe the yellowing of the skin and the whites of the eyes. It's caused by a build-up of a substance called bilirubin in the blood and body's tissues. Any condition that disrupts the movement of bilirubin from the blood to the liver and out of the body can cause jaundice. Bilirubin is a yellow pigment that is formed by the breakdown of dead red blood cells (RBC) in the liver. There are several ways that a build- up of bilirubin can occur:

If red blood cells broke down too early, the spleen gets overloaded and hence too much bilirubin is produced to be handled by the liver. Unprocessed bilirubin accumulates in the bloodstream and eventually the skin and eyes looks yellow. This condition is called hemolytic anemia. At times this condition is inherited. Hemolytic anemia may also occur as a side-effect of certain drugs.
Sometimes the trouble is in the liver cells. If there is a faulty uptake, processing or excretion of bilirubin it will result in an accumulation of bilirubin in the bloodstream. Newborn babies can be temporarily jaundiced because of lack of mature enzymes needed to process bilirubin. In adults, alcoholism is a common cause of damage to liver cells. Other toxins and certain drugs can also cause acute damage to the liver.
A blockage in the bile duct can also result in a build-up of fully processed bilirubin. This can spill over into the urine and cause it to become very dark. The blockage is most commonly caused by a gallstone.

 

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Keratosis pilaris (ker-uh-TOE-sis pih-LAIR-is) is a common, harmless skin condition that causes dry, rough patches and tiny bumps, usually on the upper arms, thighs, cheeks or buttocks. The bumps generally don't hurt or itch.Keratosis pilaris is often considered a variant of normal skin. It can't be cured or prevented. But you can treat it with moisturizers and prescription creams to help improve the appearance of the skin. The condition usually disappears by age 30.


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Our bodies produce several kinds of wastes, including sweat, carbon dioxide gas, feces (stool or poop), and urine (pee). These wastes leave the body in different ways. Sweat is released through pores in the skin. Water vapor and carbon dioxide are exhaled from the lungs. And undigested food materials are formed into feces in the intestines and excreted from the body as solid waste in bowel movements.

Urine, which is produced by the kidneys, contains the byproducts of metabolism — salts, toxins, and water — that end up in the blood. The kidneys and urinary tract (which includes the kidneys, ureters, bladder, and urethra) filter and eliminate these waste substances from our blood. Without the kidneys, waste products and toxins would soon build up in the blood to dangerous levels.


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His is the medical term for a definite kind of vaginal discharge that is most common during pregnancy as well as at additional times during the reproductive years. If an individual has leukorrhea, it may be a sticky as well as thick vaginal discharge that is yellow, green or white. It may vary with the menstrual cycle of the woman as her hormone levels change.

Discharges from the vagina are normally a sign of vaginal yeast infections, bacterial vaginosis, or sexually transmitted diseases. Leukorrhea may or may not be an indication of the presence of an infection, and it is not normally accompanied by any other symptoms or signs, such as itching, pain, irritation or burning, or redness of the tissue. Only a qualified medical professional can advise a woman whether there is an infection.

If a woman has any type vaginal discharge which is unusual during pregnancy or at any other time, she should always consult with her primary care physician before using any over-the-counter therapy or home remedies.


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Low blood pressure might seem desirable, and for some people, it causes no problems. However, for many people, abnormally low blood pressure (hypotension) can cause dizziness and fainting. In severe cases, low blood pressure can be life-threatening.

A blood pressure reading lower than 90 millimeters of mercury (mm Hg) for the top number (systolic) or 60 mm Hg for the bottom number (diastolic) is generally considered low blood pressure.

The causes of low blood pressure can range from dehydration to serious medical or surgical disorders. It's important to find out what's causing your low blood pressure so that it can be treated.


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lood is made up of several types of cells. These cells float in a liquid called plasma. The types of blood cells are:red blood cellswhite blood cellsplatelets, or thrombocytesWhen your skin is injured or broken, platelets clump together and form clots to stop the bleeding. When you don’t have enough platelets in your blood, your body cannot form clots.A low platelet count may also be called thrombocytopenia. This condition can range from mild to severe, depending on its underlying cause. For some, the symptoms can include severe bleeding and are possibly fatal if they’re not treated. Other people may not experience any symptoms.Typically, a low platelet count is the result of a medical condition, like leukemia, or certain drugs. The treatment usually addresses the condition causing the thrombocytopenia.


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Lung cancer is one of the most common types of cancer; it is also considered to be a severe form. It has affected a lot of people in society. So, this blog will ensure that you get all that you want to know about lung cancer simply. Here we will describe the factors that lead to lung cancer, the signs and symptoms of the disease, and how it can be prevented. 

We will also briefly note the various options for the treatment of lung cancer. Increasing one’s knowledge about lung cancer could help reduce the incidences or help prevent others from being affected. Many users question whether the doctors is lung cancer treatable as they think about how they would be able to dissect lung cancer. So we aim to increase awareness of patients at the stages when developing lung cancer. To determine how to diagnose this disease in its early stages and decrease the probability of developing this hazard. 


What is Lung Cancer?

Lung cancer develops in the lungs, which are vital organs in the process of breathing. The lungs are what assist in the processes of respiration since we breathe in oxygen while breathing out carbon dioxide. In lung cancer, there is an abnormal growth of cells in the lungs that can multiply beyond their normal turnover rate. These cells do not have orderly patterns regarding cell division. Instead, what they do is divide and enhance their numbers and become a mass that is termed a tumor. 


Since it develops from the lung tissue, the tumor can impede or even harm other sections of the lung as it grows larger. This makes it utterly cumbersome for the lungs to perform as required. In Individuals with lung disease, respiratory effort may be difficult, and oxygen may not be available to the body at optimum levels. Awareness of how lung cancer impacts the lungs can thus help in realizing its effects on health.


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Autism spectrum disorder (ASD) is a developmental disability  that can cause significant social, communication and behavioral challenges. There is often nothing about how people with ASD look that sets them apart from other people, but people with ASD may communicate, interact, behave, and learn in ways that are different from most other people. The learning, thinking, and problem-solving abilities of people with ASD can range from gifted to severely challenged. Some people with ASD need a lot of help in their daily lives; others need less.


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Lung transplantation or pulmonary transplantation is a surgical procedure in which a patient's diseased lungs are partially or totally replaced by lungs which come from a donor. Donor lungs can be retrieved from a living donor or a deceased donor. A living donor can only donate one lung lobe. With some lung diseases a recipient may only need to receive a single lung. With other lung diseases such as cystic fibrosis it is imperative that a recipient receive two lungs. While lung transplants carry certain associated risks, they can also extend life expectancy and enhance the quality of life for end-stage pulmonary patients.

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If you take good care of your lungs, they can last a lifetime. “The lungs are very durable if they’re not attacked from the outside,” says Norman H. Edelman, MD, chief medical officer of the American Lung Association (ALA). With a few exceptions, your lungs don’t get into trouble unless you get them into trouble, he says.However, chronic obstructive pulmonary disease (COPD) is the fourth-leading cause of death in the U.S. after heart disease, cancer, and stroke. Here are 12 things you can do to keep your lungs healthy as you age.


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Lung diseases are some of the most common medical conditions in the world. Tens of millions of people suffer from lung disease in the U.S. Smoking, infections, and genetics are responsible for most lung diseases.

The lungs are part of a complex apparatus, expanding and relaxing thousands of times each day to bring in oxygen and expel carbon dioxide. Lung disease can result from problems in any part of this system.

 

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If you’re here, you’ve probably just been diagnosed, or suspect you have Macular Degeneration, or someone you care about has just been diagnosed or suspects they have the disease.

This entire site is dedicated to information regarding Macular Degeneration, but this page will give you a quick general overview to get you oriented.

Macular Degeneration is the leading cause of vision loss, affecting more than 10 million Americans – more than cataracts and glaucoma combined.

Macular Degeneration is caused by the deterioration of the central portion of the retina, the inside back layer of the eye that records the images we see and sends them via the optic nerve from the eye to the brain. The retina’s central portion, known as the macula, is responsible for focusing central vision in the eye, and it controls our ability to read, drive a car, recognize faces or colors, and see objects in fine detail.

Illustrations of the anatomy of a normal human eye and loss of central vision:

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Menopause is defined as the absence of menstrual periods for 12 months. It is the time in a woman's life when the function of the ovaries ceases.The process of menopause does not occur overnight, but rather is a gradual process. This so-called perimenopausal transition period is a different experience for each woman.The average age of menopause is 51 years old, but menopause may occur as early as the 30s or as late as the 60s. There is no reliable lab test to predict when a woman will experience menopause.The age at which a woman starts having menstrual periods is not related to the age of menopause onset.

Symptoms of menopause can include abnormal vaginal bleeding, hot flashes, vaginal and urinary symptoms, and mood changes.Complications that women may develop after menopause include osteoporosis and heart disease.Treatments for menopause are customized for each woman.Treatments are directed toward alleviating uncomfortable or distressing symptoms.

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Heavy menstrual bleeding (called menorrhagia by health care professionals) is defined as soaking a pad and/or tampon every hour or less during each menstrual cycle. For many women, heavy menstrual bleeding is a huge obstacle to their lifestyles. Have you ever had to reschedule an activity around your menstrual period? Then, you know the toll it can take. You may not know that heavy bleeding can be more than a schedule buster. The heavy bleeding can also lead to iron-deficient anemia, the most common health-related threat of menorrhagia. While most cases of anemia are easily treated with oral iron supplements, sometimes the bleeding is so severe a woman's entire volume of blood drops, leading to shortness of breath, severe fatigue and heart palpitations that require hospitalization.


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Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects.The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases


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Cuts: A cut is an area of severed skin that has been penetrated with a sharp edge, such as a knife, a small tool or the edge of a sheet of paper (paper cuts are also painful). The wound will often bleed and have slightly dehiscent wound edges.Grazes or abrasions: A usually harmless abrasion of the upper skin layers that occurs after falling on knees, hands or elbows, or scratching over a rough surface with some skin coming off subsequently. Abrasions can be painful since the injury often extends to the many fine nerve endings subjacent to the skin.

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Minor skin wounds often occur as the result of unanticipated trauma and may include lacerations, abrasion (grazes), blisters and more serious wounds such as skin tears and bites. In many instances the skin may only require protection from further injury and can therefore be treated in the home with due regard for managing the risk of infection. In other cases the advice of a doctor is preferred, especially when the wound is deep and there may be damage to underlying structures such as nerves.

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Mosquito bites are the itchy bumps that appear after mosquitoes use their mouthparts to puncture your skin and feed on your blood. The bump usually clears up on its own in a few days. Occasionally a mosquito bite causes a large area of swelling, soreness and redness. This type of reaction, most common in children, is sometimes referred to as skeeter syndrome.

Bites from mosquitoes carrying certain viruses or parasites can cause severe illness. Infected mosquitoes in many parts of the world transmit West Nile virus to humans. Other mosquito-borne infections include yellow fever, malaria and some types of brain infection (encephalitis).

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Mouth ulcers — also known as canker sores — are normally small, painful lesions that develop in your mouth or at the base of your gums. They can make eating, drinking, and talking uncomfortable. Women, adolescents, and people with a family history of mouth ulcers are at higher risk for developing mouth ulcers.

Mouth ulcers aren’t contagious and usually go away within one to two weeks. However, if you get a canker sore that is large or extremely painful or if it lasts for a long time without healing, you should seek the advice of a doctor.

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An acute (sudden, shortlived) viral illness that usually presents with inflammation of the salivary glands, particularly the parotid glands. A child with mumps often looks like a chipmunk with a full mouth due to the swelling of the parotids (the salivary glands near the ears).

Mumps can also cause inflammation of other tissues, most frequently the covering and substance of the central nervous system (meningoencephalitis), the pancreas (pancreatitis) and, after adolescence, the ovary (oophoritis) and the testis (orchitis). The testis is particularly susceptible to damage from mumps; the damage can lead to infertility.

Together with the likes of measles and chickenpox, mumps was once considered one of the inevitable infectious diseases of childhood. Since a mumps vaccine became available in 1967, the incidence of mumps has declined in the U.S., but there are still many underimmunized populations (for example, more blacks than whites have not yet been immunized).

Treatment is with rest and non-aspirin pain relievers to ease pain in swollen areas. Rarely, mumps can cause a form of meningitis, in which case hospitalization may be needed. Prevention is by immunization with the vaccine.

The origin of the word mumps is not clear. It may have to do with the English usage, now obsolete, of "mump" to mean a grimace. More probably, mumps comes from a colder climate, Iceland, where mumpa meant to fill the mouth too full.

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An involuntarily and forcibly contracted muscle that does not relax. When we use the muscles such as those of our arms and legs that can voluntarily be controlled, they alternately contract and relax as we move our limbs. Muscles that support our head, neck, and trunk contract similarly in a synchronized fashion to maintain our posture. A muscle (or even a few fibers of a muscle) that involuntarily (without consciously willing it) contracts is called a "spasm." If the spasm is forceful and sustained, it becomes a cramp. Muscle cramps can last anywhere from a few seconds to a quarter of an hour, and occasionally longer. It is not uncommon for a cramp to recur multiple times until it finally goes away. The cramp may involve a part of a muscle, the entire muscle, or several muscles that usually act together, such as those that flex adjacent fingers. Some cramps involve the simultaneous contraction of muscles that ordinarily move body parts in opposite directions. Muscle cramps are very common and become increasingly frequent with age. Any muscle under voluntary control (skeletal muscle) can cramp. The legs and feet, and particularly the calf (the classic "charley horse"), are especially subject to cramps.

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Muscle aches, or myalgia, are extremely common. Almost everybody has experienced discomfort in their muscles at some point.

Because there is muscle tissue in nearly all parts of the body, this type of pain can be felt practically anywhere…

 

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If you have ever played sports, chances are you have experienced a muscle strain injury. Even if you aren't an athlete, muscle strains are some of the most common injuries; however, this type of injury is often confused with a sprain, so let's start by clarifying the difference.

A strain is an injury that affects the muscle or the tendon. The tendon is the tissue that connects muscle to bone.
A sprain is an injury that affects a ligament. A ligament is connective tissue joining bones together.
In this lesson, we're specifically concerned with muscle strains, which can come in different types: the muscle itself can partially or completely tear, or the tendons can partially or completely tear. In any case, it's painful. You may also hear a strain referred to as a pulled muscle.

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Bones give people shape. They hold the body upright, and also protect organs like the heart and the kidneys. They store the minerals calcium and phosphorus, and also contain bone marrow, where new blood cells are made.


There are different types of muscles and joints, each with different functions.


Skeletal muscle is muscle that you can consciously control. When your brain tells a muscle to contract, it shortens, pulling one bone towards another across a joint. Muscles work in pairs – when one shortens, a corresponding muscle lengthens. Physical activity maintains or increases the strength of skeletal muscles.


Smooth muscle sits in and around blood vessels and organs. You can’t consciously control smooth muscle. It helps regulate your blood pressure, airways and digestion.


The heart is made of special muscle called cardiac muscle. You can’t control it consciously. It contracts to make your heart beat.


Joints in the arms and legs are synovial joints which means they have fluid in them (synovial fluid) so bones can move over each other.


Joints in the spine and pelvis are cartilaginous joints – they provide more stability and less movement.


There are also fibrous joints that allow no movement at all – just stability. You have fibrous joints in your skull.

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One of a group of genetic diseases characterized by progressive weakness and degeneration of the skeletal or voluntary muscles which control movement. The muscles of the heart and some other involuntary muscles are also affected in some forms of muscular dystrophy, and a few forms involve other organs as well.

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Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.

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The University of Michigan C.S. Mott Children’s Hospital offers one of the nation’s leading treatment programs for infants, children and adolescents with neurological problems (problems affecting the nervous system).Our specialists treat children with brain and neurological conditions with a multidisciplinary approach led by physicians in our department of neurosurgery and our pediatric neurology service. Together with our colleagues in many other pediatric specialties throughout Mott Children’s Hospital, we provide our patients and their families with individualized treatment plans.The pediatric neurology service coordinates medical treatment and therapy for children with neurological conditions

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Numbness in one or both hands describes a loss of sensation or feeling in your hand or fingers. Often, hand numbness may be accompanied by other changes, such as a pins-and-needles sensation, burning or tingling. Your arm, hand or fingers may feel clumsy or weak.

Numbness can occur along a single nerve in one hand, or it may occur symmetrically in both hands.

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1. The Golden Rule

Do: Make sure you always (and we mean always) remove your makeup before hitting the sheets. The skin needs to breathe overnight. And makeup prevents that, as leaving it on overnight clogs the pores which may cause blemishes and/or blackheads. Don’t possess a makeup remover? Just put some olive oil on a cotton pad and gently massage the oil onto your face to get rid of the makeup and dirt.
Don’t: Forget that exfoliation is indispensable. At least once or twice a week, exfoliate your skin to remove the layers of dead skin, sure to leave you with a more healthy glow and brighter skin. You can also apply a paste of walnut in powder form with yogurt to exfoliate your skin, as the antioxidants present in walnuts help remove dirt and promote radiant skin.
 

Never forget to exfoliate your skin and remove the makeup before calling it a night.

2. Sun and Skin

Do: Apply sunscreen with SPF of at least 15 that blocks both UVA and UVB rays. Since a lifetime of sun exposure can cause wrinkles, age spots and other skin problems, you have to protect your skin from the sun. Make sure the label reads ‘noncomedogenic’ or ‘nonacnegenic’ so that the product does not tend to block pores.  

Don’t: Skip the sunscreen, whether it's cloudy or cold outside (no excuses). If you’re heading to a beach or around reflective surfaces like snow or ice, lather your skin up with some more sunscreen with SPF of at least 30.
 

Sunscreen with SPF of at least 15 that blocks both UVA and UVB rays.

3. You are What You Eat

Do: Keep a note of what you put on your plate. Eat fresh fruits, greens, sufficient protein and vitamins. A diet rich in vitamin C and low in fats and sugar promotes radiant skin. Consider a low-sugar diet, which can keep insulin levels down, allowing cells to maintain a healthy balance.

"Don’t: Eat spicy and fermented foods, salt, citrus fruits, fried food. Instead favour blander foods such as rice, oatmeal and applesauce”, advises American author and Ayurvedic physician, Vasant Lad, in The Complete Book of Ayurvedic Home Remedies.


Fresh fruits and greens is what healthy skin needs.

4. Sweat It Out!

Do: Exercise regularly. Running, jogging and yoga will give your body the necessary blood circulation, and also accelerate the cleansing process of your entire body. You will notice a glow on your face after working out. Racing against time? Just take a brisk walk around the block.

Don’t: Skip skincare before and after a workout. Apply a toner to help minimize oil production before heading out. Exfoliate after, and then apply shea butter or olive oil to moisturize the skin.
 
Running, jogging and yoga will accelerate the cleaning process of your body.

5. Beauty Sleep

Do: Try to sleep at least 8 hours every night. If you don’t get enough shut eye, your skin gets tired just like you - it sags and you get bags. So don’t risk it. You can also apply honey on your face twice or thrice a week to naturally soothe and heal your skin.

“Don’t: Forget to wash and moisturize your face before going to bed”, recommends Dr. Rahul Nagar, Dermatologist, Max Hospitals. “For dry skin, use milder cleansers that are free from alcohol. Apply lots of moisturizer, and avoid hot water as it dries out the skin excessively.”
 

Never forget to wash your face before sleeping and moisturize well.

6. H2O to The Rescue

Do: Hydrate yourself. Drink lots of water daily, at least 8 glasses if not more. Also, eats fruits and vegetables that have a high water content such as watermelon, cucumber, orange, strawberry, grapefruit and cantaloupe. Ayurvedic physician, Vasant Lad recommends to “drink water from a blue coloured bottle”, since it has a cooling effect.

Don’t: Ignore rose water. It helps prevent and reduce eye puffiness in the morning, maintains pH balance and naturally hydrates your skin if you spritz it on during the day.
 
Rose water maintains pH balance and  naturally hydrates the skin.

7. Goodbye Acne

“Do: Wash your face with warm water, three times a day, and gently massage your face in circular motions, ensuring that the cleanser contains alpha hydroxyl acid or beta hydroxyl acid. Face packs that contain multani mitti (fuller’s earth) work really well too. After cleansing, pat dry and apply a lotion which contains benzoyl peroxide”, suggests Dr. Zaheer Ahmed, Dermatologist, Max Hospitals. Benzoyl peroxide appears to be effective due to its antibacterial actions.

Don’t: Pop pimples because it can lead to more swelling, redness, and even scarring. Feel a pimple is on its way? Just clean the area with rose water, and place a chilled green tea bag for 10 minutes. Also, if you wear glasses or sunglasses, make sure you clean them frequently to keep oil from clogging the pores around your eyes and nose.
 
Never pop your pimples. Use rose water or chilled green tea bags.

8. Go Back to Your Roots

Do: Use Ayurvedic scrubs to nourish the skin, and help it breathe better. Luckily for you, everything you need is already in your kitchen. 2 tbsp chickpea flour, ½ tsp turmeric powder, a pinch of camphor and sandalwood with some rose water/milk/water is your perfect skincare pack. Yes, the secrets of beauty lies in ancient Ayurveda.

Don’t: Neglect the basics. Make Sudarshan Kriya your beauty mantra. Yes, it’s that easy. Just breathing right could rid you of spots and pimples. Nidhi Gureja, Art of Living, says “Sudarshan Kriya is a breathing technique which incorporates specific natural rhythms of the breath that harmonize the body, mind and emotions. This helps releasing accumulated stresses, and each individual’s experience is different.”
 
Sudarshan Kriya is a breathing technique which incorporates specific natural rhythms that helps in releasing accumulated stresses.

9. Spa Day Everyday?

Do: Have a regular skin care regimen. “For dry skin, use a fresh cherry mask. Apply the pulp of fresh cherries on your face before going to bed. Leave for 15 minutes and wash with lukewarm water”, adds American author Vasant Lad.

Don’t: Forget to pamper yourself. A gentle facial massage with oils could work wonders. Depending on your skin type, choose oils from mustard, coconut, almond or Kumkadi as they are excellent nourishing agents which help to get glowing skin. Better still – switch on some soothing instrumental music. After 20 minutes, what do you have? Beautiful skin and a relaxed you.

Pamper yourself occasionally with spa treatments.

10. Healthy Habits

Do: Take out time for yourself, and try to avoid stress as much as possible. Have you ever noticed that when you are stressed, you tend to break out more? This is because stress causes your body to produce cortisol and other hormones, making the skin more oily. Practice stress management techniques like breathing exercises, yoga and meditation. The more you meditate, the more you radiate.

Don’t: Neglect your jawline and facial muscles. For just 5 minutes a day, perform a few facial exercises. You can jut out your lower lip in such a way that wrinkles are created on the chin, then lower your chin to your chest. Another exercise that works wonders is to look up towards the ceiling and pout. It stretches out the muscles making the skin more firm. “18 till I die”, why not?
 
The more you meditate, the more you radiate.

You’re dressed to perfection, yet you need something to complete the look. Your smile! While we spend so much time and energy on honing our bodies and looks, we forget to express our inner joy and happiness. “Keeping a smile on your face will help maintain the tone of your facial muscles and skin. People may say you look 10 years younger than you are!”, adds the Ayurvedic physician, Vasant Lad.
   

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Oil pulling, also known as "kavala" or "gundusha," is an ancient Ayurvedic dental technique that involves swishing a tablespoon of oil in your mouth on an empty stomach for around 20 minutes. This action supposedly draws out toxins in your body, primarily to improve oral health but also to improve your overall health

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Don’t let the bed bugs bite

Despite their role in an adorable bedtime proverb, bed bugs are pesky little pests. They sneak into your bed, your furniture, even your carpet, and while you sleep or watch TV, they bite you. The next morning, you’re left wondering why you’re red and itchy.


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What are bed bugs?

Bed bugs are small, flat, oval-shaped insects. They do not have wings and rely on humans to carry them from one place to the next. Bed bugs are a reddish-brown color and can be between 1 and 7 millimeters. They feed on blood from humans or animals, and they’re most active at night, feeding on their victims while they sleep.

What do bed bug bites look like?

Some people will not experience a reaction to a bed bug bite at all. Those that do experience symptoms of a bite are likely to experience one or more of the following:


    a bite with a red, swollen area and a dark red center
    bites in a line or grouped together in a small area
    blisters or hives at the bite site


Bites can happen anywhere on the body. Most commonly they occur on areas of skin that are exposed while sleeping, such as the face, arms, legs, and hands.


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Painful urination (dysuria) is discomfort or burning with urination, usually felt in the tube that carries urine out of your bladder (urethra) or the area surrounding your genitals (perineum).

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Can you treat and eliminate the bed bugs on your own? Bed bugs are challenging pests to get rid of, since they hide so well and reproduce so quickly. In addition, the egg stage is resistant to many forms of treatment, so a single attempt may not be sufficient to complete the job.

Treating bed bugs is complex. Your likelihood of success depends on many factors, including:
Person inspecting furniture for pest infestation

    Extent of the infestation.
    Site-specific challenges.
        Clutter.
        Neighbors with infestations.
        Ability of all of the residents to participate.

Achieving complete control can take weeks to months, depending on the nature and extent of the infestation, and everyone will need to cooperate and do their part.

Before starting, you should lay out all of the steps on a calendar. The following steps will help you begin:

    Identify the problem
    Develop a strategy
    Keep the infestation from expanding
    Prepare for treatment
    Kill the bed bugs
    Evaluate and prevent


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Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli. Typically symptoms include some combination of productive or dry cough, chest pain, fever, and trouble breathing. Severity is variable.

Pneumonia is usually caused by infection with viruses or bacteria and less commonly by other microorganisms, certain medications and conditions such as autoimmune diseases. Risk factors include other lung diseases such as cystic fibrosis, COPD, and asthma, diabetes, heart failure, a history of smoking, a poor ability to cough such as following a stroke, or a weak immune system. Diagnosis is often based on the symptoms and physical examination. Chest X-ray, blood tests, and culture of the sputum may help confirm the diagnosis. The disease may be classified by where it was acquired with community, hospital, or health care associated pneumonia.
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Postpartum depression (PPD), also called postnatal depression, is a type of mood disorder associated with childbirth, which can affect both sexes. Symptoms may include extreme sadness, low energy, anxiety, crying episodes, irritability, and changes in sleeping or eating patterns. Onset is typically between one week and one month following childbirth. PPD can also negatively affect the person's child.

While the exact cause of PPD is unclear, the cause is believed to be a combination of physical and emotional factors. These may include factors such as hormonal changes and sleep deprivation. Risk factors include prior episodes of postpartum depression, bipolar disorder, a family history of depression, psychological stress, complications of childbirth, lack of support, or a drug use disorder. Diagnosis is based on a person's symptoms. While most women experience a brief period of worry or unhappiness after delivery, postpartum depression should be suspected when symptoms are severe and last over two weeks.
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The premature graying problem is largely genetic. Hair follicles contain pigment cells that produce melanin, which gives your tresses their color. When your body stops generating melanin, hair presents itself as gray, white, or silver

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Premenstrual syndrome (PMS) refers to physical and emotional symptoms that occur in the one to two weeks before a woman's period. Symptoms often vary between women and resolve around the start of bleeding. Common symptoms include acne, tender breasts, bloating, feeling tired, irritability, and mood changes. Often symptoms are present for around six days. A woman's pattern of symptoms may change over time. Symptoms do not occur during pregnancy or following menopause.

Diagnosis requires a consistent pattern of emotional and physical symptoms occurring after ovulation and before menstruation to a degree that interferes with normal life. Emotional symptoms must not be present during the initial part of the menstrual cycle. A daily list of symptoms over a few months may help in diagnosis. Other disorders that cause similar symptoms need to be excluded before a diagnosis is made.

The cause of PMS is unknown. Some symptoms may be worsened by a high-salt diet, alcohol, or caffeine. The underlying mechanism is believed to involve changes in hormone levels. Reducing salt, caffeine, and stress along with increasing exercise is typically all that is recommended in those with mild symptoms. Calcium and vitamin D supplementation may be useful in some. Anti-inflammatory drugs such as naproxen may help with physical symptoms. In those with more significant symptoms birth control pills or the diuretic spironolactone may be useful.

Up to 80% women report having some symptoms prior to menstruation. These symptoms qualify as PMS in 20 to 30% of pre-menopausal women. Premenstrual dysphoric disorder (PMDD) is a more severe form of PMS that has greater psychological symptoms. PMDD affects three to eight percent of pre-menopausal women. Antidepressant medication of the selective serotonin reuptake inhibitors class may be used in addition to usual measures for in PMDD.
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Premenstrual syndrome (PMS) has a wide variety of symptoms, including mood swings, tender breasts, food cravings, fatigue, irritability and depression. It's estimated that as many as 3 of every 4 menstruating women have experienced some form of premenstrual syndrome.

Symptoms tend to recur in a predictable pattern. But the physical and emotional changes you experience with premenstrual syndrome may vary from just slightly noticeable all the way to intense.

Still, you don't have to let these problems control your life. Treatments and lifestyle adjustments can help you reduce or manage the signs and symptoms of premenstrual syndrome

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Periorbital puffiness, also known as "puffy eyes", or swelling around the eyes, is the appearance of swelling in the tissues around the eyes, called the orbits. It is almost exclusively caused by fluid buildup around the eyes, or periorbital edema. Minor puffiness usually detectable below the eyes only (although at times they could be present all around) is often called eye bags. Such transient puffiness is distinct from the age related and gradual increase in the size of the fat pad lying below the lower eyelids (suborbicularis oculi fat – "SOOF") which can also be colloquially referred to as eye bags.
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Pulmonary fibrosis (literally "scarring of the lungs") is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems. Scar formation, the accumulation of excess fibrous connective tissue (the process called fibrosis), leads to thickening of the walls, and causes reduced oxygen supply in the blood. As a consequence patients suffer from perpetual shortness of breath.

In some patients the specific cause of the disease can be diagnosed, but in others the probable cause cannot be determined, a condition called idiopathic pulmonary fibrosis. There is no known cure for the scars and damage in the lung due to pulmonary fibrosis.
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Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs. Symptoms include shortness of breath, syncope, tiredness, chest pain, swelling of the legs, and a fast heartbeat. The condition may make it difficult to exercise. Onset is typically gradual.

The cause is often unknown. Risk factors include a family history, prior blood clots in the lungs, HIV/AIDS, sickle cell disease, cocaine use, COPD, sleep apnea, living at high altitudes, and problems with the mitral valve. The underlying mechanism typically involves inflammation of the arteries in the lungs. Diagnosis involves first ruling out other potential causes.

There is no cure. Treatment depends on the type of disease. A number of supportive measures such as oxygen therapy, diuretics, and medications to inhibit clotting may be used. Medications specifically for the condition include epoprostenol, treprostinil, iloprost, bosentan, ambrisentan, macitentan, and sildenafil. A lung transplant may be an option in certain cases.

While the exact frequency of the condition is unknown, it is estimated that about 1,000 new cases occur a year in the United States. Females are more often affected than males. Onset is typically between 20 and 60 years of age. It was first identified by Ernst von Romberg in 1891.
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You eat organic almost exclusively and try to steer clear of anything made of plastic (especially The 4 Most Dangerous Types Of Plastic). But there’s just one unhealthy habit you can’t shake: smoking.

You may even tell yourself that the “natural” tobacco you use isn’t as bad for you, but even without the additives found in common cigarette brands, tobacco smoke contains a panoply of dangerous chemicals such as carbon monoxide and dozens of other known carcinogens.

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A breast rash describes redness and irritation of the skin on your breast. A breast rash can also be itchy, scaly, painful or blistered.

Other terms used to describe a breast rash include dermatitis and hives.

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Dirt, bacteria, fungus, and other germs can get trapped inside your belly button and start to multiply. This can cause an infection. You might notice white, yellow, brown, or bloody discharge seeping out of your belly button. That discharge might also have an unpleasant smell. Here are a few of the causes of belly button discharge, and how to treat them.


Causes of belly button discharge include infections, surgery, and cysts.

Bacterial infection

The average belly button is home to nearly 70 different types of bacteria. If you don’t clean the area well, these bacteria could cause an infection. Piercings in your navel can also get infected.

Bacterial infections cause a yellow or green, foul-smelling discharge. You can also have swelling, pain, and a scab around your belly button.


Yeast infection

Candidiasis is a yeast infection caused by Candida, a type of yeast that typically grows in damp, dark areas of the body. It can occur between skin folds, such as in your groin area and under your arms. Yeast can also take up residence in your belly button, especially if you don’t keep it clean and dry.

Candidiasis in your belly button causes a red, itchy rash on your navel and may also cause a thick, white discharge.
Diabetes

People with diabetes are more likely to get yeast infections. This is because yeast feeds on sugar, and high blood sugar is a hallmark of poorly treated diabetes. A study of Brazilian woman showed that women with diabetes were more prone to vaginal yeast infections than women who didn’t have diabetes.

Other studies suggest that other forms of yeast infections, including yeast infections in the belly button, may be more common among people with diabetes.


Surgery

If you’ve recently had abdominal surgery, such as hernia repair, you might notice pus draining from your belly button. If this happens, call your doctor. It could be a sign of an infection that needs to be treated.

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Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which spasm of arteries cause episodes of reduced blood flow. Typically the fingers, and less commonly the toes, are involved. Rarely, the nose, ears, or lips are affected. The episodes result in the affected part turning white and then blue. Often, there is numbness or pain. As blood flow returns, the area turns red and burns. The episodes typically last minutes, but can last up to several hours.

Episodes are often triggered by cold or emotional stress. There are two main types: primary Raynaud's, when the cause is unknown, and secondary Raynaud's, which occurs as a result of another condition. Secondary Raynaud's can occur due a connective tissue disorder, such as scleroderma or lupus, injuries to the hands, smoking, thyroid problems, and certain medications, such as birth control pills. Diagnosis is typically based on the symptoms.
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Razor burn can affect any person who shaves part of their body. If you’ve ever had a red rash after shaving, you were likely experiencing razor burn.

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Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. The disease may also affect other parts of the body. This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. Fever and low energy may also be present. Often, symptoms come on gradually over weeks to months.

While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. The underlying mechanism involves the body's immune system attacking the joints. This results in inflammation and thickening of the joint capsule. It also affects the underlying bone and cartilage. The diagnosis is made mostly on the basis of a person's signs and symptoms. X-rays and laboratory testing may support a diagnosis or exclude other diseases with similar symptoms. Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others.
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Rhinorrhea or rhinorrhoea is a condition where the nasal cavity is filled with a significant amount of mucus fluid. The condition, commonly known as a runny nose, occurs relatively frequently. Rhinorrhea is a common symptom of allergies (hay fever) or certain diseases, such as the common cold. It can be a side effect of crying, exposure to cold temperatures, cocaine abuse or withdrawal, such as from opioids like methadone. Treatment for rhinorrhea is not usually necessary, but there are a number of medical treatments and preventive techniques available.
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Fibrous tissue that forms when normal tissue is destroyed by disease, injury, or surgery. For example, scar tissue forms when a wound heals after a cut, sore, burn, or other skin condition, or when an incision (cut) is made into the skin during surgery. It may also form inside the body when certain conditions, such as cirrhosis, cause normal tissue to become fibrous tissue.

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Gastroesophageal reflux disease (GERD), also known as acid reflux, is a long-term condition where stomach contents come back up into the esophagus resulting in either symptoms or complications.Symptoms include the taste of acid in the back of the mouth, heartburn, bad breath, chest pain, vomiting, breathing problems, and wearing away of the teeth. Complications include esophagitis, esophageal strictures, and Barrett's esophagus.

Risk factors include obesity, pregnancy, smoking, hiatus hernia, and taking certain medicines. Medications involved include antihistamines, calcium channel blockers, antidepressants, and sleeping medication. It is due to poor closure of the lower esophageal sphincter (the junction between the stomach and the esophagus).Diagnosis among those who do not improve with simpler measures may involve gastroscopy, upper GI series, esophageal pH monitoring, or esophageal manometry.

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Shoulder problems including pain, are one of the more common reasons for physician visits for musculoskeletal symptoms. The shoulder is the most movable joint in the body. However, it is an unstable joint because of the range of motion allowed. This instability increases the likelihood of joint injury, often leading to a degenerative process in which tissues break down and no longer function well.

Shoulder pain may be localized or may be referred to areas around the shoulder or down the arm. Other regions within the body (such as gallbladder, liver, or heart disease, or disease of the cervical spine of the neck) also may generate pain that the brain may interpret as arising from the shoulder.
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It's inflammation or swelling of your sinuses. Normally they're filled with air. When they become blocked and filled with fluid, bacteria can grow there and cause infection. The result: a sinus infection. You may hear your doctor refer to it as sinusitis. 

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Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms. Common signs and symptoms include thick nasal mucus, a plugged nose, and pain in the face. Other signs and symptoms may include fever, headaches, poor sense of smell, sore throat, and cough. The cough is often worse at night. Serious complications are rare. It is defined as acute rhinosinusitis (ARS) if it lasts less than 4 weeks, and as chronic rhinosinusitis (CRS) if it lasts for more than 12 weeks.

Sinusitis can be caused by infection, allergies, air pollution, or structural problems in the nose. Most cases are caused by a viral infection. A bacterial infection may be present if symptoms last more than ten days or if a person worsens after starting to improve. Recurrent episodes are more likely in people with asthma, cystic fibrosis, and poor immune function. X-rays are not typically needed unless complications are suspected. In chronic cases confirmatory testing is recommended by either direct visualization or computed tomography.
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Skin rejuvenation helps rectify skin irregularities on the face and elsewhere on the body. La belle's Skin rejuvenation treatments have been developed considering the general needs and the various problems that could possibly affect the skin. We aim to help restore and promote the wellness of your skin and spirit. Our experts suggest the appropriate skin rejuvenation treatments after examining your skin type and identifying your requirement. Facial rejuvenation is a treatment aims to restore a youthful appearance to the human face cosmetically and can be carried out by surgical and/or non-surgical options

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A sore tongue is any pain or discomfort of all or a part of the tongue. Pain is a sensation triggered by the nervous system in response to tissue inflammation or damage. If you have a sore tongue, you may feel a dull, stabbing, shooting, burning, or pins-and-needles sensation.

The tongue is composed mainly of muscle. A sore or painful tongue can result from infection, inflammation, trauma, malignancy and other abnormal processes of the tissues of the tongue. One common condition that causes a sore tongue is glossitis, an inflammation of the tongue that also results in tongue swelling and discoloration that is caused by irritants, infection or other disorders.

Depending on the cause, a sore tongue can begin suddenly and resolve on its own, such as after biting your tongue. Tongue pain or soreness that develops over time and worsens may be a sign of a more serious condition, such as cancer.

In some cases, a sore tongue can be a sign of a serious or life-threatening disease or condition, such as an anaphylactic reaction. If you are experiencing difficulty breathing, swelling of the tongue, mouth or face, or a change in consciousness,

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Gastroenteritis, also known as infectious diarrhea, is inflammation of the gastrointestinal tract that involves the stomach and small intestine. Signs and symptoms include some combination of diarrhea, vomiting, and abdominal pain. Fever, lack of energy, and dehydration may also occur. This typically lasts less than two weeks. It is unrelated to influenza though it has been called the "stomach flu".

Gastroenteritis can be due to infections by viruses, bacteria, parasites, and fungus. The most common cause is viruses. In children rotavirus is the most common cause of severe disease. In adults, norovirus and Campylobacter are common. Transmission may occur due to eating improperly prepared foods, drinking contaminated water, or through close contact with an individual who is infected. Testing to confirm the diagnosis is typically not needed.
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Stomach ulcers, which are also known as gastric ulcers, are painful sores in the stomach lining. Stomach ulcers are a type of peptic ulcer disease. Peptic ulcers are any ulcers that affect both the stomach and small intestines.


Stomach ulcers occur when the thick layer of mucus that protects your stomach from digestive juices is reduced. This allows the digestive acids to eat away at the tissues that line the stomach, causing an ulcer.


Stomach ulcers may be easily cured, but they can become severe without proper treatment.

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You're not ready to have a child yet but unsure if you want to use birth control pills or get a contraceptive injection. Have you considered using herbal birth control yet?

Several herbs are effective in preventing pregnancy. The best part? They're all-natural, so you don't have to worry about harsh chemicals or side effects.

This post will discuss the most effective herbal birth control methods and how to use them.

Herbal Birth Control: What is it??

Herbal birth control is a method of avoiding pregnancy that uses natural herbs. These herbs work to prevent the woman from ovulating or releasing eggs. You can choose the best birth control herbs from a variety of options with the assistance of your doctor.


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The presence of increased secretions and mucus in the nasal passages, most commonly arising as a result of a common cold, allergic reaction, or inflammation or infection of the paranasal sinuses (sinus infection).

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Sun tanning or simply tanning is the process whereby skin color is darkened or tanned. It is most often a result of exposure to ultraviolet (UV) radiation from sunlight or from artificial sources, such as a tanning lamp found in indoor tanning beds. People who deliberately tan their skin by exposure to the sun engage in a passive recreational activity of sun bathing. Some people use chemical products which can produce a tanning effect without exposure to ultraviolet radiation, known as sunless tanning.

Moderate exposure to the sun contributes to the production of melanin and vitamin D by the body, but excessive exposure to ultraviolet rays has negative health effects, including sunburn and increased risk of skin cancer, as well as depressed immune system function and accelerated aging of the skin. Some people tan or sunburn more easily than others. This may be the result of different skin types and natural skin color, and these may be a result of genetics.

Several cases of tanning addiction have been reported by medical researchers. Though the mechanism by which tanning addiction occurs is unknown, some evidence indicates that the release of endorphins during the tanning process causes the pleasurable effects that underlie the addiction.
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Inflammation and erythema of the skin, often with blistering, caused by overexposure to the ultraviolet rays of direct sunlight.

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Sunburn is a form of radiation burn that affects living tissue, such as skin, that results from an overexposure to ultraviolet (UV) radiation, commonly from the sun. Common symptoms in humans and other animals include red or reddish skin that is hot to the touch, pain, general fatigue, and mild dizziness. An excess of UV radiation can be life-threatening in extreme cases. Exposure of the skin to lesser amounts of UV radiation will often produce a suntan.


Excessive UV radiation is the leading cause of primarily non-malignant skin tumors. Sunscreen is widely agreed to prevent sunburn and some types of skin cancer. Clothing, including hats, is considered the preferred skin protection method. Moderate sun tanning without burning can also prevent subsequent sunburn, as it increases the amount of melanin, a photoprotective pigment that is the skin's natural defense against overexposure. Importantly, both sunburn and the increase in melanin production are triggered by direct DNA damage. When the skin cells' DNA is overly damaged by UV radiation, type I cell-death is triggered and the skin is replaced.

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Sanskrit: सूर्यनमस्कार IPA: Sun Salutation, is a Yoga warm up routine based on a sequence of gracefully linked asanas. The nomenclature refers to the symbolism of Sun as the soul and the source of all life. It was developed in the 20th century.

A yogi may develop a personalized yoga warm up routine as surya-namaskar to precede his or her asana practice.
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Swine influenza is an infection caused by any one of several types of swine influenza viruses. Swine influenza virus (SIV) or swine-origin influenza virus (S-OIV) is any strain of the influenza family of viruses that is endemic in pigs. As of 2009, the known SIV strains include influenza C and the subtypes of influenza A known as H1N1, H1N2, H2N1, H911,H3N1, H3N2, and H2N3.

The Swine flu was initially seen in humans in Mexico in 2009, where the strand of the particular virus was a marriage of 3 types of strands. Six of the genes are very similar to the H1N2 influenza virus that was found in pigs around 2000.

Swine influenza virus is common throughout pig populations worldwide. Transmission of the virus from pigs to humans is not common and does not always lead to human flu, often resulting only in the production of antibodies in the blood. If transmission does cause human flu, it is called zoonotic swine flu. People with regular exposure to pigs are at increased risk of swine flu infection.
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Swine flu (swine influenza) is a respiratory disease caused by viruses (influenza viruses) that infect the respiratory tract of pigs, resulting in nasal secretions, a barking cough, decreased appetite, and listless behavior. Swine flu produces most of the same symptoms in pigs as human flu produces in people. Swine flu can last about one to two weeks in pigs that survive. Swine influenza virus was first isolated from pigs in 1930 in the U.S. and has been recognized by pork producers and veterinarians to cause infections in pigs worldwide. In a number of instances, people have developed the swine flu infection when they are closely associated with pigs (for example, farmers, pork processors), and likewise, pig populations have occasionally been infected with the human flu infection. In most instances, the cross-species infections (swine virus to man; human flu virus to pigs) have remained in local areas and have not caused national or worldwide infections in either pigs or humans. Unfortunately, this cross-species situation with influenza viruses has had the potential to change. Investigators decided the 2009 so-called "swine flu" strain, first seen in Mexico, should be termed novel H1N1 flu since it was mainly found infecting people and exhibits two main surface antigens, H1 (hemagglutinin type 1) and N1 (neuraminidase type1). The eight RNA strands from novel H1N1 flu have one strand derived from human flu strains, two from avian (bird) strains, and five from swine strains

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Tooth decay and gum disease occur in both children and adults. Yet, when you keep your teeth and gums healthy and strong, these problems are preventable. Four components are crucial to your plan for strong teeth and healthy gums: a healthy diet, good oral hygiene, use of fluorides and regular professional cleanings. Not only will this help protect you against oral disease, but it can also help you to keep your teeth for a lifetime.

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Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.

Not all lumps on the testicles are tumors, and not all tumors are cancer. There are many other conditions, such as testicular microlithiasis, epididymal cysts, and appendix testis (hydatid of Morgagni), which may be painful but are non-cancerous.

Testicular cancer has one of the highest cure rates of all cancers with an average five-year survival rate of 95%. If the cancer has not spread outside the testicle, the 5-year survival is 99% while if it has grown into nearby structures or has spread to nearby lymph nodes, the rate is 96% and if it has spread to organs or lymph nodes away from the testicles, the 5-year survival is around 74%. Even for the relatively few cases in which cancer has spread widely, chemotherapy offers a cure rate of at least 80%.

Globally testicular cancer resulted in 8,300 deaths in 2013 up from 7,000 deaths in 1990. In the United States, about 8,000 cases are diagnosed a year. In the UK, approximately 2,000 people are diagnosed each year,over a lifetime, the risk of testicular cancer is roughly 1 in 200 (0.5%). It is the most common cancer in males aged 20–39 years, the period when it is most common to start, and is rarely seen before the age of 15 years.
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Testosterone is the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. In addition, testosterone is involved in health and well-being, and the prevention of osteoporosis. Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss.

Testosterone is also used as a medication to treat male hypogonadism and certain types of breast cancer. Since testosterone levels gradually decrease as men age, synthetic testosterone is sometimes prescribed to older men to counteract this deficiency.

Testosterone is a steroid from the androstane class containing a keto and hydroxyl groups at the three and seventeen positions respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites. It exerts its action through binding to and activation of the androgen receptor.
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Tinea cruris, also known as crotch itch, crotch rot, Dhobi itch, eczema marginatum, gym itch, jock itch, jock rot, scrot rot and ringworm of the groin 303 is a dermatophyte fungal infection of the groin region in any sex, though more often seen in males.
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Tinnitus is the hearing of sound when no external sound is present. While often described as a ringing, it may also sound like a clicking, hiss or roaring. Rarely, unclear voices or music are heard. The sound may be soft or loud, low pitched or high pitched and appear to be coming from one ear or both. Most of the time, it comes on gradually. In some people, the sound causes depression or anxiety and can interfere with concentration.

Tinnitus is not a disease but a symptom that can result from a number of underlying causes. One of the most common causes is noise-induced hearing loss. Other causes include: ear infections, disease of the heart or blood vessels, Ménière's disease, brain tumors, emotional stress, exposure to certain medications, a previous head injury, and earwax. It is more common in those with depression.
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Onychomycosis, also known as tinea unguium, is a fungal infection of the nail. This condition may affect toenails or fingernails, but toenail infections are particularly common.

Treatment may be based on the signs. Treatment may be with the medication terbinafine.

It occurs in about 10 percent of the adult population. It is the most common disease of the nails and constitutes about half of all nail abnormalities.
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A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from tri- and glyceride). Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils.

There are many different types of triglyceride, with the main division between saturated and unsaturated types. Saturated fats are "saturated" with hydrogen – all available places where hydrogen atoms could be bonded to carbon atoms are occupied. These have a higher melting point and are more likely to be solid at room temperature. Unsaturated fats have double bonds between some of the carbon atoms, reducing the number of places where hydrogen atoms can bond to carbon atoms. These have a lower melting point and are more likely to be liquid at room temperature.
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Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB). Tuberculosis generally affects the lungs, but can also affect other parts of the body. Most infections do not have symptoms, in which case it is known as latent tuberculosis. About 10% of latent infections progress to active disease which, if left untreated, kills about half of those infected. The classic symptoms of active TB are a chronic cough with blood-containing sputum, fever, night sweats, and weight loss. The historical term "consumption" came about due to the weight loss. Infection of other organs can cause a wide range of symptoms.

Tuberculosis is spread through the air when people who have active TB in their lungs cough, spit, speak, or sneeze. People with latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke. Diagnosis of active TB is based on chest X-rays, as well as microscopic examination and culture of body fluids. Diagnosis of latent TB relies on the tuberculin skin test (TST) or blood tests.
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Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary symptom of active disease is abdominal pain and diarrhea mixed with blood. Weight loss, fever, and anemia may also occur. Often symptoms come on slowly and can range from mild to severe. Symptoms typically occur intermittently with periods of no symptoms between flares. Complications may include megacolon, inflammation of the eye, joints, or liver, and colon cancer.

The cause of UC is unknown. Theories involve immune system dysfunction, genetics, changes in the normal gut bacteria, and environmental factors. Rates tend to be higher in the developed world with some proposing this to be the result of less exposure to intestinal infections, or a Western diet and lifestyle. The removal of the appendix at an early age may be protective. Diagnosis is typically by colonoscopy with tissue biopsies. It is a kind of inflammatory bowel disease (IBD) along with Crohn's disease and microscopic colitis.
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Indigestion, also known as dyspepsia, is a condition of impaired digestion. Symptoms may include upper abdominal fullness, heartburn, nausea, belching, or upper abdominal pain. People may also experience feeling full earlier than expected when eating. Dyspepsia is a common problem and is frequently caused by gastroesophageal reflux disease (GERD) or gastritis. In a small minority of cases it may be the first symptom of peptic ulcer disease (an ulcer of the stomach or duodenum) and, occasionally, cancer. Hence, unexplained newly onset dyspepsia in people over 55 or the presence of other alarming symptoms may require further investigations.

Functional indigestion (previously called nonulcer dyspepsia) is indigestion "without evidence of an organic disease that is likely to explain the symptoms". Functional indigestion is estimated to affect about 15% of the general population in western countries.
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Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions including diabetes and the formation of ammonium acid urate kidney stones.
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Urinary incontinence (UI), also known as involuntary urination, is any leakage of urine. It is a common and distressing problem, which may have a large impact on quality of life. It is twice as common in women as in men. Pregnancy, childbirth, and menopause are major risk factors. It has been identified as an important issue in geriatric health care. Urinary incontinence is often a result of an underlying medical condition but is under-reported to medical practitioners. Enuresis is often used to refer to urinary incontinence primarily in children, such as nocturnal enuresis (bed wetting).

There are four main types of incontinence:

Urge incontinence due to an overactive bladder
Stress incontinence due to poor closure of the bladder
Overflow incontinence due to either poor bladder contraction or blockage of the urethra
Functional incontinence due to medications or health problems making it difficult to reach the bathroom
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A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as kidney infection (pyelonephritis). Symptoms from a lower urinary tract include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. Symptoms of a kidney infection include fever and flank pain usually in addition to the symptoms of a lower UTI. Rarely the urine may appear bloody. In the very old and the very young, symptoms may be vague or non-specific.

The most common cause of infection is Escherichia coli, though other bacteria or fungi may rarely be the cause. Risk factors include female anatomy, sexual intercourse, diabetes, obesity, and family history. Although sexual intercourse is a risk factor, UTIs are not classified as sexually transmitted infections (STIs). Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection. Diagnosis in young healthy women can be based on symptoms alone. In those with vague symptoms, diagnosis can be difficult because bacteria may be present without there being an infection. In complicated cases or if treatment fails, a urine culture may be useful.
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Itching or irritation anywhere on the body can cause discomfort. But when it occurs in an area as sensitive as the vagina and vulva (the labia, clitoris, and vaginal opening), it can be especially uncomfortable. Most genital itching and irritation isn't a major concern. But because they can be symptoms of an infection, it's always a good idea to call your health care provider.

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Morning sickness, also called nausea and vomiting of pregnancy (NVP), is a symptom of pregnancy that involves nausea or vomiting. Despite the name, nausea or vomiting can occur at any time during the day. Typically these symptoms occur between the 4th and 16th week of pregnancy. About 10% of women still have symptoms after the 20th week of pregnancy. A severe form of the condition is known as hyperemesis gravidarum and results in weight loss.

The cause of morning sickness is unknown but may be related to changing levels of the hormone human chorionic gonadotrophin. Some have proposed that it may be useful from an evolutionary point of view. Diagnosis should only occur after other possible causes have been ruled out. Abdominal pain, fever, or headaches are typically not present in morning sickness.

Taking prenatal vitamins before pregnancy may decrease the risk. Specific treatment other than a bland diet may not be required for mild cases. If treatment is used the combination of doxylamine and pyridoxine is recommended initially. There is limited evidence that ginger may be useful. For severe cases that have not improved with other measures methylprednisolone may be tried. Tube feeding may be required in women who are losing weight.

Morning sickness affects about 70-80% of all pregnant women to some extent. About 60% of women have vomiting. Hyperemesis gravidarum occurs in about 1.6% of pregnancies. Morning sickness can negatively affect quality of life, result in decreased ability to work while pregnant, and result in health care expenses. Generally mild to moderate cases have no effect on the baby. Most severe cases also have normal outcomes. Some women choose to have an abortion due to the severity of symptoms. Complications such as Wernicke encephalopathy or esophageal rupture may occur but are very rare.
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Tongue diseases can be congenital or acquired, and are multiple in number. Considered according to a surgical sieve, some example conditions which can involve the tongue are discussed below. Glossitis is a general term for tongue inflammation, which can have various etiologies, e.g. infection.
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Blisters is very painful to experience blister over the tongue as this does not allow us to have our food in a comfortable way. Even it becomes very hard to get the taste of every food we intake as the pain becomes intolerable. The burning sensation can develop if you have unmindfully eaten up a hot food or a hot drink that imperatively have affected the outer layer of the tongue.

The first thing which you should do is spilt away the food or drink which you have taken inside your mouth unmindfully. Since it is burning of a portion of your body, it is important to go ahead with some simple and common first aid before going for a deeper treatment.

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Acupuncture is a form of alternative medicine in which thin needles are inserted into the body. It is a key component of traditional Chinese medicine. TCM theory and practice are not based upon scientific knowledge, and acupuncture is a pseudoscience. There is a diverse range of acupuncture theories based on different philosophies, and techniques vary depending on the country. The method used in TCM is likely the most widespread in the United States. It is most often used for pain relief, though it is also used for a wide range of other conditions. Acupuncture is generally used only in combination with other forms of treatment.

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Ayurveda is a system of medicine with historical roots in the Indian subcontinent. Globalized and modernized practices derived from Ayurveda traditions are a type of complementary or alternative medicine. In countries beyond India, Ayurveda therapies and practices have been integrated in general wellness applications and in some cases in medical use.

The main classical Ayurveda texts begin with accounts of the transmission of medical knowledge from the Gods to sages, and then to human physicians. In Sushruta Samhita (Sushruta's Compendium), Sushruta wrote that Dhanvantari, Hindu god of Ayurveda, incarnated himself as a king of Varanasi and taught medicine to a group of physicians, including Sushruta. Ayurveda therapies have varied and evolved over more than two millennia. Therapies are typically based on complex herbal compounds, minerals and metal substances (perhaps under the influence of early Indian alchemy or rasa shastra). Ancient Ayurveda texts also taught surgical techniques, including rhinoplasty, kidney stone extractions, sutures, and the extraction of foreign objects.

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Does the word "diet" immediately make you think of an unpleasant weight-loss regimen?If it did, you are probably not alone. For example, consider the use of the term "diet" in marketing food products—it usually describes foods low in calories, such as diet soda.But there is another meaning of this word. Diet can also refer to the food and drink a person consumes daily and the mental and physical circumstances connected to eating. Nutrition involves more than simply eating a “good” diet—it is about nourishment on every level. It involves relationships with family, friends, nature (the environment), our bodies, our community, and the world.



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Naturopathic medicine is a distinct primary health care profession, emphasizing prevention, treatment, and optimal

health through the use of therapeutic methods and substances that encourage individuals’ inherent self-healing

process.  The practice of naturopathic medicine includes modern and traditional, scientific, and empirical methods.

 

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Health is the level of functional and metabolic efficiency of a living organism. In humans it is the ability of individuals or communities to adapt and self-manage when facing physical, mental, psychological and social changes with environment. The World Health Organization (WHO) defined health in its broader sense in its 1948 constitution as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity." This definition has been subject to controversy, in particular as lacking operational value, the ambiguity in developing cohesive health strategies, and because of the problem created by use of the word "complete". Other definitions have been proposed, among which a recent definition that correlates health and personal satisfaction. Classification systems such as the WHO Family of International Classifications, including the International Classification of Functioning, Disability and Health (ICF) and the International Classification of Diseases (ICD), are commonly used to define and measure the components of health.
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An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases. Nearly any body part can be involved. Common symptoms include low grade fever and feeling tired. Often symptoms come and go.

The cause is generally unknown. Some autoimmune diseases such as lupus run in families, and certain cases may be triggered by infections or other environmental factors. Some common diseases that are generally considered autoimmune include celiac disease, diabetes mellitus type 1, Graves' disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus. The diagnosis can be difficult to determine.

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The Food and Nutrition Service administers several programs that provide healthy food to children including the National School Lunch Program, School Breakfast Program, Child and Adult Care Food Program, Summer Food Service Program, Fresh Fruit and Vegetable Program, and Special Milk Program.

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Gastroesophageal reflux disease, commonly referred to as GERD or acid reflux, is a condition in which the liquid content of the stomach regurgitates (backs up or refluxes) into the esophagus. The liquid can inflame and damage the lining (esophagitis) although visible signs of inflammation occur in a minority of patients. The regurgitated liquid usually contains acid and pepsin that are produced by the stomach. (Pepsin is an enzyme that begins the digestion of proteins in the stomach.) The refluxed liquid also may contain bile that has backed-up into the stomach from the duodenum. The first part of the small intestine attached to the stomach. Acid is believed to be the most injurious component of the refluxed liquid. Pepsin and bile also may injure the esophagus, but their role in the production of esophageal inflammation and damage is not as clear as the role of acid.


GERD is a chronic condition. Once it begins, it usually is life-long. If there is injury to the lining of the esophagus (esophagitis), this also is a chronic condition. Moreover, after the esophagus has healed with treatment and treatment is stopped, the injury will return in most patients within a few months. Once treatment for GERD is begun it will need to be continued indefinitely although. However, some patients with intermittent symptoms and no esophagitis can be treated only during symptomatic periods.

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Gestational diabetes -- diabetes that develops during pregnancy -- is a relatively common complication of pregnancy, affecting about 6% of all pregnant women.

You may have a greater risk of developing gestational diabetes if you:

Are obese when you become pregnant
Have high blood pressure or other medical complications
Have given birth to a large (greater than 9 pounds) baby before
Have given birth to a baby that was stillborn or suffering from certain birth defects
Have had gestational diabetes in previous pregnancies
Have a family history of diabetes
Come from certain ethnic backgrounds, including African, Hispanic, Asian, Native American, or Pacific Islander
Are older than 30

 

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Gluten is a protein found primarily in wheat, barley and rye. If a person has a gluten intolerance, this protein can cause digestive problems such as gassiness, abdominal pain or diarrhea. Gluten intolerance is sometimes confused with Celiac disease, or thought of as a food allergy.

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Malnutrition refers to deficiencies, excesses or imbalances in a person’s intake of energy and/or nutrients. The term malnutrition covers 2 broad groups of conditions. One is ‘undernutrition’—which includes stunting (low height for age), wasting (low weight for height), underweight (low weight for age) and micronutrient deficiencies or insufficiencies (a lack of important vitamins and minerals). The other is overweight, obesity and diet-related noncommunicable diseases (such as heart disease, stroke, diabetes and cancer)

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Nutrition and pregnancy refers to the nutrient intake, and dietary planning that is undertaken before, during and after pregnancy. Nutrition of the fetus begins at conception. For this reason, the nutrition of the mother is important from before conception (probably several months before) as well as throughout pregnancy and breast feeding. An ever-increasing number of studies have shown that the nutrition of the mother will have an effect on the child, up to and including the risk for cancer, cardiovascular disease, hypertension and diabetes throughout life.

An inadequate or excessive amount of some nutrients may cause malformations or medical problems in the fetus, and neurological disorders and handicaps are a risk that is run by mothers who are malnourished. 23.8% of babies worldwide are estimated to be born with lower than optimal weights at birth due to lack of proper nutrition. Personal habits such as smoking, alcohol, caffeine, using certain medications and street drugs can negatively and irreversibly affect the development of the baby, which happens in the early stages of pregnancy.

Caffeine is sometimes assumed to cause harm to the unborn baby but there is not enough evidence so say if this is true. A recent review showed that more research is needed to show whether caffeine intake effects birth weight, preterm births, gestational diabetes and other outcomes.
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Healthy eating plays a very important role in a healthy pregnancy. You need to eat foods from a variety of sources to make sure you get all the vitamins, minerals and nutrients you and your developing baby need. Eating well will also help you feel better, give you more energy and help you gain a healthy amount of weight. It will also contribute to your baby's healthy growth and development.


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Have you ever felt your fingers and toes going numb? Most of us face this problem once in a while, but if this numbness becomes an everyday thing for you, you need help. Blood serves several important functions in the body. It provides oxygen and nutrients to every cell and organ in the body. It balances body temperature, providing warmth to the fingers, nose and toes.

Poor blood circulation is much more unpleasant than it sounds. It occurs when the blood flow becomes restricted to certain parts of the body like heart, legs, hands, toes, feet and fingers. In mild situations, poor blood circulation causes only discomfort. But if not handled in time, it can lead to several other serious health conditions. The health problems caused due to poor blood circulation include varicose veins, kidney issue and other blood restriction difficulties.

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A relatively new term, “adrenal fatigue” was proposed as a new condition in 1998 by Dr. James L. Wilson, a naturopath and chiropractor. His assumption was that an overstimulation of the adrenal glands (or “adrenals”) by chronic stress over time could lead to an inconsistent level of cortisol (the stress hormone) in the bloodstream, sometimes far more than normal and at other times, far too low. In addition to this overload or improper cortisol level, people with adrenal fatigue often don’t have enough DHEA, the “parent hormone” responsible for the creation of many necessary hormones in the body.

Unlike other endocrine disorders that are caused by physical damage to parts of the adrenal glands, hypoadrenia is seen by many in the natural health world as a “middle ground” syndrome with simple and easy-to-implement solutions. Currently, no official diagnosis exists for adrenal fatigue and people are either considered to have normal endocrine function or total endocrine failure, like that seen in Cushing’s syndrome or adrenal insufficiency/Addison’s disease. 

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Heart and blood vessel disease — also called heart disease — includes numerous problems, many of which are related to a process called atherosclerosis. Atherosclerosis is a condition that develops when a substance called plaque builds up in the walls of the arteries. This buildup narrows the arteries, making it harder for blood to flow through. If a blood clot forms, it can stop the blood flow. This can cause a heart attack or stroke.

A heart attack occurs when the blood flow to a part of the heart is blocked by a blood clot. If this clot cuts off the blood flow completely, the part of the heart muscle supplied by that artery begins to die. Most people survive their first heart attack and return to their normal lives to enjoy many more years of productive activity. But having a heart attack does mean you have to make some changes. 

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A test called a urinalysis can detect whether there is blood in your urine. A urinalysis checks a sample of your urine for different cells, chemicals, and other substances, including blood. Most causes of blood in your urine are not serious, But sometimes red or white blood cells in your urine can mean that you have a medical condition that needs treatment, such as a kidney diseaseurinary tract infection, or liver disease.

Other names: microscopic urine analysis, microscopic examination of urine, urine test, urine analysis, UA

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The Body's Response to Sports Injury. A bruise or 'contusion' is damage to small blood vessels which causes bleeding within the tissues. A muscle strain is a small tear of muscle fibres and a ligament sprain is a small tear of ligament tissue.The Body's Response to Sports Injury. A bruise or 'contusion' is damage to small blood vessels which causes bleeding within the tissues. A muscle strain is a small tear of muscle fibres and a ligament sprain is a small tear of ligament tissue.

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Hyperthyroidism occurs when your thyroid produces too much of the hormone thyroxine. ... An excess of this hormone can cause your body's metabolism to increase, which leads to a rising body temperature. Graves' disease is the most common cause of hyperthyroidism

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Flu is a common infectious viral illness spread by coughs and sneezes. It can be very unpleasant, but you'll usually begin to feel better within about a week.

You can catch flu – short for influenza – all year round, but it's especially common in winter, which is why it's also known as "seasonal flu".

It's not the same as the common cold. Flu is caused by a different group of viruses and the symptoms tend to start more suddenly, be more severe and last longer.

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UTIs are a key reason we're often told to wipe from front to back after using the bathroom. That's because the urethra -- the tube that transports urine from the bladder to the outside of the body -- is located close to the anus. Bacteria from the large intestine, such as E. coli, are in the perfect position to escape the anus and invade the urethra. From there, they can travel up to the bladder, and if the infection isn't treated, continue on to infect the kidneys. Women may be especially prone to UTIs because they have shorter urethras, which allow bacteria quick access to the bladder. Having sex can introduce bacteria into the urinary tract, too.

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Cellulite is a term for lumpy, dimpled flesh on the thighs, hips, buttocks and abdomen. It's most common in adolescent and adult women. Although not a serious medical condition, your cellulite might embarrass you.

Many cellulite treatments, including massages or cellulite creams, advertise remarkable results. Most of these treatments don't live up to their claims. Researchers are studying possible medical treatments. In the meantime, you can take steps to slightly improve the appearance of cellulite.

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An albumin blood test measures the amount of albumin in your blood. Albumin is a protein made by your liver. Albumin helps keep fluid in your bloodstream so it doesn't leak into other tissues. It is also carries various substances throughout your body, including hormones, vitamins, and enzymes. Low albumin levels can indicate a problem with your liver or kidneys.

Other names: ALB

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Bacteria are a large group of one-celled organisms. They can live on different places in the body. Some types of bacteria are harmless or even beneficial. Others can cause infections and disease. A bacteria culture test can help find harmful bacteria in your body. During a bacteria culture test, a sample will be taken from your blood, urine, skin, or other part of your body. The type of sample depends on the location of the suspected infection. The cells in your sample will be taken to a lab and put in a special environment in a lab to encourage cell growth. Results are often available within a few days. But some types of bacteria grow slowly, and it may take several days or longer.

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A bilirubin blood test measures the levels of bilirubin in your blood. Bilirubin is a yellowish substance made during the body's normal process of breaking down red blood cells. Bilirubin is found in bile, a fluid in your liver that helps you digest food. If your liver is healthy, it will remove most of the bilirubin from your body. If your liver is damaged, bilirubin can leak out of your liver and into your blood. When too much bilirubin gets into the bloodstream, it can cause jaundice, a condition that causes your skin and eyes to turn yellow. Signs of jaundice, along with a bilirubin blood test, can help your health care provider find out if you have liver disease.

Other names: Total serum bilirubin, TSB

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Bilirubin in urine is a diagnostic marker used to detect the presence of bilirubin in urine. Typically, bilirubin is not present in urine at detectable levels, as it is largely processed by the liver and eliminated from the body in the feces. However, if the liver is not functioning properly, or if there is a blockage in the bile ducts, bilirubin may accumulate in the bloodstream and be excreted in the urine.

The presence of bilirubin in urine can be a sign of liver or gallbladder disease, certain types of anemia, or other health conditions. A bilirubin in urine test is a non-invasive diagnostic procedure that can help identify these conditions and guide appropriate treatment. The test is typically performed by collecting a urine sample and analyzing it in a laboratory.


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A blood glucose test measures the glucose levels in your blood. Glucose is a type of sugar. It is your body's main source of energy. A hormone called insulin helps move glucose from your bloodstream into your cells. Too much or too little glucose in the blood can be a sign of a serious medical condition. High blood glucose levels (hyperglycemia) may be a sign of diabetes, a disorder that can cause heart diseaseblindnesskidney failure and other complications. Low blood glucose levels (hypoglycemia) can also lead to major health problems, including brain damage, if not treated.

Other names: blood sugar, self-monitoring of blood glucose (SMBG), fasting plasma glucose (FPG), fasting blood sugar (FBS), fasting blood glucose (FBG), glucose challenge test, oral glucose tolerance test (OGTT)

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A BUN, or blood urea nitrogen test, can provide important information about your kidney function. The main job of your kidneys is to remove waste and extra fluid from your body. If you have kidney disease, this waste material can build up in your blood and may lead to serious health problems, including high blood pressureanemia, and heart disease.

The test measures the amount of urea nitrogen in your blood. Urea nitrogen is one of the waste products removed from your blood by your kidneys. Higher than normal BUN levels may be a sign that your kidneys aren't working efficiently.

People with early kidney disease may not have any symptoms. A BUN test can help uncover kidney problems at an early stage when treatment can be more effective.

Other names for a BUN test: Urea nitrogen test, serum BUN

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The kidneys are two bean-shaped organs located on each side of the spine. They’re responsible for filtering out of the blood waste products, excess water, and other impurities. These important organs also control the pH, salt levels, and potassium levels in the body. The kidneys even produce hormones that manage red blood cell production and regulate blood pressure.

A blood urea nitrogen (BUN) test is used to determine how well your kidneys are working. It does this by measuring the amount of urea nitrogen in the blood. Urea nitrogen is a waste product that’s created in the liver when the body breaks down proteins. Normally, the kidneys filter out this waste, and urinating removes it from the body.

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A calcium blood test measures the amount of calcium in your blood. Calcium is one of the most important minerals in your body. You need calcium for healthy bones and teeth. Calcium is also essential for proper functioning of your nerves, muscles, and heart. About 99% of your body's calcium is stored in your bones. The remaining 1% circulates in the blood. If there is too much or too little calcium in the blood, it may be a sign of bone diseasethyroid diseasekidney disease, or other medical conditions.

Other names: total calcium, ionized calcium

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A calcium in urine test measures the amount of calcium in your urine. Calcium is one of the most important minerals in your body. You need calcium for healthy bones and teeth. Calcium is also essential for proper functioning of your nerves, muscles, and heart. Almost all of your body's calcium is stored in your bones. A small amount circulates in the blood, and the remainder is filtered by the kidneys and passed into your urine. If urine calcium levels are too high or too low, it may mean you have a medical condition, such as kidney disease or kidney stones. Kidney stones are hard, pebble-like substances that can form in one or both kidneys when calcium or other minerals build up in the urine. Most kidney stones are formed from calcium.

Too much or too little calcium in the blood can also indicate a kidney disorder, as well as certain bone diseases, and other medical problems. So if you have symptoms of one of these disorders, your health care provider may order a calcium blood test, along with a calcium in urine test. In addition, a calcium blood test is often included as part of a regular check-up.

Other names: urinalysis (calcium)

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A complete blood count or CBC is a blood test that measures many different parts and features of your blood, including:

  • Red blood cells, which carry oxygen from your lungs to the rest of your body
  • White blood cells, which fight infection. There are five major types of white blood cells. A CBC test measures the total number of white cells in your blood. A test called a CBC with differentialalso measures the number of each type of these white blood cells
  • Platelets, which help your blood to clot and stop bleeding
  • Hemoglobin, a protein in red blood cells that carries oxygen from your lungs and to the rest of your body
  • Hematocrit, a measurement of how much of your blood is made up of red blood

A complete blood count may also include measurements of chemicals and other substances in your blood. These results can give your health care provider important information about your overall health and risk for certain diseases.

Other names for a complete blood count: CBC, full blood count, blood cell count

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A bone spur (osteophyte) is a bony growth formed on normal bone. Most people think of something sharp when they think of a "spur," but a bone spur is just extra bone. It's usually smooth, but it can cause wear and tear or pain if it presses or rubs on other bones or soft tissues such as ligaments, tendons, or nerves in the body. Common places for bone spurs include the spine, shoulders, hands, hips, knees, and feet.

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Your urine contains many chemicals. Sometimes these chemicals form solids, called crystals. A crystals in urine test looks at the amount, size, and type of crystals in your urine. It's normal to have a few small urine crystals. Larger crystals or specific types of crystals can become kidney stones. Kidney stones are hard, pebble-like substances that can get stuck in the kidneys. A stone can be as small as a grain of sand, as big as a pea, or even larger. While kidney stones rarely cause serious damage, they can be very painful.

Other names: urinalysis (crystals) microscopic urine analysis, microscopic examination of urine

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A drug test looks for the presence of one or more illegal or prescription drugs in your urine, blood, saliva, hair, or sweat. Urine testing is the most common type of drug screening. The drugs most often tested for include:

  • Marijuana
  • Opioids, such as heroin, codeine, oxycodone, morphine, hydrocodone, and fentanyl
  • Amphetamines, including methamphetamine
  • Cocaine
  • Steroids
  • Barbiturates, such as phenobarbital and secobarbital
  • Phencyclidine (PCP)

Other names: drug screen, drug test, drugs of abuse testing, substance abuse testing, toxicology screen, tox screen, sports doping tests.

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Have you heard about Epithelial cells? Well, they are the most essential part of the body's protective system to protect against infections and inflammation. These cells are present in the urine in a normal percentage. However, if there's a sudden increased amount of Epithelial Cells in Urine beyond the normal range then it can lead to health issues. That's why it's important to know about Epithelial cells. In this article, we've covered Epithelial cells, their types, risk factors, and how these levels are tested. 


So, without any further delay, let's dive in.

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A fecal occult blood test (FOBT) looks at a sample of your stool (feces) to check for blood. Occult blood means that you can't see it with the naked eye. Blood in the stool means there is likely some kind of bleeding in the digestive tract. It may be caused by a variety of conditions, including:

  • Polyps
  • Hemorrhoids
  • Diverticulosis
  • Ulcers
  • Colitis, a type of inflammatory bowel disease

Blood in the stool may also be a sign of colorectal cancer, a type of cancer that starts in the colon or rectum. Colorectal cancer is the second leading cause of cancer-related deaths in the United States and the third most common cancer in men and in women. A fecal occult blood test is a screening test that may help find colorectal cancer early, when treatment is most effective.

Other names: FOBT, stool occult blood, occult blood test, Hemoccult test, guaiac smear test, gFOBT, immunochemical FOBT, iFOBT; FIT

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Globulins are a group of proteins in your blood. They are made in your liver by your immune system. Globulins play an important role in liver function, blood clotting, and fighting infection. There are four main types of globulins. They are called alpha 1, alpha 2, beta, and gamma. Just as there are different types of globulins, there are different types of globulin tests. These include:

  • Total protein test. This blood test measures two types of proteins: globulin and albumin. If protein levels are low, it can mean that you have liver or kidney disease.
  • Serum protein electrophoresis. This blood test measures gamma globulins and other proteins in your blood. It can be used to diagnose a variety of conditions, including disorders of the immune system and a type of cancer called multiple myeloma.

Other names for globulin tests: Serum globulin electrophoresis, total protein

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glucose in urine test measures the amount of glucose in your urine. Glucose is a type of sugar. It is your body's main source of energy. A hormone called insulin helps move glucose from your bloodstream into your cells. If too much glucose gets into the blood, the extra glucose will be eliminated through your urine. A urine glucose test can be used to help determine if blood glucose levels are too high, which may be a sign of diabetes.

Other names: urine sugar test; urine glucose test; glucosuria test

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The test measures ketone levels in your urine. Normally, your body burns glucose (sugar) for energy. If your cells don't get enough glucose, your body burns fat for energy instead. This produces a substance called ketones, which can show up in your blood and urine. High ketone levels in urine may indicate diabetic ketoacidosis (DKA), a complication of diabetes that can lead to a coma or even death. A ketones in urine test can prompt you to get treatment before a medical emergency occurs.

Other names: ketones urine test, ketone test, urine ketones, ketone bodies

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MCV stands for mean corpuscular volume. There are three main types of corpuscles (blood cells) in your blood–red blood cells, white blood cells, and platelets. An MCV blood test measures the average size of your red blood cells, also known as erythrocytes. Red blood cells move oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. If your red blood cells are too small or too large, it could be a sign of a blood disorder such as anemia, a vitamin deficiency, or other medical condition.

Other names: CBC with differential

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Mucus is a thick, slimy substance that coats and moistens certain parts of the body, including the nose, mouth, throat, and urinary tract. A small amount of mucus in your urine is normal. An excess amount may indicate a urinary tract infection (UTI) or other medical condition. A test called urinalysis can detect whether there is too much mucus in your urine.

Other names: microscopic urine analysis, microscopic examination of urine, urine test, urine analysis, UA

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urinalysis, also called a urine test, can detect the presence of nitrites in the urine. Normal urine contains chemicals called nitrates. If bacteria enter the urinary tract, nitrates can turn into different, similarly named chemicals called nitrites. Nitrites in urine may be a sign of a urinary tract infection(UTI).

UTIs are one of the most common types of infections, especially in women. Fortunately, most UTIs are not serious and are usually treated with antibiotics. It's important to see your health care provider if you have symptoms of a UTI so you can start treatment right away.

Other names: urine test, urine analysis, microscopic urine analysis, microscopic examination of urine, UA

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potassium blood test measures the amount of potassium in your blood. Potassium is a type of electrolyte. Electrolytes are electrically charged minerals in your body that help control muscle and nerve activity, maintain fluid levels, and perform other important functions. Your body needs potassium to help your heart and muscles work properly. Potassium levels that are too high or too low may indicate a medical problem.

Other names: potassium serum, serum potassium, serum electrolytes, k


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A protein in urine test measures how much protein is in your urine. Proteins are substances that are essential for your body to function properly. Protein is normally found in the blood. If there is a problem with your kidneys, protein can leak into your urine. While a small amount is normal, a large amount of protein in urine may indicate kidney disease.

Other names: urine protein, 24-hour urine protein; urine total protein; ratio; reagent strip urinalysis.

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A red cell distribution width (RDW) test is a measurement of the range in the volume and size of your red blood cells (erythrocytes). Red blood cells move oxygen from your lungs to every cell in your body. Your cells need oxygen to grow, reproduce, and stay healthy. If your red blood cells are larger than normal, it could indicate a medical problem.

Other names: RDW-SD (standard deviation) test, Erythrocyte Distribution Width

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A sodium blood test measures the amount of sodium in your blood. Sodium is a type of electrolyte. Electrolytes are electrically charged minerals that help maintain fluid levels and the balance of chemicals in your body called acids and bases. Sodium also helps your nerves and muscles work properly.

You get most of the sodium you need in your diet. Once your body takes in enough sodium, the kidneys get rid of the rest in your urine. If your sodium blood levels are too high or too low, it may mean that you have a problem with your kidneys, dehydration, or another medical condition.

Other names: Na test

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TSH stands for thyroid stimulating hormone. A TSH test is a blood test that measures this hormone. The thyroid is a small, butterfly-shaped gland located near your throat. Your thyroid makes hormones that regulate the way your body uses energy. It also plays an important role in regulating your weight, body temperature, muscle strength, and even your mood. TSH is made in a gland in the brain called the pituitary. When thyroid levels in your body are low, the pituitary gland makes more TSH. When thyroid levels are high, the pituitary gland makes less TSH. TSH levels that are too high or too low can indicate your thyroid isn't working correctly.

Other names: thyrotropin test.

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A urobilinogen in urine test measures the amount of urobilinogen in a urine sample. Urobilinogen is formed from the reduction of bilirubin. Bilirubin is a yellowish substance found in your liver that helps break down red blood cells. Normal urine contains some urobilinogen. If there is little or no urobilinogen in urine, it can mean your liver isn't working correctly. Too much urobilinogen in urine can indicate a liver disease such as hepatitis or cirrhosis.

Other names: urine test; urine analysis; UA, chemical urinalysis

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When we breathe, we do not often think of the complex process that is necessary to keep oxygen flowing through the body. The lungs are crucial to this, as they pass oxygen into the bloodstream and remove carbon dioxide that is then expelled from the body.

While a person can live a normal life with only 30 percent of lung function, there are thousands of people whose lungs have been damaged more significantly, and therefore, need a transplant to survive. Although some of the conditions that result in requiring a lung transplant are hereditary, most are caused or worsened by smoking or environmental pollution.


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Rehabilitation of sensory and cognitive function typically involves methods for retraining neural pathways or training new neural pathways to regain or improve neurocognitive functioning that has been diminished by disease or trauma. Three common neuropsychological problems treatable with rehabilitation are attention deficit/hyperactivity disorder (ADHD), concussion, and spinal cord injury. Rehabilitation research and practices are a fertile area for clinical neuropsychologists and others.


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Drug rehabilitation (often drug rehab or just rehab) is the processes of medical or psychotherapeutic  treatment for dependency on psychoactive substances such as alcohol, prescription drugs, and street drugs such as cocaine, heroin or amphetamines. The general intent is to enable the patient to confront substance dependence, if present, and cease substance abuse to avoid the psychological, legal, financial, social, and physical consequences that can be caused, especially by extreme abuse. Treatment includes medication for depression or other disorders, counseling by experts and sharing of experience with other addicts.


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Occupational rehabilitation is the process of restoring function to injured workers so they can return to work. Rehabilitation professionals assess the needs of the person and the demands of the workplace in order to develop a plan of action to get the employee back to work that is suitable and safe for him as soon as possible. Depending on the type of injury, the individual may have to be trained in a new line of work.

A number of professionals are involved in the practice of occupational rehabilitation. Doctors, physiotherapists, occupational therapists, psychologists and massage therapists all have a different role in the rehabilitation of injured workers. Some of the problems treated by these clinicians are amputations, overuse injuries, back pain, neck pain, headaches, fractures, spinal cord injuries, and a host of other injuries.

Increased computer usage has resulted in a growing number of people seeking occupational rehabilitation because of common overuse conditions such as carpal tunnel syndrome, tendonitis, as well as problems brought on by poor sustained postures such as thoracic outlet syndrome or cervical headaches. Other common work injuries are lower back problems such as intervertebral disc bulges especially among those who work with heavy machinery. Physiotherapists and occupational therapists work together to improve the employee's posture (standing as well as sitting), the ergonomics of the work place and the way the individual performs his duties. Many problems like shoulder, back and neck pain, which were believed to be chronic, have been improved by making adjustments in workplace ergonomics and posture and through exercise programmes to restore correct muscle balance and joint alignment.

Active rehabilitation programmes in gym-based settings are a proactive way to rehabilitate injured workers. Once the initial injury has been treated by the physiotherapist in the clinic, many physiotherapists are now designing and supervising exercise programmes in local gymnasiums. These exercise programmes aim to accelerate the return of strength and function of the injured workers and prevent re-injury on their return to work, often with excellent results. Many patients finish the rehabilitation programmes stronger and fitter than before they were even injured and with a renewed passion for exercise!

By participating in active rehabilitation, injured workers can prevent loss of wages due to injuries and can enjoy a more productive working environment. Employers can preserve their bottom line by avoiding decreased man-hours and ongoing medical expenses. With a physiotherapy prescribed rehabilitation programme everyone benefits.

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Regular health exams and tests can help find problems before they start. They also can help find problems early, when your chances for treatment and cure are better. Which exams and screenings you need depends on your age, health and family history, and lifestyle choices such as what you eat, how active you are, and whether you smoke.


To make the most of your next check-up, here are some things to do before you go:

Review your family health history

Find out if you are due for any general screenings or vaccinations

Write down a list of issues and questions to take with you


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Breasts develop from embryological tissues, and the high estrogen level in females during puberty causes breasts to start growing bigger.

Breasts are mammary glands composed of layers of different types of tissue, including adipose, glandular and connective tissues. As these tissues have hormone receptors, there is often fluctuation in breast sizes and volumes based on hormonal changes in the body.

As breasts are considered a sign of femininity and beauty, women want their breasts to be perfectly shaped and sized. However, at times the breasts become larger in size, which can be due to several factors including genetics, obesity, pregnancy, breastfeeding, hormonal changes in the body and side effects of certain drugs.

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The brain is the body organ composed of nerve cells and supportive tissues like glial cells and meninges – there are three major parts – they control your activity like breathing (brain stem), activity like moving muscles to walk (cerebellum) and your senses like sight and our memory, emotions, thinking and personality (cerebrum).

Primary brain tumors can be either malignant (contain cancer cells) or benign (do not contain cancer cells). A primary brain tumor is a tumor which begins in the brain tissue. If a cancerous tumor starts elsewhere in the body, it can spread cancer cells, which grow in the brain. These type of tumors are called secondary or metastatic brain tumors.

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A chronic cough is a cough that lasts eight weeks or longer in adults, or four weeks in children.


A chronic cough is more than just an annoyance. A chronic cough can interrupt your sleep and leave you feeling exhausted. Severe cases of chronic cough can cause vomiting, lightheadedness and even rib fractures.


While it can sometimes be difficult to pinpoint the problem that's triggering a chronic cough, the most common causes are tobacco use, postnasal drip, asthma and acid reflux. Fortunately, chronic cough typically disappears once the underlying problem is treated.

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Eustachian tubes are small tubes that run between your middle ears and the upper throat. They are responsible for equalizing ear pressure and draining fluid from the middle ear, the part of the ear behind the eardrum. The eustachian tubes are usually closed except for when you chew, swallow, or yawn.


These passageways are small in size and can get plugged for a variety of reasons. Blocked eustachian tubes can cause pain, hearing difficulties, and a feeling of fullness in the ears. Such a phenomenon is referred to as eustachian tube dysfunction (ETD).


ETD is a relatively common condition. Depending on the cause, it may resolve on its own or through simple at-home treatment measures. Severe or recurring cases may require a visit to the doctor.

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Post-traumatic stress disorder (PTSD) is a mental health condition that's triggered by a terrifying event — either experiencing it or witnessing it. Symptoms may include flashbacks, nightmares and severe anxiety, as well as uncontrollable thoughts about the event.Most people who go through traumatic events may have temporary difficulty adjusting and coping, but with time and good self-care, they usually get better. If the symptoms get worse, last for months or even years, and interfere with your day-to-day functioning, you may have PTSD.Getting effective treatment after PTSD symptoms develop can be critical to reduce symptoms and improve function

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Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes: type 1 diabetes, type 2 diabetes, and gestational diabetes.


All types of diabetes mellitus have something in common. Normally, your body breaks down the sugars and carbohydrates you eat into a special sugar called glucose. Glucose fuels the cells in your body. But the cells need insulin, a hormone, in your bloodstream in order to take in the glucose and use it for energy. With diabetes mellitus, either your body doesn't make enough insulin, it can't use the insulin it does produce, or a combination of both.


Since the cells can't take in the glucose, it builds up in your blood. High levels of blood glucose can damage the tiny blood vessels in your kidneys, heart, eyes, or nervous system. That's why diabetes -- especially if left untreated -- can eventually cause heart disease, stroke, kidney disease, blindness, and nerve damage to nerves in the feet.

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Diabetes insipidus (die-uh-BEE-teze in-SIP-uh-dus) is an uncommon disorder that causes an imbalance of water in the body. This imbalance leads to intense thirst even after drinking fluids (polydipsia), and excretion of large amounts of urine (polyuria).


While the names diabetes insipidus and diabetes mellitus sound similar, they're not related. Diabetes mellitus — which can occur as type 1 or type 2 — is the more common form of diabetes.


There's no cure for diabetes insipidus, but treatments are available to relieve your thirst and normalize your urine output.

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Bruises often induce pain, but small bruises are not normally dangerous alone. Sometimes bruises can be serious, leading to other more life-threatening forms of hematoma, such as when associated with serious injuries, including fractures and more severe internal bleeding. The likelihood and severity of bruising depends on many factors, including type and healthiness of affected tissues. Minor bruises may be easily recognized in people with light skin color by characteristic blue or purple appearance (idiomatically described as "black and blue") in the days following the injury.

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 Burns are a serious public health problem. A burn is defined as an injury to the skin or other organic tissue primarily caused by heat or due to radiation, radioactivity, electricity, friction or contact with chemicals.

Heat burns occur when some or all of the different layers of cells in the skin are destroyed by a hot liquid (scald), a hot solid (contact burn) or a flame (flame burn). Skin injuries due to ultraviolet radiation, radioactivity, electricity or chemicals, as well as respiratory damage resulting from smoke inhalation, are also considered as burns.

According to WHO estimates about 265 000 deaths occur each year from fires alone globally, with more deaths from scalds, electrical burns, and other forms of burns for which data are not available. The majority of these deaths occur in low- and middle-income countries, with almost half occur in the WHO South-East Asia Region.

In India around 7 million people suffer from burn injuries each year with 1.4 lakh deaths and 2.4 lakh people suffer with disability. Burn death rates have been decreasing in high income countries.

Females and males show similar rates for burns in contrast to other injury patterns where rates of injury are higher in males than females. The higher risk for females is associated with open fire cooking, or unsafe cook stoves, loose clothing. Self-directed or interpersonal violence is also a factor for burn injuries.

Along with adult females, children are also vulnerable to burns. Out of 5 burn victims 4 are women and children. Burns are the fifth most common cause of non-fatal childhood injuries and 11th leading cause of death of children aged 1-9 years. Among all people globally, infants have the highest death rates from burns.

Burns are also a leading cause of morbidity; millions who survive suffer from lifelong disability and disfigurements with resulting emotional trauma and stigma.

Burns are preventable. Increased efforts in prevention and care would lead to significant reduction in burn-related morbidity, mortality and disability.

The National Programme for Prevention, Management and Rehabilitation of Burn Injuries (NPPMRBI) is an initiative by the Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India to strengthen the preventive, curative and rehabilitative services for burn victims.

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Acupressure [from Latin acus "needle" (see acuity) + pressure (n.)] is an alternative medicine technique similar in principle to acupuncture. It is based on the concept of life energy which flows through "meridians" in the body. In treatment, physical pressure is applied to acupuncture points with the aim of clearing blockages in these meridians. Pressure may be applied by hand, by elbow, or with various devices.

Some medical studies have suggested that acupressure may be effective at helping manage nausea and vomiting, for helping lower back pain, tension headaches, stomach ache, among other things, although such studies have been found to have a high likelihood of bias. Like many alternative medicines, it may benefit from a placebo effect.

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A burning sensation in your feet may be caused by nerve damage in the legs, also called neuropathy. Although many medical conditions can cause burning feet, diabetes is the most common. Most burning feet treatments focus on preventing further nerve damage and reducing pain.

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The "murmur" is the sound of blood flowing. It may be passing through a problem heart valve, for instance. Or it may be that a condition makes your heart beat faster and forces your heart to handle more blood quicker than normal.

Most are innocent and don't require any treatment.

But there are exceptions. Murmurs can be linked to a damaged or overworked heart valve. Some people are born with valve problems. Others get them as a part of aging or from other heart problems.

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Cryoglobulinemia is a medical condition that is caused by proteins called cryoglobulins, which are present in the blood. Cryoglobulins are abnormal proteins that by definition have the unusual property of precipitating from the serum when it is chilled in the laboratory and then dissolves back into the serum upon rewarming.


Cryoglobulins may or may not cause disease. Cryoglobulins can accompany another condition (such as dermatomyositis, multiple myeloma, viral infections, or lymphoma) or be an isolated condition themselves, called cryoglobulinemia.

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A burn is a type of injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or radiation. Most burns are due to heat from hot liquids, solids, or fire. While rates are similar for males and females the underlying causes often differ. Among women in some areas, risk is related to use of open cooking fires or unsafe cook stoves. Amongong men, risk is related to the work environments. Alcoholism and smoking are other risk factors. Burns can also occur as a result of self harm or violence between people.

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Newborn jaundice is a yellowing of a baby’s skin and eyes. Newborn jaundice is very common and can occur when babies have a high level of bilirubin, a yellow pigment produced during normal breakdown of red blood cells. In older babies and adults, the liver processes bilirubin, which then passes it through the intestinal tract. However, a newborn’s still-developing liver may not be mature enough to remove bilirubin.


The good news is that in most cases, newborn jaundice goes away on its own as a baby’s liver develops and as the baby begins to feed, which helps bilirubin pass through the body.


In most cases, jaundice will disappear within 2 to 3 weeks. Jaundice that persists longer than three weeks may be a symptom of an underlying condition. Additionally, high levels of bilirubin can put a baby at risk for deafness, cerebral palsy, or other forms of brain damage. That’s why the American Academy of Pediatrics (AAP) recommends that all newborn babies be examined for jaundice every time their vital signs are measured (or at least every 8 to 12 hours), before discharge from the hospital, and again a few days after discharge.

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Lichen planus is a chronic recurrent inflammatory disorder of the skin and mucous membranes. It is characterized by small, flat-topped, polygonal bumps that may coalesce into rough, scaly plaques on the skin. There may also be involvement of the lining tissue (mucous membranes) of the mouth and/or vagina.


Lichen planus is a poorly understood skin condition. Its name is descriptive in that to some it resembles a simple plant, a lichen, which grows on rocks and tree bark, while planus is Latin for flat.

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Botulism (or botulism poisoning) is a rare but very serious illness that transmits through food, contact with contaminated soil, or through an open wound. Without early treatment, botulism can lead to paralysis, breathing difficulties, and death.

There are three main types of botulism:

    infant botulism
    foodborne botulism
    wound botulism

Botulism poisoning is due to a toxin produced by a type of bacteria called Clostridium botulinum. Although very common, these bacteria can only thrive in conditions where there’s no oxygen. Certain food sources, such as home-canned foods, provide a potent breeding ground.

According to the Centers for Disease Control and Prevention (CDC), about 145 cases of botulism are reported every year in the United States. About 3 to 5 percent of those with botulism poisoning die.

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Dengue fever is a disease caused by a family of viruses transmitted by mosquitoes. It is an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pain, swollen lymph nodes (lymphadenopathy), and rash. The presence of fever, itchy rash, and headache (the "dengue triad") is characteristic of dengue. Other signs of dengue fever include bleeding gums, severe pain behind the eyes, and red palms and soles.

Dengue (pronounced DENG-gay) can affect anyone but tends to be more severe in people with compromised immune systems. Because it is caused by one of five serotypes of the dengue virus, it is possible to get dengue fever multiple times. However, an attack of dengue produces immunity for a lifetime to that particular viral serotype to which the patient was exposed.

Dengue goes by other names, including "breakbone fever" or "dandy fever." Victims of dengue often have contortions due to the intense pain in the joints, muscles, and bones, hence the name breakbone fever. Slaves in the West Indies who contracted dengue were said to have dandy fever because of their postures and gait.

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Calluses are hard and rough-feeling areas of skin that can develop on hands, feet or anywhere there is repeated friction - even on a violinist's chin. Like corns, calluses have several variants. The common callus usually occurs when there has been a lot of rubbing against the hands or feet. A plantar callus is found on the bottom of the foot.Calluses are hard and rough-feeling areas of skin that can develop on hands, feet or anywhere there is repeated friction - even on a violinist's chin. Like corns, calluses have several variants. The common callus usually occurs when there has been a lot of rubbing against the hands or feet. A plantar callus is found on the bottom of the foot.

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Thrush (oropharyngeal candidiasis) is a medical condition in which a yeast-shaped fungus called Candida overgrows in the mouth and throat. Candida is normally present in the mouth, digestive tract, and skin of most healthy people. The immune system and the body's normal bacteria usually keep Candida in balance. When this balance is interrupted, it can result in an overgrowth of the Candida fungus, causing thrush, a yeast infection of the mouth or throat.

Thrush is not the same as a vaginal yeast infection. However, the Candida fungus also causes diaper rash, but diaper rash occurs on a child's rear end, genitals, and inner thighs, while oral thrush occurs in the mouth and throat. Adults may get yeast infections in areas of overlapping skin, such as underneath breasts or in skin folds like creases in skin due to fatty tissue.

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West Nile fever is a viral infection typically spread by mosquitoes. In about 75% of infections people have few or no symptoms. About 20% of people develop a fever, headache, vomiting, or a rash

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Chronic Obstructive Pulmonary Disease (COPD) is an umbrella term used to describe progressive lung diseases including emphysema, chronic bronchitis, refractory (non-reversible) asthma, and some forms of bronchiectasis. This disease is characterized by increasing breathlessness.

Many people mistake their increased breathlessness and coughing as a normal part of aging. In the early stages of the disease, you may not notice the symptoms. COPD can develop for years without noticeable shortness of breath. You begin to see the symptoms in the more developed stages of the disease. That’s why it is important that you talk to your doctor as soon as you notice any of these symptoms. Ask your doctor about taking a spirometry test.


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Severe acute respiratory syndrome (SARS) is a serious form of pneumonia. It is caused by a virus that was first identified in 2003. Infection with the SARS virus causes acute respiratory distress (severe breathing difficulty) and sometimes death.


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You probably know that smoking tobacco isn’t great for your health. A recent report by the U.S. surgeon general attributes nearly half a million deaths annually to smoking. Your lungs are one of the organs that’s most impacted by tobacco. Here’s how smoking affects your lungs and your overall health.


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There are six basic types of nutrients that are considered essential to life: proteins, carbohydrates, fats, vitamins, minerals, and water. These nutrients are needed for your body to function properly, and your diet is the source of them. Vitamins and minerals are considered micronutrients because they are needed in smaller quantities than the macronutrients (protein, carbohydrates, and fat). Micronutrients do not provide calories. When your body does not absorb an adequate amount of any of the micronutrients, diseases can occur. It's important to understand what your nutritional needs are and how to achieve them.Vitamins are broken down into two categories: water-soluble and fat-soluble. Water-soluble vitamins dissolve in water. Leftover amounts are not stored and will leave your body through your urine. For this reason, you must consume them on a continuous basis. The water-soluble vitamins are the B vitamins and vitamin C. Fat-soluble vitamins dissolve in fat, not water. These vitamins need dietary fat in order to be better absorbed in the small intestines. They are then stored in the liver and fatty tissues (adipose tissues) and can accumulate to toxic levels when consumed in excess quantities. The fat-soluble vitamins are vitamins A, D, E, and K.Recommendations for essential nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Institute of Medicine of the National Academies. Dietary Reference Intakes is the general term for a set of reference values used for planning and assessing nutrient intake for healthy people. There are three important types of DRI reference values; Recommended Dietary Allowances (RDA), Adequate Intakes (AI), and Tolerable Upper Intake Levels (UL). The RDA is set to meet the nutrient requirements for the average daily intake of nearly all healthy individuals in each age and gender group. When there is insufficient data to set an RDA for a nutrient, an AI is set. AIs meet or exceed the amount needed to maintain an adequate nutritional state in nearly everyone of a specific age and gender group. Some nutrients can cause health problems when consumed in excessive quantities. The UL was set to provide the maximum daily intake that is unlikely to result in adverse health effects. Numerous health conditions, however, can impact your nutritional needs. A registered dietitian or physician can help you better determine your needs based upon your overall health and condition.


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Some sexually transmitted infections can spread through the use of unsterilized drug needles, from mother to baby during childbirth, or breast-feeding, and blood transfusions.

Sexually transmitted infections have been around for thousands of years. The genital areas are generally moist and warm environments - ideal for the growth of yeasts, viruses, and bacteria.

Microorganisms that exists on the skin or mucus membranes of the male or female genital area can be transmitted, as can organisms in semen, vaginal secretions, or blood during sexual intercourse.


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Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis. Whether they are caused by a health problem or by too much stress, sleep disorders are becoming increasingly common in the United States. In fact, more than 75 percent of Americans between ages 20 and 59 report having sleeping difficulties fairly regularly.

Most people occasionally experience sleeping problems due to stress, hectic schedules, and other outside influences. However, when these issues begin to occur on a regular basis and interfere with daily life, they may indicate a sleeping disorder.

Depending on the type of sleep disorder, people may have a difficult time falling asleep and may feel extremely tired throughout the day. The lack of sleep can have a negative impact on energy, mood, concentration, and overall health.

In some cases, sleep disorders can be a symptom of another medical or mental health condition. These sleeping problems may eventually go away once treatment is obtained for the underlying cause. When sleep disorders aren’t caused by another condition, treatment normally involves a combination of medical treatments and lifestyle changes.

It’s important to receive a diagnosis and treatment right away if you suspect you might have a sleep disorder. When left untreated, the negative effects of sleep disorders can lead to further health consequences. They can also affect your performance at work, cause strain in relationships, and impair your ability to perform daily activities.

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Thyroid nodules are solid or fluid-filled lumps that form within your thyroid, a small gland located at the base of your neck, just above your breastbone.

The great majority of thyroid nodules aren't serious and don't cause symptoms. Thyroid cancer accounts for only a small percentage of thyroid nodules.

You often won't know you have a thyroid nodule until your doctor discovers it during a routine medical exam. Some thyroid nodules, however, may become large enough to be visible or make it difficult to swallow or breathe.

Treatment options depend on the type of thyroid nodule you have.

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Cellulite affects about 80% of all women. A poor diet, lack of physical activity, hormone changes, genetics and overall body fat are the main reasons for the ugly dimples. Women typically store this excess fat in the buttocks and hip area. Fortunately, there are many things you can do to get rid of it.

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Cellulitis (sel-u-LIE-tis) is a common, potentially serious bacterial skin infection. Cellulitis appears as a swollen, red area of skin that feels hot and tender. It can spread rapidly to other parts of the body. Cellulitis isn't usually spread from person to person.

Skin on lower legs is most commonly affected, though cellulitis can occur anywhere on your body or face. Cellulitis might affect only your skin's surface. Or it might also affect tissues underlying your skin and can spread to your lymph nodes and bloodstream.

Left untreated, the spreading infection can rapidly turn life-threatening. It's important to seek immediate medical attention if cellulitis symptoms occur.

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Premenstrual syndrome (PMS) refers to the range of physical and emotional symptoms many women experience in the lead up to a period. Premenstrual dysphoric disorder (PMDD) is a more serious form of PMS. Here you will find information on PMS, PMDD symptoms, causes and treatments.


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Chronic kidney disease includes conditions that damage your kidneys and decrease their ability to keep you healthy by doing the jobs listed. If kidney disease gets worse, wastes can build to high levels in your blood and make you feel sick. You may develop complications like high blood pressure, anemia (low blood count), weak bones, poor nutritional health and nerve damage. Also, kidney disease increases your risk of having heart and blood vessel disease. These problems may happen slowly over a long period of time. Chronic kidney disease may be caused by diabetes, high blood pressure and other disorders. Early detection and treatment can often keep chronic kidney disease from getting worse. When kidney disease progresses, it may eventually lead to kidney failure, which requires dialysis or a kidney transplant to maintain life.

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Chubby Cheeks is a nursery rhyme about rosy lips, curly hair and lovely blue eyes... But who is this beauty? Sing the song (or read the lyrics below) to find out!

Chubby Cheeks can be used with both boys and girls, but it actually a typical "girlish" nursery rhyme. Why not use it as a mother-daughter-thing? Try to sing "Chubby Cheek" loud next time you are driving car with your daughter? Or sing it and dance next time you are hoime alone? Good luck - and enjoy!

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Chronic lymphocytic leukemia (CLL) is a cancer that affects a type of white blood cell called a "lymphocyte."

Lymphocytes help your body fight infection. They're made in the soft center of your bones, called the marrow. If you have CLL, your body makes an abnormally high number of lymphocytes that aren't working right.

More adults get CLL than any other type of leukemia. It usually grows slowly, so you may not have symptoms for years.

Some people never need treatment, but if you do, it can slow the disease and ease symptoms. People who get medical care live longer today, because doctors are diagnosing CLL earlier.

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